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Campo DC | Valor | Idioma |
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dc.contributor.author | Gaspar-Sobrinho, Fernando Pena | - |
dc.contributor.author | Machado, Adelmir de Souza | - |
dc.contributor.author | Santos, S. B. | - |
dc.contributor.author | Orge, G. | - |
dc.contributor.author | Lessa, Hélio Andrade | - |
dc.contributor.author | Cruz Filho, Álvaro Augusto Souza da | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Gaspar-Sobrinho, Fernando Pena | - |
dc.creator | Machado, Adelmir de Souza | - |
dc.creator | Santos, S. B. | - |
dc.creator | Orge, G. | - |
dc.creator | Lessa, Hélio Andrade | - |
dc.creator | Cruz Filho, Álvaro Augusto Souza da | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2012-10-09T20:42:38Z | - |
dc.date.available | 2012-10-09T20:42:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0100-879X | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6920 | - |
dc.description | p. 1168/1172 | pt_BR |
dc.description.abstract | Human T-cell lymphotropic virus type 1 (HTLV-1) induces an exacerbated type 1 immune response characterized by high spontaneous IFN-γ and TNF-α production. Allergic rhinitis and asthma are associated with the type 2 immune response, with elevated secretion of IL-4 and IL-5. The aim of this study was to characterize the immune response in atopic HTLV-1 carriers. The cytokine profile of atopic HTLV-1 carriers (N = 10; all females) was compared with that of non-atopic HTLV-1 carriers (N = 14; 9 females and 5 males). Mean patient age of atopic and non-atopic groups was 45 ± 8 and 38 ± 11 years, respectively. All atopic HTLV-1 carriers had rhinitis with or without asthma and a skin prick test positive for Dermatophagoides pteronyssinus antigen 1 (Derp-1). There was no difference in cytokine levels between the two groups in unstimulated peripheral blood mononuclear cell cultures. In cultures stimulated with Derp-1, IFN-γ levels tended to be higher (P = 0.06) and IL-5 levels were higher (P = 0.02) in atopic HTLV-1 patients than in non-atopic subjects. In contrast, IL-10 was lower (P = 0.004) in atopic than in non-atopic HTLV-1-infected subjects. This study shows that HTLV-1 infection with an exaggerated type 1 immune response does not prevent atopy. In this case, the exacerbated type 1 and type 2 immune responses were due to a lack of IL-10 production, a cytokine that plays an important role in down-modulating type 1 and type 2 immune responses and in preventing the development of chronic inflammatory diseases. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.source | 10.1590/S0100-879X2010007500138 | pt_BR |
dc.subject | Asthma | pt_BR |
dc.subject | Atopy | pt_BR |
dc.subject | Cytokines | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | Rhinitis | pt_BR |
dc.title | Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection | pt_BR |
dc.title.alternative | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 43 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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Arquivo | Descrição | Tamanho | Formato | |
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Gaspar-Sobrinho, F.P..pdf | 516,08 kB | Adobe PDF | Visualizar/Abrir |
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