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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/6782
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dc.contributor.authorBarreto, George Emílio Sampaio-
dc.contributor.authorOliveira, Elineusa Silva de-
dc.contributor.authorVillar, Flávio Augusto Guerreiro Aragão de-
dc.contributor.authorSantos, Gleide Souza dos-
dc.contributor.authorLima, Rute Maria Ferreira-
dc.contributor.authorCosta, Silvia Lima-
dc.contributor.authorCosta, Maria de Fátima Dias-
dc.contributor.authorEgito, Eryvaldo Sócrates Tabosa-
dc.contributor.authorEl-Bachá, Ramon dos Santos-
dc.creatorBarreto, George Emílio Sampaio-
dc.creatorOliveira, Elineusa Silva de-
dc.creatorVillar, Flávio Augusto Guerreiro Aragão de-
dc.creatorSantos, Gleide Souza dos-
dc.creatorLima, Rute Maria Ferreira-
dc.creatorCosta, Silvia Lima-
dc.creatorCosta, Maria de Fátima Dias-
dc.creatorEgito, Eryvaldo Sócrates Tabosa-
dc.creatorEl-Bachá, Ramon dos Santos-
dc.date.accessioned2012-09-25T17:47:22Z-
dc.date.available2012-09-25T17:47:22Z-
dc.date.issued2007-
dc.identifier.issn1516-8913-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/6782-
dc.descriptionp.839-849pt_BR
dc.description.abstractThe aim of this work was to study the effects of 3MC on the peroxidation of biomolecules in nuclear fractions and nonsynaptic mitochondrial respiration in organelles obtained from rat brains. The cytotoxicity towards rat primary astrocytes in vitro was also tested. 3MC at 1mM oxidized consuming oxygen at a rate of 1.98 ± 0.19 µM.min-1 and formed reactive quinones. At the same concentration, 3MC induced peroxidation of biomolecules in nuclear fractions obtained from rat brain homogenates and inhibited state 2 FADH2-linked respiration in nonsynaptic mitochondria. Furthermore, 3MC oxidized in the culture medium, leading to the formation of quinones. This toluene metabolite was cytotoxic to rat primary astrocytes. The concentration that killed 50% of cells after 72 h was 107 mM. The results of the study indicated a direct relationship between cytotoxicity and 3MC oxidation.pt_BR
dc.language.isoenpt_BR
dc.publisherTecparpt_BR
dc.sourcehttp://dx.doi.org/10.1590/S1516-89132007000500012pt_BR
dc.subjectAstrocytespt_BR
dc.subjectBrainpt_BR
dc.subjectCytotoxicitypt_BR
dc.subject3-methylcatecholpt_BR
dc.subjectPeroxidationpt_BR
dc.subjectRespirationpt_BR
dc.titleInvestigation of toxic factors affecting cells of rat brains exposed to 3-methylcatecholpt_BR
dc.title.alternativeBrazilian Archives of Biology and Technologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.localpubCuritibapt_BR
dc.identifier.numberv. 50, n. 5pt_BR
Aparece nas coleções:Artigo Publicado em Periódico Estrangeiro (ISC)

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