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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/6730
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dc.contributor.authorVan Weyenbergh, Johan-
dc.contributor.authorSantana, Gisélia-
dc.contributor.authorD'Oliveira Junior, Argemiro-
dc.contributor.authorSantos, Anibal F.-
dc.contributor.authorCosta, Carlos Henrique Nery-
dc.contributor.authorCarvalho Filho, Edgar Marcelino de-
dc.contributor.authorBarral, Aldina Maria Prado-
dc.contributor.authorBarral-Netto, Manoel-
dc.creatorVan Weyenbergh, Johan-
dc.creatorSantana, Gisélia-
dc.creatorD'Oliveira Junior, Argemiro-
dc.creatorSantos, Anibal F.-
dc.creatorCosta, Carlos Henrique Nery-
dc.creatorCarvalho Filho, Edgar Marcelino de-
dc.creatorBarral, Aldina Maria Prado-
dc.creatorBarral-Netto, Manoel-
dc.date.accessioned2012-09-17T14:59:13Z-
dc.date.available2012-09-17T14:59:13Z-
dc.date.issued2004-
dc.identifier.issn1471-2334-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/6730-
dc.descriptionp. 1-7pt_BR
dc.description.abstractThe process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite. Blood was collected from 31 patients with either localized cutaneous (LCL), mucosal (ML) or visceral (VL) leishmaniasis, as well as from 25 controls from endemic and non-endemic areas. Anti-Leishmania humoral and cellular immune response were evaluated by quantifying specific plasma IgG, lymphoproliferation and cytokine production, respectively. Plasma levels of Cu and Zn were quantified by atomic absorption spectrophotometry. A significant decrease in plasma Zn was observed in all three patient groups (p < 0.01 for LCL and ML, p < 0.001 for VL), as compared to controls, but only VL (7/10) and ML (1/7) patients displayed overt Zn deficiency. Plasma Cu was increased in LCL and VL (p < 0.001) but not in ML, and was strongly correlated to anti-Leishmania IgG (Spearman r = 0.65, p = 0.0028). Cu/Zn ratios were highest in patients with deficient cellular (VL<<LCL<ML) and exacerbated humoral (VL>LCL>ML) immune response. Ex vivo production of parasite-induced IFN-γ was negatively correlated to plasma Cu levels in LCL (r = -0.57, p = 0.01). In vitro, increased Cu levels inhibited IFN-γ production. 1. Zn deficiency in VL and ML indicate possible therapeutic administration of Zn in these severe forms of leishmaniasis. 2. Plasma Cu positively correlates to humoral immune response across patient groups. 3. Environmentally or genetically determined increases in Cu levels might augment susceptibility to infection with intracellular pathogens, by causing a decrease in IFN-γ production.pt_BR
dc.language.isoenpt_BR
dc.publisherBioMed Centralpt_BR
dc.sourcehttp://dx.doi.org/10.1186/1471-2334-4-50pt_BR
dc.titleZinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro studypt_BR
dc.title.alternativeBMC Infectious Diseasespt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 4, n. 50pt_BR
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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