Campo DC | Valor | Idioma |
dc.contributor.author | Lobato, Cirley | - |
dc.contributor.author | Tavares-Neto, José | - |
dc.contributor.author | Leite, Márcio Rios | - |
dc.contributor.author | Trepo, Christian | - |
dc.contributor.author | Vitvitski, Ludmila | - |
dc.contributor.author | Parvaz, Parviz | - |
dc.contributor.author | Zoulim, Fabien | - |
dc.contributor.author | D'Oliveira Junior, Argemiro | - |
dc.contributor.author | Paraná, Raymundo | - |
dc.creator | Lobato, Cirley | - |
dc.creator | Tavares-Neto, José | - |
dc.creator | Leite, Márcio Rios | - |
dc.creator | Trepo, Christian | - |
dc.creator | Vitvitski, Ludmila | - |
dc.creator | Parvaz, Parviz | - |
dc.creator | Zoulim, Fabien | - |
dc.creator | D'Oliveira Junior, Argemiro | - |
dc.creator | Paraná, Raymundo | - |
dc.date.accessioned | 2012-07-31T20:03:21Z | - |
dc.date.available | 2012-07-31T20:03:21Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6524 | - |
dc.description | RESTRITO | pt_BR |
dc.description.abstract | Background:
Hepatitis B is endemic in the Amazon region.
Methods:
Serological markers for hepatitis B virus (HBV) were determined in 266
household members for hepatitis B surface antigen (HBsAg)-positive women (G1) and 395
household members for HBsAg-negative women (G2), randomly selected in Acre State
Women’s Medical Care Program, in order to evaluate the prevalence of HBV in this
population. Before blood sample collection an epidemiological questionnaire was applied.
Results:
The overall prevalence of HBV carriers (HBsAg) and exposed individuals
(anti-HBc, IgG) was, respectively, 21.1% and 60.5% in G1 and 2.8% and 27.4% in G2
(
P
<
0.0000001). The frequency of HBsAg was higher among siblings from group G1
(75%) compared to the absence of any HBsAg-positive sibling in G2 (
P
<
0.00006). The
HBV markers in other family members was as follows: G1 parents, 27.3% vs 4.5%
(
P
<
0.03), sexual partners, 21.1% vs 2.5% (
P
<
0.04), and offspring, 10.4% vs 1.5%
(
P
<
0.04). A low prevalence of HBsAg and anti-HBc (IgG) was observed for the last
offspring of G2 mothers compared to the high prevalence among children of G1 mothers
(0% vs 18.2%,
P
<
0.01 and 2.3% vs 59.1%,
P
<
0.0000005, respectively), with children
younger than 1 year being the most affected. The frequency of the habit of sharing
toothbrushes and the presence of at least one HBsAg carrier were higher in G1 than in G2
(
P
<
0.0001 and
P
<
0.000002), respectively. Genotypes A, D and G were found to be
predominant by Innolipa test. There were cases that reacted to more than one genotype.
Conclusion:
Intrafamilial transmission of HBV is evident in the present study and is
possibly associated with the presence of more than one HBV carrier in the family and the
shared use of toothbrushes among household contacts. Genotype analysis confirms intrafamilial
transmission. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Hepatology | pt_BR |
dc.source | doi:10.1111/j.1440-1746.2006.04298.x | pt_BR |
dc.title | Intrafamilial prevalence of hepatitis B virus in Western Brazilian Amazon region: Epidemiologic and biomolecular study | pt_BR |
dc.title.alternative | Hepatology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v.21, n.5 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
|