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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/6427
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dc.contributor.authorAthanazio, Daniel Abensur-
dc.contributor.authorSantos, Cleiton S.-
dc.contributor.authorSantos, Andréia C.-
dc.contributor.authorMcBride, Flávia W.C.-
dc.contributor.authorReis, Mitermayer Galvão dos-
dc.creatorAthanazio, Daniel Abensur-
dc.creatorSantos, Cleiton S.-
dc.creatorSantos, Andréia C.-
dc.creatorMcBride, Flávia W.C.-
dc.creatorReis, Mitermayer Galvão dos-
dc.date.accessioned2012-07-13T15:25:08Z-
dc.date.issued2008-
dc.identifier.issn0001-706X-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/6427-
dc.descriptionAcesso restrito: Texto completo. p. 95-98.pt_BR
dc.description.abstractOnly recently, knockout mouse models were applied in studies on the pathogenesis of leptospirosis. Current data suggest an important role of innate immunity receptors and interferon dependant cellular response on protection. It is not clear, however, whether T helper cell polarization influences on outcome of leptospiral infection. We report findings of experimental infection of C57BL/6 (interferon or tumor necrosis factor receptor deficient) and BALB/c (interleukin 4 deficient) mice infected by pathogenic Leptospira interrogans serovar Copenhageni. Specific cytokine gene deficiency had no impact on outcome since all animals survived. TNFR knockout mice, however, exhibited more severe residual renal inflammation during convalescence thus suggesting this cytokine is important in early control of infection, protecting kidneys from relevant pathology.pt_BR
dc.language.isoenpt_BR
dc.sourcehttp://dx.doi.org/10.1016/j.actatropica.2007.09.004pt_BR
dc.subjectLeptospirosispt_BR
dc.subjectLeptospirapt_BR
dc.subjectMicept_BR
dc.subjectKnockoutpt_BR
dc.subjectCytokinespt_BR
dc.subjectAnimal disease modelspt_BR
dc.titleExperimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interroganspt_BR
dc.title.alternativeACTA Tropicapt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 105, n. 2pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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