https://repositorio.ufba.br/handle/ri/6391
Tipo: | Artigo de Periódico |
Título: | Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: Possible mechanisms |
Título(s) alternativo(s): | Pharmacological Research |
Autor(es): | Maia, Juliana Lemos Lima Júnior, Roberto César Pereira Melo, Caroline Mourão David, Juceni Pereira de Lima David, Jorge Mauricio Campos, Adriana Rolim Santos, Flávia Almeida Rao, Vietla Satyanarayana |
Autor(es): | Maia, Juliana Lemos Lima Júnior, Roberto César Pereira Melo, Caroline Mourão David, Juceni Pereira de Lima David, Jorge Mauricio Campos, Adriana Rolim Santos, Flávia Almeida Rao, Vietla Satyanarayana |
Abstract: | The anti-inflammatory pentacyclic triterpene, oleanolic acid (OA) was examined on acute nociception induced by intraplantar injection of capsaicin in mice. OA administered orally to mice at 10, 30 and 100 mg kg−1, significantly attenuated the paw-licking response to capsaicin (1.6 μg/paw) by 53%, 68.5% and 36.6%, respectively. Ruthenium red (3 mg kg−1, s.c.), a non-competitive vanilloid receptor (V1, TRPV1)-antagonist also suppressed the capsaicin nociception by 38.6%. The maximal antinociception produced by 30 mg kg−1 OA was significantly blocked in animals pre-treated with naloxone (2 mg kg−1, i.p.), the opioid antagonist; l-arginine (600 mg kg−1, i.p.), the substrate for nitric oxide synthase; or glibenclamide (2 mg kg−1, i.p.), the KATP-channel blocker, but was unaffected by yohimbine (2 mg kg−1, i.p.), an α2-adrenoceptor antagonist. In open-field and rota-rod tests that detect motor deficits, mice received 30 mg kg−1 OA did not manifest any effect per se, indicating that the observed antinociception is not a consequence of motor abnormality. These data suggest that OA inhibits capsaicin-evoked acute nociception due to mechanisms possibly involving endogenous opioids, nitric oxide, and KATP-channel opening. |
Palavras-chave: | Oleanolic acid Pentacyclic triterpene Capsaicin Antinociceptive activity Endogenous opioids Nitric oxide KATP-channels |
Editora / Evento / Instituição: | Pharmacological Research |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6391 |
Data do documento: | 2006 |
Aparece nas coleções: | Artigo Publicado em Periódico (Química) |
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
DD.pdf | 187,42 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.