Campo DC | Valor | Idioma |
dc.contributor.author | Barcaui, Carlos Baptista | - |
dc.contributor.author | Silva, Ana Maria Goncalves da | - |
dc.contributor.author | Sotto, Miriam N. | - |
dc.contributor.author | Genser, Bernd | - |
dc.creator | Barcaui, Carlos Baptista | - |
dc.creator | Silva, Ana Maria Goncalves da | - |
dc.creator | Sotto, Miriam N. | - |
dc.creator | Genser, Bernd | - |
dc.date.accessioned | 2012-07-10T14:24:59Z | - |
dc.date.available | 2012-07-10T14:24:59Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0303-6987 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6389 | - |
dc.description | RESTRITO | pt_BR |
dc.description.abstract | Background: Diffuse alopecia occurs in almost 7% of HIV-1-infected
patients. Telogen effluvium is the main pathogenic mechanism
involved. Apoptotic keratinocytes in the outer root sheath at bulge level
was described as the most characteristic histopathologic finding of this
kind of hair loss.
Methods: A case–control study was conducted to investigate the
occurrence of apoptosis of follicular stem cells at the bulge in diffuse
alopecia of HIV-1 infection. We applied a double-staining procedure to
transverse scalp sections from 15 HIV-1-infected patients and 12
controls, with the monoclonal antibody anticytokeratin 19 as stem cell
marker and TUNEL technique to identify apoptosis.
Results: Eighty percent of cases and 25% of controls presented at
least one double-stained follicle. The proportion of positive follicles per
section was 48% ( 7%) for cases and 26% ( 13%) for controls.
Conclusion: Our study demonstrated that diffuse alopecia related to
HIV-1 infection represents a hair cycle disturbance and that part of the
follicular stem cell population become apoptotic in a higher proportion
than normal subjects. We found no cytotoxic folliculitis. Owing to its
cell-cycle interaction and caspase-induction capacities, we propose
HIV-1 viral protein R as a possible follicular stem cell apoptosis
inductor. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Journal of Cutaneous Pathology | pt_BR |
dc.source | DOI: 10.1111/j.1600-0560.2006.00517.x | pt_BR |
dc.title | Stem cell apoptosis in HIV-1 alopecia | pt_BR |
dc.title.alternative | Journal of Cutaneous Pathology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Rio de Janeiro | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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