https://repositorio.ufba.br/handle/ri/6373
Tipo: | Artigo de Periódico |
Título: | Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors |
Título(s) alternativo(s): | Journal of Molecular Histology |
Autor(es): | Santos, Jean Nunes dos Oliveira, Gabriel Queiroz Vasconcelos Gurgel, Clarissa Araújo Silva Souza, Renata Oliveira de Sales, Caroline Brandi Schlaepfer Valença Neto, Alberto de Aguiar Pires Ramos, Eduardo Antônio Gonçalves |
Autor(es): | Santos, Jean Nunes dos Oliveira, Gabriel Queiroz Vasconcelos Gurgel, Clarissa Araújo Silva Souza, Renata Oliveira de Sales, Caroline Brandi Schlaepfer Valença Neto, Alberto de Aguiar Pires Ramos, Eduardo Antônio Gonçalves |
Abstract: | Keratocystic odontogenic tumor (KOT) is a benign cystic tumor that affects the jaw bones and may be associated with the nevoid basal cell carcinoma syndrome (NBCCS). Twenty-five cases diagnosed as KOT, including primary and recurrent tumors and those associated with NBCCS, were submitted to immunohistochemical study for analysis of cytokeratins (CKs) 7, 8, 10, 13, 14, 18 and 19. The results showed CK13 immunostained on the intermediate layers and upper cells. CK14 was expressed in all epithelial layers and in those areas where inflammation and subepithelial splits were present; this protein was preserved within the basal cells. CK 18 was expressed mainly in the basal layer, whereas CK19 was expressed mainly on the intermediate and superficial layers. The remaining CKs tested were not immuoreactive. The status of maturation of cytokeratin seems to be altered on KOTs, and this is not distinct when different tumors are compared. |
Palavras-chave: | Cytokeratin Odontogenic Keratocysts Odontogenic Neoplasms Immunohistochemistry |
Editora / Evento / Instituição: | Springer Verlag |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6373 |
Data do documento: | 2009 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Odontologia) |
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