https://repositorio.ufba.br/handle/ri/6272
Tipo: | Artigo de Periódico |
Título: | WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis |
Título(s) alternativo(s): | Journal of Oral Pathology and Medicine |
Autor(es): | Xavier, Flávia Caló de Aquino Rodini, Camila Oliveira Ramalho, Luciana Maria Pedreira Mantesso, Andrea Nunes, Fabio Daumas |
Autor(es): | Xavier, Flávia Caló de Aquino Rodini, Camila Oliveira Ramalho, Luciana Maria Pedreira Mantesso, Andrea Nunes, Fabio Daumas |
Abstract: | Oncogenic Wnt/b-catenin signaling occurs in numerous types of cancers, but little is known about the role of the Wnt protein family member, WNT- 5A, in lip carcinogenesis. The aim of this study was to investigate WNT-5A, b-catenin, and matrix metalloproteinase (MMP)-3 protein expression in actinic cheilitis (AC), and lip squamous cell carcinoma (LSCC). METHODS: Twenty-one cases of AC, and fifty-one cases of LSCC were analyzed, with normal lip mucosa used as a control. Qualitative and semi-quantitative analyses of WNT-5A, b-catenin, and MMP-3 immunostaining pattern and cellular distribution were performed. RESULTS: WNT-5A was observed in more than 50% of the cells, scattered in all layers of AC, in contrast to the absence of immunostaining in normal lip mucosa. AC presented a higher level of WNT-5A expression than LSCC (P = 0.0289, Fisher test), while MMP-3 immunoexpression was statistically more significant in LSCC than in AC (P = 0.0285, Fisher test). Immunolabeling of b-catenin protein was differentially distributed between samples; the majority of AC cases (61.90%) demonstrated a membranous-cytoplasmic pattern, while a considerable number of LSCC cases (29.41%) revealed a cytoplasmic pattern, instead of the usual membranous pattern. CONCLUSIONS: The present results suggest that WNT-5A may be an important marker during initial events of AC malignant transformation, in which noncanonical and canonical Wnt/b-catenin signaling pathways could be involved. Additionally, WNT-5A might recruit other events in LSCC, such as MMP-3 protein synthesis, as its presence is increased in established malignant processes without b-catenin dependency. |
Palavras-chave: | actinic cheilitis MMP-3 squamous cell carcinoma WNT-5A protein b-catenin |
Editora / Evento / Instituição: | John Wiley and Sons |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6272 |
Data do documento: | 2009 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Odontologia) |
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
(94)j.1600-0714.2009.00756.x.pdf Restricted Access | 710,45 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.