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dc.contributor.authorGurgel, Clarissa Araújo Silva-
dc.contributor.authorRamos, Eduardo Antônio Gonçalves-
dc.contributor.authorAzevedo, Roberto Almeida de-
dc.contributor.authorSarmento, Viviane Almeida-
dc.contributor.authorCarvalho, Ana Maria da Silva-
dc.contributor.authorSantos, Jean Nunes dos-
dc.creatorGurgel, Clarissa Araújo Silva-
dc.creatorRamos, Eduardo Antônio Gonçalves-
dc.creatorAzevedo, Roberto Almeida de-
dc.creatorSarmento, Viviane Almeida-
dc.creatorCarvalho, Ana Maria da Silva-
dc.creatorSantos, Jean Nunes dos-
dc.descriptionAcesso restrito: Texto completo. p. 311-316.pt_BR
dc.description.abstractAim To investigate the immunohistochemical expression of Ki-67, p53 and p63 in Keratocyst Odontogenic Tumours (KOTs) in order to contribute to the biological profile of this tumor. Methods Immunohistochemical technique was performed using the EnVisionTM System in 37 cases of KOTs. Results Ki-67- and p53-immunostained cells were mainly located in the suprabasal layers. p63-positive cells were found throughout the lining cystic epithelium. No difference in the immunostaining for these proteins was observed between primary and recurrent KOTs (Ki-67: P = 0.5591; p53: P = 0.9847; p63:P = 0.9127), or between KOTs associated with Nevoid Basal Cell Carcinoma Syndrome (NBCCS) and sporadic KOTs (Ki-67: P = 0.7013; p53: P = 0.3197; p63: P = 0.2427). Conclusions It is possible that biological behavior of KOTs may be related to suprabasal proliferative compartment in the cystic epithelium as observed by high levels of Ki-67, p53 and p63. In addition, p63 immunostaining may represent immaturity of keratinocytes in KOTs, and suggests that this protein may participate in the regulation of epithelial cell differentiation. Taken together, these data may favor tumorigenesis on KOTs.pt_BR
dc.subjectOdontogenic cystspt_BR
dc.subjectKeratocyst odontogenic tumourpt_BR
dc.subjectCell proliferationpt_BR
dc.titleExpression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical studypt_BR
dc.title.alternativeJournal of Molecular Histologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 39, n. 3pt_BR
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Odontologia)

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