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dc.contributor.authorSantos, Washington Luis Conrado dos-
dc.contributor.authorJesus, E. E.-
dc.contributor.authorSilva, M. Paranhos-
dc.contributor.authorPereira, A. M.-
dc.contributor.authorSantos, J. C.-
dc.contributor.authorBaleeiro, C. O.-
dc.contributor.authorNascimento, E. G.-
dc.contributor.authorMoreira, E. D.-
dc.contributor.authorOliveira, G. G. S.-
dc.contributor.authorCarvalho, Lain Carlos Pontes de-
dc.creatorSantos, Washington Luis Conrado dos-
dc.creatorJesus, E. E.-
dc.creatorSilva, M. Paranhos-
dc.creatorPereira, A. M.-
dc.creatorSantos, J. C.-
dc.creatorBaleeiro, C. O.-
dc.creatorNascimento, E. G.-
dc.creatorMoreira, E. D.-
dc.creatorOliveira, G. G. S.-
dc.creatorCarvalho, Lain Carlos Pontes de-
dc.descriptionAcesso restrito: Texto completo. p. 251-259pt_BR
dc.description.abstractAssociations among parameters commonly used as markers of infection by Leishmania sp., or of susceptibility to visceral leishmaniasis, were investigated in 325 stray dogs from an area where this disease is endemic. Evidence of infection (presence of Leishmania in splenic cultures, positive leishmanin skin test (LST) or detection of anti-Leishmania antibody activity in the serum) was found in 57% of the animals. Both evidence of weight loss (x2-test, P = 0.0005) and presence of specific antibody activity in the serum (x2-test, P < 0.0001) were directly associated with positive splenic culture. The frequencies of animals with positive splenic culture were directly correlated with the intensities of antibody activity in the serum as measured by ELISA (relative risk of 3.4 for animals with moderate antibody levels and relative risk of 8.43 for animals with high-antibody levels). A negative association was observed between positive leishmanin skin test results and emaciation (x2, P = 0.0089). Furthermore, animals with positive splenic cultures and negative leishmanin skin test results had higher levels of total serum IgG (Kruskal–Wallis test, P = 0.001) and IgG2 (Kruskal–Wallis test, P = 0.05) than animals with negative splenic cultures, and were more emaciated than animals with negative LST results and positive splenic cultures. The data presented herein suggest that associating these common parameters may improve their performance in predicting susceptibility to canine visceral leishmaniasis.pt_BR
dc.subjectLeishmanin skin testpt_BR
dc.subjectCanine visceral leishmaniasispt_BR
dc.subjectLeishmania chagasipt_BR
dc.subjectLeishmania infantumpt_BR
dc.subjectImmunoglobulin isotypespt_BR
dc.titleAssociations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: emaciation, spleen parasitism, specific antibodies and leishmanin skin test reactionpt_BR
dc.title.alternativeVeterinary Immunology and Immunopathologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 123, n. 3-4pt_BR
Appears in Collections:Artigo Publicado em Periódico (ICS)

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