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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/6003
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dc.contributor.authorSantos, Djanilson Barbosa-
dc.contributor.authorClavenna, Antonio-
dc.contributor.authorBonati, Maurizio-
dc.contributor.authorCoelho, Helena Lutescia Luna-
dc.creatorSantos, Djanilson Barbosa-
dc.creatorClavenna, Antonio-
dc.creatorBonati, Maurizio-
dc.creatorCoelho, Helena Lutescia Luna-
dc.date.accessioned2012-05-30T19:51:52Z-
dc.date.issued2008-
dc.identifier.issn0031-6970-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/6003-
dc.descriptionAcesso restrito: Texto completo. p. 1111-1118.pt_BR
dc.description.abstractObjectives To investigate the use of drugs, the extent and pattern of unlicensed and off-label use, and the potential relationship between off-label drug use and adverse drug reactions in northeastern Brazil. Methods A follow-up study of drug utilization in a general ward of a pediatric reference hospital, involving patients hospitalized for more than 24 h. Prescriptions and medical records were reviewed daily from August to December 2001. Drug licensing status of all prescriptions given to these patients was determined. Results A total of 272 patients were admitted during the study, 265 (97.4%) of whom received one or more drugs. The median number of drugs/patient was 6 (1–18), and the most frequent diagnosis was pneumonia (29.4% of patients). The therapeutic class most prescribed was antiinfectives for systemic use (68.8% of all children). In all, 82.6% of children received at least one unlicensed or offlabel drug, and 17% received both an unlicensed and an off-label drug. Dose/frequency was the most common form of off-label drug use. Off-label drug use was significantly associated with adverse drug reactions (relative risk 2.44; 95% CI 2.12, 2.89). Conclusions Although off-label drug use is a complex issue and is not synonymous with inappropriate drug use, a high rate of unlicensed/off-label drug use was found and was also associated with an increased risk of adverse drug reactions. More efforts are needed to increase rational drug use in children.pt_BR
dc.language.isoenpt_BR
dc.sourcehttp://www.springerlink.com/content/yxv135w602750g63/fulltext.pdfpt_BR
dc.subjectPharmacoepidemiologypt_BR
dc.subjectDrug utilizationpt_BR
dc.subjectHospitalized childrenpt_BR
dc.subjectOff-labelpt_BR
dc.subjectUnlicensedpt_BR
dc.subjectPediatricspt_BR
dc.titleOff-label and unlicensed drug utilization in hospitalized children in Fortaleza, Brazilpt_BR
dc.title.alternativeEUROPEAN JOURNAL OF CLINICAL PHARMACOLOGYpt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 64, n. 11pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (FAR)

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