https://repositorio.ufba.br/handle/ri/5650
Tipo: | Artigo de Periódico |
Título: | Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
Título(s) alternativo(s): | Lipids in Health and Disease |
Autor(es): | Seixas, Magda Oliveira Rocha, Larissa C. Carvalho, Mauricio B. Menezes, Joelma Figueiredo Lyra, Isa Menezes Nascimento, Valma M. L. Couto, Ricardo David Atta, Ajax Mercês Reis, Mitermayer G. Goncalves, Marilda S. |
Autor(es): | Seixas, Magda Oliveira Rocha, Larissa C. Carvalho, Mauricio B. Menezes, Joelma Figueiredo Lyra, Isa Menezes Nascimento, Valma M. L. Couto, Ricardo David Atta, Ajax Mercês Reis, Mitermayer G. Goncalves, Marilda S. |
Abstract: | Background: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up.We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steadystate children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, antiaggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. Methods: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. Results: Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005), bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001), aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol (P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of cholelithiasis. Conclusions: We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5650 |
Data do documento: | 2010 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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C__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf | 217,92 kB | Adobe PDF | Visualizar/Abrir |
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