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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5581
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dc.contributor.authorLyra, Priscila Pinheiro Ribeiro-
dc.contributor.authorDiniz, E. M. A.-
dc.contributor.authorAbe Sandes, Kiyoko-
dc.contributor.authorAngelo, Ana Luiza Dias-
dc.contributor.authorMachado, Taisa Manuela Bonfim-
dc.contributor.authorCardeal, Mauricio-
dc.creatorLyra, Priscila Pinheiro Ribeiro-
dc.creatorDiniz, E. M. A.-
dc.creatorAbe Sandes, Kiyoko-
dc.creatorAngelo, Ana Luiza Dias-
dc.creatorMachado, Taisa Manuela Bonfim-
dc.creatorCardeal, Mauricio-
dc.date.accessioned2012-03-30T13:33:35Z-
dc.date.available2012-03-30T13:33:35Z-
dc.date.issued2011-
dc.identifier.issn0100-879X-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/5581-
dc.descriptionp. 66-72pt_BR
dc.description.abstractThe etiology of respiratory distress syndrome (RDS) is multifactorial and multigenic. Studies have suggested that polymorphisms and mutations in the surfactant protein B (SP-B) gene are associated with the pathogenesis of RDS. The objectives of this study were to determine and compare the frequencies of SP-B gene polymorphisms in preterm babies with and without RDS. We studied 151 neonates: 79 preterm babies without RDS and 72 preterm newborns with RDS. The following four SP-B gene polymorphisms were analyzed: A/C at -18, C/T at 1580, A/G at 9306, and G/C at nucleotide 8714. The polymorphisms were detected by PCR amplification of genomic DNA and genotyping. The genotypes were determined using PCR-based converted restriction fragment length polymorphisms. The control group consisted of 42 (53%) girls and 37 (47%) boys. Weight ranged from 1170 to 3260 g and mean gestational age (GA) was 33.9 weeks (range: 29 to 35 weeks and 6 days). The RDS group consisted of 31 (43%) girls and 41 (57%) boys. Weight ranged from 614 to 2410 g and mean GA was 32 weeks (range: 26 to 35 weeks). The logistic regression model showed that GA was the variable that most contributed to the occurrence of RDS. The AG genotype of the A/G polymorphism at position 9306 of the SP-B gene was a protective factor in this population (OR = 0.1681; 95%CI = 0.0426-0.6629). We did not detect differences in the frequencies of the other polymorphisms between the two groups of newborns.pt_BR
dc.language.isoenpt_BR
dc.sourcehttp://dx.doi.org/10.1590/S0100-879X2010007500147pt_BR
dc.subjectNewborn respiratory distress syndromept_BR
dc.subjectGenetic polymorphismpt_BR
dc.subjectSurfactant protein Bpt_BR
dc.titleSurfactant protein B gene polymorphism in preterm babies with respiratory distress syndromept_BR
dc.title.alternativeBrazilian Journal of Medical and Biological Researchpt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.localpubRibeirão Pretopt_BR
dc.identifier.numberv. 44, n. 1.pt_BR
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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