https://repositorio.ufba.br/handle/ri/5487
Tipo: | Artigo de Periódico |
Título: | Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin |
Título(s) alternativo(s): | JOURNAL OF NATURAL PRODUCTS |
Autor(es): | Lima, Flávia Oliveira de Nonato, Fabiana Regina Couto, Ricardo David Barbosa Filho, José Maria Nunes, Xirley Pereira Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
Autor(es): | Lima, Flávia Oliveira de Nonato, Fabiana Regina Couto, Ricardo David Barbosa Filho, José Maria Nunes, Xirley Pereira Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
Abstract: | 7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice with 1 produced a long-lasting antinociceptive effect against complete Freund’s adjuvant (CFA)-induced hyperalgesia. The subchronic administration of 1 inhibited CFA-induced hyperalgesia and paw edema, while it did not cause any apparent toxicity. Another set of experiments showed that 1 inhibited carrageenan-induced mechanical hyperalgesia, but not mechanical hyperalgesia induced by prostaglandin E2 (PGE2), suggesting that it acts upstream of PGE2. Treatment with 1 was able to prevent the plantar tissue neutrophil influx induced by local inflammatory stimuli. In addition, 1 exhibited inhibitory effects on the release of hyperalgesic cytokines (TNF-R and IL-1β) and the production of PGE2, a directly acting hyperalgesic mediator. The present results suggest that the antinociceptive effect of 1 is correlated with the inhibition of neutrophil migration, cytokine release, and PGE2 production and are supportive of the further investigation of the therapeutic potential of 1 to control inflammatory pain. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5487 |
Data do documento: | 2011 |
Aparece nas coleções: | Artigo Publicado em Periódico (Química) |
Arquivo | Descrição | Tamanho | Formato | |
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C__Documents and Settings_rep...t.default_Cache_0_D1_CC9D1d01.pdf | 268,64 kB | Adobe PDF | Visualizar/Abrir |
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