Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/5467
metadata.dc.type: Artigo Publicado em Periódico
Title: Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains
Other Titles: PLoS ONE
Authors: Ruiz, Jerônimo Conceição
Ferreira, Vívian D'Afonseca da Silva
Silva, Artur Luiz da Costa da
Ali, Amjad
Pinto, Anne Cybelle
Santos, Anderson Rodrigues dos
Rocha, Aryane Aparecida Magalhães Cassiano
Lopes, Débora de Oliveira
Dorella, Fernanda Alves
Pacheco, Luis Gustavo Carvalho
Costa, Marcilia Pinheiro da
Turk, Meritxell Zurita
Seyffert, Núbia
Moraes, Pablo Matias Ribeiro de Oliveira
Soares, Siomar de Castro
Almeida, Sintia Silva de
Castro, Thiago Luiz de Paula
Abreu, Vinicius Augusto Carvalho de
Trost, Eva
Baumbach, Jan
Tauch, Andreas
Schneider, Maria Paula Cruz
McCulloch, John Anthony
Cerdeira, Louise Teixeira
Ramos, Rommel Thiago Juca
Zerlotini, Adhemar
Dominitini, Anderson
Resende, Daniela de Melo
Coser, Elisângela Monteiro
Oliveira, Luciana Márcia de
Pedrosa, André Luiz
Ueira-Vieira, Carlos
Guimarães, Claudia Teixeira
Bartholomeu, Daniela C.
Oliveira, Magalhães de
Santos, Fabrício R.
Rabelo, Élida Mara
Lobo, Francisco Pereira
Franco, Gloria Regina
Costa, Ana Flávia
Castro, Ieso M.
Dias, Sílvia Regina Costa
Ferro, Jesus Aparecido
Ortega, José Miguel
Paiva, Luciano Vilela
Goulart Filho, Luiz Ricardo
Almeida, Juliana Franco
Ferro, Maria Inês Tiraboschi
Carneiro, Newton Portilho
Falcão, Paula Regina Kuser
Grynberg, Priscila
Teixeira, Santuza Maria Ribeiro
Brommonschenkel, Sérgio
Oliveira, Sérgio Costa
Nascimento, Roberto José Meyer
Moore, Robert J.
Miyoshi, Anderson
Oliveira, Guilherme C.
Azevedo, Vasco Ariston de Carvalho
metadata.dc.creator: Ruiz, Jerônimo Conceição
Ferreira, Vívian D'Afonseca da Silva
Silva, Artur Luiz da Costa da
Ali, Amjad
Pinto, Anne Cybelle
Santos, Anderson Rodrigues dos
Rocha, Aryane Aparecida Magalhães Cassiano
Lopes, Débora de Oliveira
Dorella, Fernanda Alves
Pacheco, Luis Gustavo Carvalho
Costa, Marcilia Pinheiro da
Turk, Meritxell Zurita
Seyffert, Núbia
Moraes, Pablo Matias Ribeiro de Oliveira
Soares, Siomar de Castro
Almeida, Sintia Silva de
Castro, Thiago Luiz de Paula
Abreu, Vinicius Augusto Carvalho de
Trost, Eva
Baumbach, Jan
Tauch, Andreas
Schneider, Maria Paula Cruz
McCulloch, John Anthony
Cerdeira, Louise Teixeira
Ramos, Rommel Thiago Juca
Zerlotini, Adhemar
Dominitini, Anderson
Resende, Daniela de Melo
Coser, Elisângela Monteiro
Oliveira, Luciana Márcia de
Pedrosa, André Luiz
Ueira-Vieira, Carlos
Guimarães, Claudia Teixeira
Bartholomeu, Daniela C.
Oliveira, Magalhães de
Santos, Fabrício R.
Rabelo, Élida Mara
Lobo, Francisco Pereira
Franco, Gloria Regina
Costa, Ana Flávia
Castro, Ieso M.
Dias, Sílvia Regina Costa
Ferro, Jesus Aparecido
Ortega, José Miguel
Paiva, Luciano Vilela
Goulart Filho, Luiz Ricardo
Almeida, Juliana Franco
Ferro, Maria Inês Tiraboschi
Carneiro, Newton Portilho
Falcão, Paula Regina Kuser
Grynberg, Priscila
Teixeira, Santuza Maria Ribeiro
Brommonschenkel, Sérgio
Oliveira, Sérgio Costa
Nascimento, Roberto José Meyer
Moore, Robert J.
Miyoshi, Anderson
Oliveira, Guilherme C.
Azevedo, Vasco Ariston de Carvalho
Abstract: Background: Corynebacterium pseudotuberculosis, a Gram-positive, facultative intracellular pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL mainly affects small ruminants, such as goats and sheep; it also causes infections in humans, though rarely. This species is distributed worldwide, but it has the most serious economic impact in Oceania, Africa and South America. Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity. Methodology and Findings: We characterized two C. pseudotuberculosis genomes (Cp1002, isolated from goats; and CpC231, isolated from sheep). Analysis of the predicted genomes showed high similarity in genomic architecture, gene content and genetic order. When C. pseudotuberculosis was compared with other Corynebacterium species, it became evident that this pathogenic species has lost numerous genes, resulting in one of the smallest genomes in the genus. Other differences that could be part of the adaptation to pathogenicity include a lower GC content, of about 52%, and a reduced gene repertoire. The C. pseudotuberculosis genome also includes seven putative pathogenicity islands, which contain several classical virulence factors, including genes for fimbrial subunits, adhesion factors, iron uptake and secreted toxins. Additionally, all of the virulence factors in the islands have characteristics that indicate horizontal transfer. Conclusions: These particular genome characteristics of C. pseudotuberculosis, as well as its acquired virulence factors in pathogenicity islands, provide evidence of its lifestyle and of the pathogenicity pathways used by this pathogen in the infection process. All genomes cited in this study are available in the NCBI Genbank database (http://www.ncbi.nlm.nih.gov/ genbank/) under accession numbers CP001809 and CP001829.
URI: http://www.repositorio.ufba.br/ri/handle/ri/5467
Issue Date: 2011
Appears in Collections:Artigo Publicado em Periódico (Biologia)

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