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metadata.dc.type: Artigo de Periódico
Title: Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil
Other Titles: Memórias do Instituto Oswaldo Cruz
Authors: Santos, Washington Luis Conrado dos
Sweet, Gloria Maria Maranhão
Oliveira, Marilia Bahiense
Rocha, Paulo Novis
metadata.dc.creator: Santos, Washington Luis Conrado dos
Sweet, Gloria Maria Maranhão
Oliveira, Marilia Bahiense
Rocha, Paulo Novis
Abstract: Distinct patterns of glomerular lesions, including membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis, are associated with infection by Schistosoma mansoni or Schistosoma japonicum. Evidence suggests that immune complex deposition is the main mechanism underlying the different forms of schistosomal glomerulonephritis and that immune complex deposition may be intensified by portal hypertension. The relationship between focal segmental glomerulosclerosis and schistosomiasis remains poorly understood. A clinicopathologic classification of schistosomal glomerulopathies was proposed in 1992 by the African Association of Nephrology. In Brazil, mass treatment with oral medications has led to a decrease in the occurrence of schistosomal glomerulopathy. In a survey of renal biopsies performed in Salvador, Brazil, from 2003-2009, only 24 (4%) patients were identified as positive for S. mansoni infection. Among these patients, only one had the hepatosplenic form of the disease. Focal segmental glomerulosclerosis was found in seven patients and membranoproliferative glomerulonephritis was found in four patients. Although retrospective studies on the prevalence of renal diseases based on kidney biopsies may be influenced by many patient selection biases, a change in the distribution of glomerulopathies associated with nephrotic syndrome was observed along with a decline in the occurrence of severe forms of schistosomiasis.
Keywords: Schistosoma japonicum
Schistosoma mansoni
mesangiocapillary glomerulonephritis
kidney diseases
focal segmental glomerulosclerosis
Issue Date: 2011
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

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