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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5453
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dc.contributor.authorBafica, Aline Michelle Barbosa-
dc.contributor.authorCardoso, Luciana Santos-
dc.contributor.authorOliveira, Sérgio Costa-
dc.contributor.authorLoukas, Alex-
dc.contributor.authorVarela, Giuseppe Tittoni-
dc.contributor.authorOliveira, Ricardo Riccio-
dc.contributor.authorBacellar, Maria Olívia Amado Ramos-
dc.contributor.authorCarvalho Filho, Edgar Marcelino de-
dc.contributor.authorAraujo, Maria Ilma Andrade Santos-
dc.creatorBafica, Aline Michelle Barbosa-
dc.creatorCardoso, Luciana Santos-
dc.creatorOliveira, Sérgio Costa-
dc.creatorLoukas, Alex-
dc.creatorVarela, Giuseppe Tittoni-
dc.creatorOliveira, Ricardo Riccio-
dc.creatorBacellar, Maria Olívia Amado Ramos-
dc.creatorCarvalho Filho, Edgar Marcelino de-
dc.creatorAraujo, Maria Ilma Andrade Santos-
dc.date.accessioned2012-02-25T16:34:45Z-
dc.date.available2012-02-25T16:34:45Z-
dc.date.issued2011-
dc.identifier.issn1678-8060-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/5453-
dc.descriptionp. 856-863.pt_BR
dc.description.abstractSchistosoma mansoni infection or associated products are able to down-modulate the type 1 CD4+ T cell inflammatory response characteristic of autoimmune diseases. In this study, we evaluated how S. mansoni antigens altered the immune response that was induced by the soluble Leishmania antigen (SLA) from cutaneous leishmaniasis (CL) patients. Cytokines were measured from the supernatants of peripheral blood mononuclear cell cultures stimulated with SLA. This was performed using the sandwich enzyme linked immunosorbent assay technique in the presence or absence of S. mansoni recombinant antigens Sm29, SmTSP-2 and PIII. The addition of S. mansoni antigens to the cultures resulted in the reduction of interferon gamma (IFN-γ) levels in 37-50% of patients. Although to a lesser extent, the antigens were also able to decrease the production of tumour necrosis factor-alpha (TNF-α). We compared patients that either had or did not have reduction in IFN-γ and TNF-α production in cultures stimulated with SLA in the presence of S. mansoni antigens. We found that there was no significant difference in the levels of interleukin (IL)-10 and IL-5 in response to S. mansoni antigens between the groups. The antigens used in this study down-modulated the in vitro proinflammatory response induced by SLA in a group of CL patients through a currently undefined mechanism.pt_BR
dc.language.isoenpt_BR
dc.subjectcutaneous leishmaniasispt_BR
dc.subjectS. mansoni antigenspt_BR
dc.subjectSm29pt_BR
dc.subjectSmTSP-2pt_BR
dc.subjectPIIIpt_BR
dc.titleSchistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasispt_BR
dc.title.alternativeMemórias do Instituto Oswaldo Cruzpt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.number106(7)pt_BR
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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