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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5422
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dc.contributor.authorLyra, Isa Menezes-
dc.contributor.authorMoura Neto, José Pereira de-
dc.contributor.authorReis, Mitermayer Galvão dos-
dc.contributor.authorBarbosa, Cynara Gomes-
dc.contributor.authorGonçalves, Marilda de Souza-
dc.contributor.authorCerqueira, Bruno Antonio Veloso-
dc.contributor.authorCouto, Fábio David-
dc.contributor.authorCajado, C.-
dc.contributor.authorSantos, Wendell Vilas Boas-
dc.contributor.authorDorea, M. J.-
dc.creatorLyra, Isa Menezes-
dc.creatorMoura Neto, José Pereira de-
dc.creatorReis, Mitermayer Galvão dos-
dc.creatorBarbosa, Cynara Gomes-
dc.creatorGonçalves, Marilda de Souza-
dc.creatorCerqueira, Bruno Antonio Veloso-
dc.creatorCouto, Fábio David-
dc.creatorCajado, C.-
dc.creatorSantos, Wendell Vilas Boas-
dc.creatorDorea, M. J.-
dc.date.accessioned2012-02-23T17:08:28Z-
dc.date.issued2011-
dc.identifier.issn1096-0023-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/5422-
dc.descriptiontexto completo: acesso restrito. p. 312–317.pt_BR
dc.description.abstractSickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) ÿ308G>A and Interleukin 8 (IL-8) ÿ251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-state SCA. In total, 210 SCA patients aged 2–21 years and 200 healthy controls were studied. Gene polymorphisms, betaS-globin haplotypes and a 3.7-kb deletion in alpha2-thalassemia (a2-thal3.7 kb) were investigated by PCR/RFLP analysis, and cytokine levels were determined by ELISA. Splenomegaly (p = .032) was more prevalent among children younger than 5 years of age. The A allele of the TNF-alpha ÿ308G>A gene polymorphism and the presence of a2-thal3.7 kb were associated with an increase risk of splenic sequestration events (p = .001; p = .046), while the T allele of the IL-8 ÿ251A>T gene polymor-phism was considered to be a protective factor for splenomegaly events (p = .032). Moreover, the A allele of the TNF-alpha ÿ308G>A gene polymorphism was associated with high TNF-alpha levels (p = .021), and the hemoglobin F and hemoglobin S haplotypes were correlated with serum levels of IL-8. The logistic regression analysis showed significant effects of the TNF-alpha and IL-8 gene polymorphisms, betaS-globin gene haplotypes and a2-thal3.7 kb on the occurrence of splenic sequestration events. Our study empha-sizes that the identification of new genetic and immunological biomarkers and their associations with classical markers is an important strategy to elucidate the underlying causes of different SCA phenotypes and their effects on patient outcome.pt_BR
dc.language.isoenpt_BR
dc.sourcedoi:10.1016/j.cyto.2011.07.002pt_BR
dc.subjectTNF-alphapt_BR
dc.subjectIL-8pt_BR
dc.subjectSickle cell anemiapt_BR
dc.subjectbetaS-globin Gene haplotypespt_BR
dc.subjectalpha2-Thalassemiapt_BR
dc.titleTNF-alpha and IL-8: Serum levels and gene polymorphisms (ÿ308G>A and ÿ251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemiapt_BR
dc.title.alternativeCytokinept_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 56.pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (FAR)

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