https://repositorio.ufba.br/handle/ri/5369
metadata.dc.type: | Artigo de Periódico |
Title: | Antinociceptive Properties of Bergenin |
Other Titles: | Journal of Natural Products |
Authors: | Oliveira, Cristiane Metzker de Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
metadata.dc.creator: | Oliveira, Cristiane Metzker de Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
Abstract: | Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with 1 (12.5 100 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with 1 (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, 1 (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-α and IL-1β) induced by complete Freund’s adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by 1 (100 mg/kg, ip). Treatment with 1 produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with 1 did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1β and TNF-α production, and suggest its potential for the control of inflammatory pain. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5369 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (Química) |
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C__Documents and Settings_rep...9.default_Cache_6_AE_72E54d01.pdf | 285,6 kB | Adobe PDF | View/Open |
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