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Campo DC | Valor | Idioma |
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dc.contributor.author | Lima, Alessandra Estrela da Silva | - |
dc.contributor.author | Araújo, Márcio Sobreira Silva | - |
dc.contributor.author | Costa Neto, João Moreira da | - |
dc.contributor.author | Carvalho, Andréa Teixeira | - |
dc.contributor.author | Melo, Stella Maria Barrouin | - |
dc.contributor.author | Cardoso, Sergio V. | - |
dc.contributor.author | Martins Filho, Olindo Assis | - |
dc.contributor.author | Serakides, Rogéria | - |
dc.contributor.author | Cassali, Geovanni Dantas | - |
dc.creator | Lima, Alessandra Estrela da Silva | - |
dc.creator | Araújo, Márcio Sobreira Silva | - |
dc.creator | Costa Neto, João Moreira da | - |
dc.creator | Carvalho, Andréa Teixeira | - |
dc.creator | Melo, Stella Maria Barrouin | - |
dc.creator | Cardoso, Sergio V. | - |
dc.creator | Martins Filho, Olindo Assis | - |
dc.creator | Serakides, Rogéria | - |
dc.creator | Cassali, Geovanni Dantas | - |
dc.date.accessioned | 2012-02-08T13:22:32Z | - |
dc.date.available | 2012-02-08T13:22:32Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/5327 | - |
dc.description.abstract | Background: The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant cells is still controversial, and the cell subsets and the mechanisms involved are poorly investigated. The goal of this study was to characterize the clinical-pathological status and the immunophenotyping profile of tumor infiltrating lymphocytes and their association with the animal survival rates in canine mammary carcinomas. Methods: Fifty-one animals with mammary carcinomas, classified as carcinomas in mixed tumors-MC-BMT = 31 and carcinomas-MC = 20 were submitted to systematic clinical-pathological analysis (tumor size; presence of lymph node and pulmonary metastasis; clinical stage; histological grade; inflammatory distribution and intensity as well as the lymphocytic infiltrate intensity) and survival rates. Twenty-four animals (MC-BMT = 16 and MC = 8) were elected to the immunophenotypic study performed by flow cytometry. Results: Data analysis demonstrated that clinical stage II-IV and histological grade was I more frequent in MC-BMT as compared to MC. Univariate analysis demonstrated that the intensity of inflammation (moderate/intense) and the proportion of CD4+ (≥ 66.7%) or CD8+ T-cells (<33.3%) were not associated with worse survival rate. Multivariate analysis demonstrated that only lymphocytic infiltrate intensity ≥ 600 (P = 0.02) remained as independent prognostic factor. Despite the clinical manifestation, the lymphocytes represented the predominant cell type in the tumor infiltrate. The percentage of T-cells was higher in animals with MC-BMT without metastasis, while the percentage of Blymphocytes was greater in animals with metastasized MC-BMT (P < 0.05). The relative percentage of CD4+ T-cells was significantly greater in metastasized tumors (both MC-BMT and MC), (P < 0.05) while the proportion of CD8+ T-cells was higher in MC-BMT without metastasis. Consequently, the CD4+/CD8+ ratio was significantly increased in both groups with metastasis. Regardless of the tumor type, the animals with high proportions of CD4+ and low CD8+ T-cells had decreased survival rates. Conclusion: The intensity of lymphocytic infiltrate and probably the relative abundance of the CD4+ and CD8+ Tlymphocytes may represent important survival prognostic biomarkers for canine mammary carcinomas. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | 10.1186/1471-2407-10-256 | pt_BR |
dc.title | Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates | pt_BR |
dc.title.alternative | BMC Cancer | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (EMV) |
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1471-2407-10-256.pdf | 1,26 MB | Adobe PDF | Visualizar/Abrir |
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