https://repositorio.ufba.br/handle/ri/5317
Campo DC | Valor | Idioma |
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dc.contributor.author | Cerqueira, Bruno A. V. | - |
dc.contributor.author | Gonçalves, Marilda Souza | - |
dc.contributor.author | Vilas Boas, Wendell | - |
dc.contributor.author | Zanette, Angela Maria Dias | - |
dc.contributor.author | Reis, Mitermayer Galvão dos | - |
dc.creator | Cerqueira, Bruno A. V. | - |
dc.creator | Gonçalves, Marilda Souza | - |
dc.creator | Vilas Boas, Wendell | - |
dc.creator | Zanette, Angela Maria Dias | - |
dc.creator | Reis, Mitermayer Galvão dos | - |
dc.date.accessioned | 2012-02-07T19:02:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1096-0023 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/5317 | - |
dc.description | texto completo: acesso restrito. p.471–476. | pt_BR |
dc.description.abstract | Sickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis, frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, result- ing in painful crises, organ damage and premature death. This study evaluated associations between serum levels of IL-18, uric acid, hemolytic markers, and inflammatory molecules in SCA patients. A cross-sectional study was performed including 45 SCA patients (median age of 20.5 years) without gen- eral symptoms and who had not undergone blood transfusions. Inclusion criteria for the steady-state SCA patients were the absence of hospitalization and the absence of infections. Interleukin-18 and uric acid levels were correlated closely with markers of hemolysis, endothelial dysfunction and others cytokines levels. These findings suggest probable influences of IL-18 and uric acid in the pathophysiology of vascu- lar occlusion in SCA. Additional studies should be performed to characterize similar prognosis markers and possible therapeutic targets. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | doi:10.1016/j.cyto.2011.08.013 | pt_BR |
dc.subject | Sickle cell anemia | pt_BR |
dc.subject | Cytokine | pt_BR |
dc.subject | Inflammation | pt_BR |
dc.title | Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome | pt_BR |
dc.title.alternative | Cytokine | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 56. | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (FAR) |
Arquivo | Descrição | Tamanho | Formato | |
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__pdn.sciencedirect.com_....0-S1043466611006764-main.pdf Restricted Access | 263,86 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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