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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5305
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dc.contributor.authorSilva, Robson Amaro Augusto da-
dc.contributor.authorTavares, Natália Machado-
dc.contributor.authorCosta, Dirceu Joaquim-
dc.contributor.authorPitombo, Maiana Albuquerque-
dc.contributor.authorBarbosa, Larissa P.-
dc.contributor.authorFukutani, Kiyoshi Ferreira-
dc.contributor.authorMiranda, José Carlos-
dc.contributor.authorOliveira, Camila Indiani de-
dc.contributor.authorValenzuela, Jesus G.-
dc.contributor.authorBarral, Aldina Maria Prado-
dc.contributor.authorSoto, Manuel-
dc.contributor.authorBarral-Netto, Manoel-
dc.contributor.authorBrodskyn, Claudia Ida-
dc.creatorSilva, Robson Amaro Augusto da-
dc.creatorTavares, Natália Machado-
dc.creatorCosta, Dirceu Joaquim-
dc.creatorPitombo, Maiana Albuquerque-
dc.creatorBarbosa, Larissa P.-
dc.creatorFukutani, Kiyoshi Ferreira-
dc.creatorMiranda, José Carlos-
dc.creatorOliveira, Camila Indiani de-
dc.creatorValenzuela, Jesus G.-
dc.creatorBarral, Aldina Maria Prado-
dc.creatorSoto, Manuel-
dc.creatorBarral-Netto, Manoel-
dc.creatorBrodskyn, Claudia Ida-
dc.date.accessioned2012-02-06T18:09:59Z-
dc.date.issued2011-
dc.identifier.issn1873-6254-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/5305-
dc.descriptiontexto completo: acesso restrito. p. 185– 190.pt_BR
dc.description.abstractIt was recently shown that immunization of hamsters with DNA plasmids coding LJM19, a sand fly salivary protein, partially protected against a challenge with Leishmania chagasi, whereas immunization with KMP11 DNA plasmid, a Leishmania antigen, induced protection against L. donovani infection. In the present study, we evaluated the protective effect of immunization with both LJM19 and KMP11 DNA plasmid together. Concerning the protection against an infection by L. chagasi, immunization with DNA plasmids coding LJM19 or KMP11, as well as with both plasmids combined, induced IFN g production in draining lymph nodes at 7, 14 and 21 days postimmunization. Immunized hamsters challenged with L. chagasi plus Salivary Gland Sonicate (SGS) from Lutzomyia longipalpis showed an enhancement of IFN g/IL10 and IFN g/TGF b in draining lymph nodes after 7 and 14 days of infection. Two and five months after challenge, immunized animals showed reduced parasite load in the liver and spleen, as well as increased IFN g/IL10 and IFN g/TGF b ratios in the spleen. Furthermore, immunized animals remained with a normal hematological profile even five months after the challenge, whereas L. chagasi in unimmunized hamsters lead to a significant anemia. The protection observed with LJM19 or KMP11 DNA plasmids used alone was very similar to the protection obtained by the combination of both plasmids.pt_BR
dc.language.isoenpt_BR
dc.subjectHamsterpt_BR
dc.subjectLeishmania chagasipt_BR
dc.subjectVisceral leishmaniasispt_BR
dc.subjectSalivapt_BR
dc.subjectDNA plasmidspt_BR
dc.subjectProtectionpt_BR
dc.titleDNA vaccination with KMP11 and Lutzomyia longipalpis salivary protein protects hamsters against visceral leishmaniasispt_BR
dc.title.alternativeActa Tropicapt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 120.pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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