Campo DC | Valor | Idioma |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Porto, Maria Aurélia da Fonseca | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Porto, Maria Aurélia da Fonseca | - |
dc.date.accessioned | 2011-12-16T13:37:53Z | - |
dc.date.available | 2011-12-16T13:37:53Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1365-3024 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/4878 | - |
dc.description | p. 487–497 | pt_BR |
dc.description.abstract | Strongyloides stercoralis is the most common human parasitic nematode that is able to complete a life cycle and proliferate
within its host. The majority of patients with strongyloidiasis have an asymptomatic infection or mild disease. However,
when autoinfection occurs, a high number of infecting larvae can gain access to the bloodstream by penetrating the colonic
mucosa leading to a severe hyperinfection and the development of disseminated strongyloidiasis. The human T cell lymphotropic virus type 1 (HTLV-1) predominantly infects T cells and induces spontaneous lymphocyte proliferation and secretion of high levels of type 1 cytokines.
Strongyloides stercoralis patients with HTLV-1 co-infection have a modified immunological responses against parasite antigens and co-infection has clinical implications for strongyloidiasis. The
high production of IFN-γ observed in patients co-infected with HTLV-1 and Strongyloides stercoralis decreases the production of IL-4, IL-5, IL-13 and IgE, molecules that participate in the host defence mechanism against helminths. Moreover, there is a decrease in the efficacy of treatment of Strongyloides stercoralis in patients co-infected with HTLV-1. Alterations in the immune response against Strongyloides stercoralis and the decrease in the efficacy of anti-parasitic drugs are responsible for the increased
prevalence of Strongyloides stercoralis among HTLV-1 infected subjects and make HTLV-1 infection the most important risk
factor for disseminated strongyloidiasis. | pt_BR |
dc.language.iso | en | pt_BR |
dc.subject | helminths and HTLV-1 | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | human T cell lymphotropic virus type 1 | pt_BR |
dc.subject | Strongyloides stercoralis | pt_BR |
dc.subject | strongyloidiasis | pt_BR |
dc.title | Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis | pt_BR |
dc.title.alternative | Parasite Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 26 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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