Campo DC | Valor | Idioma |
dc.contributor.author | Schriefer, Nicolaus Albert Borges | - |
dc.contributor.author | Góes Neto, Aristóteles | - |
dc.contributor.author | Almeida, Roque Pacheco de | - |
dc.contributor.author | Carvalho, Lucas Pedreira de | - |
dc.contributor.author | Machado, Paulo Roberto Lima | - |
dc.contributor.author | Lessa, Hélio Andrade | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Jesus, Amélia Maria Ribeiro de | - |
dc.contributor.author | Riley, Lee Woodland | - |
dc.contributor.author | Schriefer, Ana L. F. | - |
dc.contributor.author | Guimarães, Luiz Henrique Santos | - |
dc.creator | Schriefer, Nicolaus Albert Borges | - |
dc.creator | Góes Neto, Aristóteles | - |
dc.creator | Almeida, Roque Pacheco de | - |
dc.creator | Carvalho, Lucas Pedreira de | - |
dc.creator | Machado, Paulo Roberto Lima | - |
dc.creator | Lessa, Hélio Andrade | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Jesus, Amélia Maria Ribeiro de | - |
dc.creator | Riley, Lee Woodland | - |
dc.creator | Schriefer, Ana L. F. | - |
dc.creator | Guimarães, Luiz Henrique Santos | - |
dc.date.accessioned | 2011-12-11T17:03:46Z | - |
dc.date.available | 2011-12-11T17:03:46Z | - |
dc.date.issued | 2004-01 | - |
dc.identifier.issn | 1098-5522 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/4794 | - |
dc.description | p. 508–514 | pt_BR |
dc.description.abstract | In Corte de Pedra (CP), northeastern Brazil, Leishmania braziliensis causes three distinct forms of American tegumentary leishmaniasis (ATL). To test the hypothesis that strain polymorphism may be involved in this
disease spectrum and accurately characterize the parasite population structure in CP, we compared one L. major, two non-CP L. braziliensis, one CP L. amazonensis, and 45 CP L. braziliensis isolates, obtained over a
10-year period from localized cutaneous, mucosal, and disseminated leishmaniasis patients, with randomly amplified polymorphic DNA (RAPD). Electrophoretic profiles were mostly unique across species. All typing
protocols revealed polymorphism among the 45 CP L. braziliensis isolates, which displayed eight different RAPD patterns and greater than 80% overall fingerprint identity, attesting to the adequacy of the tools to
assess strain variability in CP’s geographically limited population of parasites. The dendrogram based on the
sum of RAPD profiles of each isolate unveiled nine discrete typing units clustered into five clades. Global positioning showed extensive overlap of these clades in CP, precluding geographic sequestration as the
mechanism of the observed structuralization. Finally, all forms of ATL presented a statistically significant difference in their frequencies among the clades, suggesting that L. braziliensis genotypes may be accompanied
by specific disease manifestation after infection. | pt_BR |
dc.language.iso | en | pt_BR |
dc.title | Multiclonal Leishmania braziliensis Population Structure and Its Clinical Implication in a Region of Endemicity for American Tegumentary Leishmaniasis | pt_BR |
dc.title.alternative | Infection and Immunity | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v.72, n. 1. | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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