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https://repositorio.ufba.br/handle/ri/4783
metadata.dc.type: | Artigo de Periódico |
Título : | Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies |
Otros títulos : | International Urology and Nephrology |
Autor : | Athanazio, Daniel Abensur Sweet, Gloria Maria Maranhão Silva, Carlos Alberto Santos, Washington Luis Conrado dos |
metadata.dc.creator: | Athanazio, Daniel Abensur Sweet, Gloria Maria Maranhão Silva, Carlos Alberto Santos, Washington Luis Conrado dos |
Resumen : | Chronic lesions in renal biopsies are a well recognized prognostic factor for renal diseases, including lupus nephritis. The methods used for assessment of chronic lesions are, however, largely based on semiquantitative evaluation and may lead to poor reproducibility. Interobserver variation is particularly important in lupus nephritis, in which acute and chronic lesions may occur simultaneously. In this study we tested the reproducibility of chronic lesion assessment performed by three pathologists, two with specific training in renal pathology, using 20 renal biopsies and a standard semiquantitative method. In a second experiment, we evaluated the reproducibility of chronic lesion assessment in 33 biopsies of lupus nephritis by the two nephropathologists. The semiquantitative estimated values were compared with those from a previously proposed morphometric method for quantification of chronic lesions in renal biopsies. Although correlations were observed among the estimated values, there was a wide range of variation when semiquantitative methods were used. In particular, activity and chronicity indices of lupus nephritis were poorly reproducible. In contrast, use of a morphometric score, although not eliminating interobserver variability, led to better reproducibility of estimated values than that obtained with semiquantitative methods. |
Palabras clave : | Lupus nephritis Kidney Renal biopsy Reproducibility of results Interstitial fibrosis |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/4783 |
Fecha de publicación : | 2009 |
Aparece en las colecciones: | Artigo Publicado em Periódico (ICS) |
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