Lesão hepática induzida por produto emagrecedor irregular: relato de caso

Abstract

Drug-induced liver injury (DILI) is a rare but potentially serious condition that is often underdiagnosed due to the nonspecific nature of its symptoms and patients’ failure to report the use of substances, in addition to the need to rule out other causes of liver injury. This paper reports the case of a 39-year-old female patient admitted with acute hepatocellular injury of initially unknown cause. After a thorough investigation, the use of a natural weight-loss supplement was identified. Mass spectrometry analysis revealed undeclared synthetic compounds such as sibutramine, bupropion, and fluoxetine. The causality assessment using the RUCAM method indicated a highly probable diagnosis of DILI. The patient experienced full clinical and laboratory recovery after discontinuing the product and receiving symptomatic treatment, without the need for a liver biopsy. This case highlights the risks associated with the use of irregular supplements and emphasizes the importance of a thorough medical history, early diagnosis, and strict health surveillance.