| dc.relation.references | ABBAS, Abul. Imunologia celular e molecular. 7. ed. Elsevier Brasil, 2012.
AKILOV, Oleg E. et al. The role of mannose receptor during experimental leishmaniasis.
Journal of Leucocyte Biology, v. 81, n. 5, p. 1188-1196, 2007.
ALEIXO, J. A. et al. Atypical American visceral leishmaniasis caused by disseminated
Leishmania amazonensis infection presenting with hepatitis and adenopathy. Transactions of
the Royal Society of Tropical Medicine and Hygiene, v. 100, n. 1, p. 79-82, 2006.
ALEXANDER, J.; RUSSELL, D. G. The Interaction of Leishmania Species with Macrophages.
Advances in Parasitology, v. 31, no. C, p. 175–254, 1 Jan. 1992.
AMPREY, Joseph L.; SPÄTH, Gerald F.; PORCELLI, Steven A. Inhibition of CD1 expression
in human dendritic cells during intracellular infection with Leishmania donovani. Infection
and Immunity, v. 72, n. 1, p. 589-592, 2004.
ANAND-APTE, Bela et al. Platelet-derived growth factor and fibronectin-stimulated migration
are differentially regulated by the Rac and extracellular signal-regulated kinase
pathways. Journal of Biological Chemistry, v. 272, n. 49, p. 30688-30692, 1997.
ASHFORD, R.W. The leishmaniases as emerging and reemerging zoonoses. International
Journal for Parasitology, vol. 30, no. 12–13, p. 1269–1281, Nov. 2000.
ATO, Manabu et al. Defective CCR7 expression on dendritic cells contributes to the
development of visceral leishmaniasis. Nature Immunology, v. 3, n. 12, p. 1185-1191, 2002.
ATO, Manabu et al. Loss of dendritic cell migration and impaired resistance to Leishmania
donovani infection in mice deficient in CCL19 and CCL21. The Journal of Immunology, v.
176, n. 9, p. 5486-5493, 2006.
BARRAL, A. et al. Isolation of Leishmania mexicana amazonensis from the bone marrow in a
case of American visceral leishmaniasis. The American Journal of Tropical Medicine and
Hygiene, v. 35, n. 4, p. 732-734, 1986.
BARRAL, Aldina et al. Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis
produces a wide spectrum of clinical disease. Am. J. Trop. Med. Hyg, v. 44, n. 5. p. 536-546,
1991.
BECKER, Ingeborg et al. Leishmania lipophosphoglycan (LPG) activates NK cells through
toll-like receptor-2. Molecular and Biochemical Parasitology, v. 130, n. 2, p. 65-74, 2003.
BEINHAUER, Brigitte G. et al. Interleukin 10 regulates cell surface and soluble LIR‐2
(CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro.
European journal of Immunology, v. 34, n. 1, p. 74-80, 2004.
BELLIS, Susan L. et al. Adhesion of fibroblasts to fibronectin stimulates both serine and
tyrosine phosphorylation of paxillin. Biochemical Journal, v. 325, n. 2, p. 375-381, 1997.
69
BENNETT, Clare L. et al. Silent infection of bone marrow‐derived dendritic cells by
Leishmania mexicana amastigotes. European journal of Immunology, v. 31, n. 3, p. 876-883,
2001.
BERMAN, J. D. Human Leishmaniasis: Clinical, Diagnostic, and hemotherapeutic
Developments in the Last 10 Years. Clinical Infectious Diseases, v. 24, n. 4, p. 684-703, 1997.
BEVERLEY, Stephen M.; TURCO, Salvatore J. Lipophosphoglycan (LPG) and the
identification of virulence genes in the protozoan parasite Leishmania. Trends in
Microbiology, v. 6, n. 1, p. 35-40, 1998.
BLACKWELL, JENEFER M. et al. Macrophage complement and lectin-like receptors bind
Leishmania in the absence of serum. The Journal of Experimental Medicine, v. 162, n. 1, p.
324-331, 1985.
BLANDER, J. Magarian; MEDZHITOV, Ruslan. Toll-dependent selection of microbial
antigens for presentation by dendritic cells. Nature, v. 440, n. 7085, p. 808-812, 2006.
BOGGIATTO, Paola Mercedes et al. Altered dendritic cell phenotype in response to
Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK. The
American Journal of Pathology, v. 174, n. 5, p. 1818-1826, 2009.
BRANDONISIO, Olga; SPINELLI, Rosa; PEPE, Maria. Dendritic cells in Leishmania
infection. Microbes and Infection, v. 6, n. 15, p. 1402-1409, 2004.
BRAY, R. S. et al. The effect of parasitization by Leishmania mexicana mexicana on
macrophage function in vitro. Acta Trop., n, v. 40, n. 1, 1983.
BRASIL. Ministério da Saúde. Situação epidemiológica da Leishmaniose Visceral. Brasil,
DF: MS, 2022. Disponível em: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-az/l/leishmaniose-visceral/situacao-epidemiologica-da-leishmaniose-visceral. Acesso em: 08
mar. 2024.
BRITO, Reginaldo et al. Leishmania amazonensis infection impairs VLA-4 clustering and
adhesion complex assembly at the adhesion site of J774 cells. Pathogens and Disease, v. 81,
p. ftad013, 2023.
BRITTINGHAM, Andrew et al. Interaction of Leishmania gp63 with cellular receptors for
fibronectin. Infection and Immunity, v. 67, n. 9, p. 4477-4484, 1999.
BROWN, M. C.; TURNER, C. E. Paxillin: adapting to change. Physiological Reviews, v. 84,
n. 4, 2004.
BURZA, S., CROFT, S. L., BOELAET, M. Leishmaniasis. The Lancet, vol. 18, n. 2, 2018.
CARVALHAL, D. G. et al. The modelling of mononuclear phagocyte—connective tissue
adhesion in vitro: application to disclose a specific inhibitory effect of Leishmania infection.
Experimental Parasitology, v. 107, n. 3-4, 2004.
70
CARVALHO, Lucas P. et al. Lymph node hypertrophy following Leishmania major infection
is dependent on TLR9. The Journal of Immunology, v. 188, n. 3, p. 1394-1401, 2012.
CHANG, Chiung-Fang et al. Polar opposites: Erk direction of CD4 T cell subsets. The Journal
of Immunology, v. 189, n. 2, p. 721-731, 2012.
CHEN, Gang; DARRAH, Patricia A.; MOSSER, David M. Vaccination against the
intracellular pathogens Leishmania major and L. amazonensis by directing CD40 ligand to
macrophages. Infection and Immunity, v. 69, n. 5, p. 3255-3263, 2001.
COELHO-FINAMORE, J. M. et al. Leishmania infantum: Lipophosphoglycan intraspecific
variation and interaction with vertebrate and invertebrate hosts. International Journal for
Parasitology, v. 41, n. 3-4, p. 333-342, 2011.
COLMENARES, M. et al. Mechanisms of pathogenesis: differences amongst Leishmania
species. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 96, n. 1,
p. 3-7, 2002.
CONCEIÇÃO-SILVA, F; MOGADO, F. N. Leishmania Spp-Host Interaction: There Is Always
an Onset,but Is There an End? Frontiers in Cellular and Infection Microbiology, v. 9, n. 330,
p. 1-14, 2019.
COOK, J. H; UENO, N; LODOEN, M. B. Toxoplasma gondii disrupts β1 integrin signaling
and focal adhesion formation during monocyte hypermotility. The Jornal of Biological
Chemistry, v. 293, n. 9, 2018.
COSTA, C. H. et al. Competence of the human host as a reservoir for Leishmania chagasi. The
jornal of Infectious Diseases, v. 182, n. 3, p. 997-1000, 2000.
Da GAMA, L. M. et al. Reduction in adhesiveness to extracellular matrix components,
modulation of adhesion molecules and in vivo migration of murine macrophages infected with
Toxoplasma gondii. Microbes and Infection, v. 6, n. 14, 2004.
DE ASSIS, R. R. et al. Glycoconjugates in New World species of Leishmania: Polymorphisms
in lipophosphoglycan and glycoinositolphospholipids and interaction with hosts. Biochimica
et Biophysica Acta - General Subjects, v. 1820, n. 9, p.1354–1365, 2012.
De MENEZES, J. P. B. et al. Leishmania infection inhibits macrophage motility by altering Factin dynamics and the expression of adhesion complex proteins. Cellular Microbiology, v.
19, n. 3, 2016.
DE TREZ, Carl et al. iNOS-producing inflammatory dendritic cells constitute the major
infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant
mice. PLoS Pathogens, v. 5, n. 6, p. e1000494, 2009.
DE VEER, Michael J. et al. MyD88 is essential for clearance of Leishmania major: possible
role for lipophosphoglycan and Toll‐like receptor 2 signaling. European Journal Of
Immunology, v. 33, n. 10, p. 2822-2831, 2003.
DEAKIN, N. O.; TURNER, C. E. Paxillin comes of age. Journal of Cell Science, v. 121, n.
15, p. 2435–2444, 2008.
71
DEAKIN, N. O; TURNER, C. E. Paxillin comes of age. Journal of Cell Science, v. 121, n. 15,
2008.
DERAMAUDT, T. B.; DUJARDIN, D.; NOULET, F.; MARTIN, S.; VAUCHELLES, R.;
TAKEDA, K.; RONDE, P. Altering FAK-paxillin interactions reduces adhesion, migration and
invasion processes. Plos One, 2014.
DERMINE, Jean‐François et al. Leishmania promastigotes require lipophosphoglycan to
actively modulate the fusion properties of phagosomes at an early step of phagocytosis.
Cellular Microbiology, v. 2, n. 2, p. 115-126, 2000.
DESCOTEAUX, Albert; TURCO, Salvatore J. Glycoconjugates in Leishmania infectivity.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, v. 1455, n. 2-3, p. 341-
352, 1999.
DESJARDINS, Michel; DESCOTEAUX, Albert. Inhibition of phagolysosomal biogenesis by
the Leishmania lipophosphoglycan. The Journal of Experimental Medicine, v. 185, n. 12, p.
2061-2068, 1997.
DESJEUX, P. Leishmaniasis: Current situation and new perspectives. Comparative
Immunology, Microbiology and Infectious Diseases, vol. 27, no. 5, p. 305–318, 2004.
DOSTÁLAVA, A; VOLF, P. Leishmania development in sand flies: parasite-vector
interactions overview. Parasites & Vectors, v. 5, n. 276, 2012.
DUAN, Tianhao et al. Toll-like receptor signaling and its role in cell-mediated immunity.
Frontiers in Immunology, v. 13, p. 812774, 2022.
E SOUSA, Caetano Reis. Activation of dendritic cells: translating innate into adaptive
immunity. Current Opinion In Immunology, v. 16, n. 1, p. 21-25, 2004.
FEIJÓ, Daniel et al. Dendritic cells and Leishmania infection: adding layers of complexity to a
complex disease. Journal of Immunology Research, v. 2016, 2016.
FERGUSON, Michael AJ. The structure, biosynthesis and functions of
glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. Journal
of Cell Science, v. 112, n. 17, p. 2799-2809, 1999.
FERNANDEZ-FLORES, A.; RODRIGUEZ-PERALTO, J. L. Morphological and
immunohistochemical clues for the diagnosis of cutaneous leishmaniasis and the interpretation
of cd1a status. Journal of the American Acadmy of Dermatoly, v. 74, n. 3, 2016.
FORESTIER, Claire-Lise; GAO, Qi; BOONS, Geert-Jan. Leishmania lipophosphoglycan: how
to establish structure-activity relationships for this highly complex and multifunctional
glycoconjugate?. Frontiers in cellular and Infection Microbiology, v. 4, p. 193, 2015.
FOXALL, E.; PIPILI, A.; JONES, G. E.; WELLS, C. M. Significance of kinase activity in the
dynamic invadosome. European Journal of Cell Biology, v. 95, n. 11, p. 483-492, nov. 2016.
72
FRANCO, L. H.; BEVERLEY, S. M.; ZAMBONI, D. S. Innate immune activation and
subversion of mammalian functions by Leishmania lipophosphoglycan. Journal of
Parasitology Research, v. 2012.
FRANKENBURG, S.; GROSS, A.; LEIBOVICI V. Leishmania major and Leishmania
donovani: Effect of LPG-Containing and LPG-Deficient Strains on Monocyte Chemotaxis and
Chemiluminescence. Experimental Parasitology, v. 75, n. 1, 1992.
GAUR, Upasna et al. Leishmania donovani lacking the Golgi GDP-Man transporter LPG2
exhibit attenuated virulence in mammalian hosts. Experimental Parasitology, v. 122, n. 3, p.
182-191, 2009.
GEISSMANN, Frédéric et al. Unravelling mononuclear phagocyte heterogeneity. Nature
Reviews Immunology, v. 10, n. 6, p. 453-460, 2010.
GLADING, A. et al. Epidermal growth factor activates m-calpain (calpain II), at least in part,
by extracellular signal-regulated kinase-mediated phosphorylation. Molecular and Cellular
Biology, 2004.
GOLEY, E. D.; WELCH, M. D. The ARP2/3 complex: an actin nucleator comes of age. Nature
Reviews Molecular Cell Biology, v. 7, n. 10, 2006.
GORAK, Patricia MA; ENGWERDA, Christian R.; KAYE, Paul M. Dendritic cells, but not
macrophages, produce IL‐12 immediately following Leishmania donovani infection.
European Journal Of Immunology, v. 28, n. 2, p. 687-695, 1998.
GORAK, Patricia MA; ENGWERDA, Christian R.; KAYE, Paul M. Dendritic cells, but not
macrophages, produce IL‐12 immediately following Leishmania donovani infection.
European Journal Of Immunology, v. 28, n. 2, p. 687-695, 1998.
GUEIRARD, Pascale et al. Trafficking of Leishmania donovani promastigotes in non‐lytic
compartments in neutrophils enables the subsequent transfer of parasites to
macrophages. Cellular Microbiology, v. 10, n. 1, p. 100-111, 2008.
HARKER, K. S. et al. Toxoplasma gondii modulates the dynamics of human monocyte
adhesion to vascular endothelium under fluidic shear stress. Journal of Leukocyte Biology, v.
93, n. 5, 2013.
HERMIDA, M. D. R. et al. Leishmania amazonensis infection impairs dendritic cell migration
from the inflammatory site to the draining lymph node. BMC Infectious Diseases. v. 14, n.
450, 2014.
HERNÁNDEZ, Dimas E. et al. Visceral leishmaniasis due to a Leishmania variant that shares
kinetoplast DNA sequences with Leishmania braziliensis and Leishmania mexicana in a patient
infected with human immunodeficiency virus: identification of the Leishmania species with use
of the polymerase chain reaction. 1995.
HERWALDT, B. L. Leishmaniasis. Lancet, v.354, n.9185, p. 1191-1199,1999.
73
HONG, Wenxiang et al. New insights of CCR7 signaling in dendritic cell migration and
inflammatory diseases. Frontiers in Pharmacology, v. 13, p. 841687, 2022.
HSU, Alice C.; SCOTT, Phillip. Leishmania mexicana infection induces impaired lymph node
expansion and Th1 cell differentiation despite normal T cell proliferation. The Journal of
Immunology, v. 179, n. 12, p. 8200-8207, 2007.
HUNGER-GLASER, Isabel et al. Bombesin, lysophosphatidic acid, and epidermal growth
factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK
activation. Journal of Biological Chemistry, v. 278, n. 25, p. 22631-22643, 2003.
HURRELL, Benjamin P. et al. Rapid sequestration of Leishmania mexicana by neutrophils
contributes to the development of chronic lesion. PLoS Pathogens, v. 11, n. 5, p. e1004929,
2015.
HUTTENLOCHER, Anna; HORWITZ, Alan Rick. Integrins in cell migration. Cold Spring
Harbor Perspectives In Biology, v. 3, n. 9, p. a005074, 2011.
HUVENEERS, S.; DANEN, E. H. J. Adhesion signaling - Crosstalk between integrins, Src and
Rho. Journal of Cell Science, vol. 122, no. 8, p. 1059–1069, 15 Apr. 2009.
HYNES, R. O. Integrins: Bidirectional, allosteric signaling machines. Cell, vol. 110, no. 6, p.
673–687, 20 Sep. 2002.
IBRAHIM, M. E., BARKER, D. C. The origin and Evolution of the Leishmania donovani
complex a inferred from a mitochondrial cytochrome oxidase II gene sequence. Infection,
Genetics and Evolution, v.1, n.1, p. 61-68, 2001.
IBRAHIM, Marwa K. et al. Deficiency of lymph node-resident dendritic cells (DCs) and
dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani
infection. Infection and Immunity, v. 82, n. 8, p. 3098-3112, 2014.
IBRAIM, Izabela Coimbra et al. Two biochemically distinct lipophosphoglycans from
Leishmania braziliensis and Leishmania infantum trigger different innate immune responses in
murine macrophages. Parasites & Vectors, v. 6, p. 1-11, 2013.
ILG, Thomas. Lipophosphoglycan is not required for infection of macrophages or mice by
Leishmania mexicana. The EMBO journal, v. 19, n.1, p. 1953-1962, 2000.
ILG, Thomas; DEMAR, Monika; HARBECKE, Dorothee. Phosphoglycan repeat-deficient
Leishmania mexicana parasites remain infectious to macrophages and mice. Journal of
Biological Chemistry, v. 276, n. 7, p. 4988-4997, 2001.
ITO, Tomoki et al. Interferon-α and interleukin-12 are induced differentially by Toll-like
receptor 7 ligands in human blood dendritic cell subsets. The Journal of Experimental
Medicine, v. 195, n. 11, p. 1507-1512, 2002.
JEBBARI, Heather et al. Leishmania major promastigotes inhibit dendritic cell motility in vitro.
Infection and Immunity, v. 70, n. 2, p. 1023-1026, 2002.
74
JESUS-SANTOS, Flávio Henrique et al. LPG2 gene duplication in Leishmania infantum: A
case for CRISPR-Cas9 gene editing. Frontiers in Cellular and Infection Microbiology, v.
10, p. 408, 2020.
KAVOOSI, G.; ARDESTANI, S. K.; KARIMINIA, A. The involvement of TLR2 in cytokine
and reactive oxygen species (ROS) production by PBMCs in response to Leishmania major
phosphoglycans (PGs). Parasitology, v. 136, n. 10, p. 1193-1199, 2009.
KAWAI, Taro; AKIRA, Shizuo. The role of pattern-recognition receptors in innate immunity:
update on Toll-like receptors. Nature Immunology, v. 11, n. 5, p. 373-384, 2010.
KHAITLINA, S.; FITZ, H.; HINSSEN, H. The interaction of gelsolin with tropomyosin
modulates actin dynamics. FEBS Journal, vol. 280, no. 18, p. 4600–4611, Sep. 2013.
KIMA, Peter E. et al. Internalization of Leishmania mexicana complex amastigotes via the Fc
receptor is required to sustain infection in murine cutaneous leishmaniasis. The Journal of
Experimental Medicine, v. 191, n. 6, p. 1063-1068, 2000.
KLEMKE, Richard L. et al. Regulation of cell motility by mitogen-activated protein
kinase. The Journal of Cell Biology, v. 137, n. 2, p. 481-492, 1997.
KOMAI‐KOMA, Mousa et al. Anti‐Toll‐like receptor 2 and 4 antibodies suppress
inflammatory response in mice. Immunology, v. 143, n. 3, p. 354-362, 2014.
KONECNY, Pamela et al. Murine dendritic cells internalize Leishmania major promastigotes,
produce IL‐12 p40 and stimulate primary T cell proliferation in vitro. European Journal of
Immunology, v. 29, n. 6, p. 1803-1811, 1999.
KROPF, Pascale et al. Toll-like receptor 4 contributes to efficient control of infection with the
protozoan parasite Leishmania major. Infection and Immunity, v. 72, n. 4, p. 1920-1928,
2004.
LAI, Chung-Fang et al. Erk is essential for growth, differentiation, integrin expression, and cell
function in human osteoblastic cells. Journal of Biological Chemistry, v. 276, n. 17, p. 14443-
14450, 2001.
LAI, G. N. et al. Migratory dermal dendritic cells act as rapid sensors of protozoan parasites.
PLoS Pathogens, v. 4, p. 11, 2008.
LÁZARO-SOUZA, Milena et al. Leishmania infantum lipophosphoglycan-deficient mutants:
a tool to study host cell-parasite interplay. Frontiers in microbiology, v. 9, p. 626, 2018.
LECOEUR, Hervé et al. Leishmania amazonensis subverts the transcription factor landscape
in dendritic cells to avoid inflammasome activation and stall maturation. Frontiers in
immunology, v. 11, p. 1098, 2020.
LEMOS, Maria P. et al. MHC class II expression restricted to CD8α+ and CD11b+ dendritic
cells is sufficient for control of Leishmania major. The Journal of experimental medicine, v.
199, n. 5, p. 725-730, 2004.
75
LEÓN B, LÓPEZ-BRAVO M, ARDAVÍN C. Monocyte-Derived Dendritic Cells Formed at
the Infection Site Control the Induction of Protective T Helper 1 Responses Against
Leishmania. Immunity. V. 26, n.4, 2007.
LEON, B. et al. Monocyte-Derived Dendritic Cells Formed at the Infection Site Control the
Induction of Protective T Helper 1 Responses against Leishmania. Immunity, v. 26, n. 4, p.
519–531, 2007.
LEÓN, B.; LÓPEZ-BRAVO, M.; ARDAVÍN, C. Monocyte-Derived Dendritic Cells Formed
at the Infection Site Control the Induction of Protective T Helper 1 Responses against
Leishmania. Immunity, vol. 26, no. 4, p. 519–531, 2007.
LEY, K. et al. Getting to the site of inflammation: the leukocyte adhesion cascade updated.
Nature Reviews Immunology, v. 7, n. 9, 2007.
LIESE, Jan et al. TLR9 signaling is essential for the innate NK cell response in murine
cutaneous leishmaniasis. European Journal Of Immunology, v. 37, n. 12, p. 3424-3434,
2007.
LIMA, Jonilson Berlink et al. Leishmania infantum lipophosphoglycan induced-Prostaglandin
E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and
2. Scientific Reports, v. 7, n. 1, p. 14321, 2017.
LINDER, Stefan; AEPFELBACHER, Martin. Podosomes: adhesion hot-spots of invasive cells.
Trends in Cell Biology, v. 13, n. 7, p. 376-385, 2003.
LINDER, Stefan; KOPP, Petra. Podosomes at a glance. Journal Of Cell Science, v. 118, n. 10,
p. 2079-2082, 2005.
LISI, Sabrina et al. Infection with Leishmania infantum Inhibits actinomycin D‐induced
apoptosis of human monocytic cell line U‐937. Journal of Eukaryotic Microbiology, v. 52,
n. 3, p. 211-217, 2005.
LIU, Dong; UZONNA, Jude E. The early interaction of Leishmania with macrophages and
dendritic cells and its influence on the host immune response. Frontiers in Cellular and
Infection Microbiology, v. 2, p. 83, 2012.
LIU, Zhen-Xiang et al. Hepatocyte growth factor induces ERK-dependent paxillin
phosphorylation and regulates paxillin-focal adhesion kinase association. Journal of
Biological Chemistry, v. 277, n. 12, p. 10452-10458, 2002.
LODGE, Robert; DESCOTEAUX, Albert. Leishmania donovani promastigotes induce
periphagosomal F‐actin accumulation through retention of the GTPase Cdc42. Cellular
microbiology, v. 7, n. 11, p. 1647-1658, 2005.
LÓPEZ-COLOMÉ, A. M.; LEE-RIVERA, I.; BENAVIDES-HIDALGO, R.; LÓPEZ, E.
Paxillin: A crossroad in pathological cell migration. Journal of Hematology and Oncology,
vol. 10, no. 1, 18 Feb. 2017.
76
LUKES, J. et al. Evolutionary and geographical history of the Leishmania donovani complex
with a revision of current taxonomy. Proceedings of the National Academy of Sciences of
the USA, v. 104, n. 22, p. 9375-9380, 2007.
MACRI, Christophe et al. Dendritic cell subsets. Seminars In Cell & Developmental Biology.
Academic Press, p.11-21, 2018..
MARTINEZ, P. A.; PETERSEN, C. A. Chronic infection by Leishmania amazonensis
mediated through MAPK ERK mechanisms. Immunol Res. v.153, n.65, 2014.
MARTINO, J.; HENRIET, E.; EZZOUKHRY, Z.; GOETZ, J. G.; MOREAU, V.; SALTEL, F.
The microenvironment controls invadosome plasticity. Journal of Cell Science, v. 129, n. 9,
p. 1759-1768, 2016.
MCCOLL, S. R. Chemokines and dendritic cells: a crucial alliance. Immunology Cell Biology,
v. 80, p. 489-496, 2002.
MCCONVILLE, Malcolm J.; FERGUSON, M. A. The structure, biosynthesis and function of
glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes.
Biochemical Journal, v. 294, n. Pt 2, p. 305, 1993.
MCGOUGH, A. M.; STAIGER, C. J.; MIN, J. K.; SIMONETTI, K. D. The gelsolin family of
actin regulatory proteins: Modular structures, versatile functions. FEBS Letters, vol.552, no. 2–
3, p. 75–81, 25 Sep. 2003.
MELO, T. G. et al. Trypanosoma cruzi down-regulates mechanosensitive proteins in
cardiomyocytes. Memórias do Instituto Oswaldo Cruz, v. 114, p. e180593, 2019.
MERAD, Miriam et al. The dendritic cell lineage: ontogeny and function of dendritic cells and
their subsets in the steady state and the inflamed setting. Annual Review Of Immunology, v.
31, p. 563-604, 2013.
MISHRA, Y. G.; MANAVATHI, B. Focal adhesion dynamics in cellular function and disease.
Cellular Signalling, v.85, n.110046, 2021.
MISSLITZ, A. C. et al. Two waves of antigen-containing dendritic cells in vivo in experimental
Leishmania major infection. European Journal of Immunology, v. 34, p. 715-725, 2004.
MITRA, S. K.; HANSON, D. A.; SCHLAEPFER, D. D. Focal adhesion kinase: in command
and control of cell motility. Nature Reviews Molecular Cell Biology, v, 6, n.1, 2005.
MITRA, S. K.; SCHLAEPFER, D. D. Integrin-regulated FAK-Src signaling in normal and
cancer cells. Current Opinion in Cell Biology, vol. 18, no. 5, p. 516–523, Oct. 2006.
MOLL, H.; FUCHS, H.; BLANK, C.; RÖLLINGHOFF, M. Langerhans cells transport
Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐
specific T cells. European Journal of Immunology, vol. 23, no. 7, p. 1595–1601, 1993.
MOLL, Heidrun et al. Dendritic cells in Leishmania major‐immune mice harbor persistent
parasites and mediate an antigen‐specific T cell immune response. European Journal Of
Immunology, v. 25, n. 3, p. 693-699, 1995.
77
MOLL, Heidrun. Dendritic cells and host resistance to infection. Cellular Microbiology, v. 5,
n. 8, p. 493-500, 2003.
MOLL, Heidrun; SCHARNER, Anabel; KÄMPGEN, Eckhart. Increased interleukin 4 (IL-4)
receptor expression and IL-4-induced decrease in IL-12 production by Langerhans cells
infected with Leishmania major. Infection and Immunity, v. 70, n. 3, p. 1627-1630, 2002.
MOORE, Kathryn J.; MATLASHEWSKI, Greg. Intracellular infection by Leishmania
donovani inhibits macrophage apoptosis. Journal of Immunology (Baltimore, Md.: 1950), v.
152, n. 6, p. 2930-2937, 1994.
MOSMANN, Tim R. et al. T helper cytokine patterns: defined subsets, random expression, and
external modulation. Immunologic Research, v. 45, p. 173-184, 2009.
MURAILLE, Eric et al. Amastigote load and cell surface phenotype of infected cells from
lesions and lymph nodes of susceptible and resistant mice infected with Leishmania major.
Infection and Immunity, v. 71, n. 5, p. 2704-2715, 2003.
MURAILLE, Eric et al. Genetically resistant mice lacking MyD88-adapter protein display a
high susceptibility to Leishmania major infection associated with a polarized Th2 response.
The Journal of Immunology, v. 170, n. 8, p. 4237-4241, 2003.
MURPHY, D. A.; COURTNEIDGE, S. A. The “ins” and “outs” of podosomes and
invadopodia: characteristics, formation and function. Nature Reviews Molecular Cell
Biology, v. 12, n. 7, p. 413-426, 23 jun. 2011.
MURRAY, H. W. et al. Advances in leishmaniasis. The Lancet, v. 366, n. 9496, p. 1561 -
1577, 2005.
NAGAO, T. et al. Elevated Cholesterol Levels in the Plasma Membranes of Macrophages
Inhibit Migration by Disrupting RhoA Regulation. Arteriosclerosis, Thrombosis, and
Vascular Biology, v.27, n.72007
NAIR-GUPTA, Priyanka et al. TLR signals induce phagosomal MHC-I delivery from the
endosomal recycling compartment to allow cross-presentation. Cell, v. 158, n. 3, p. 506-521,
2014.
NG, Lai Guan et al. Migratory dermal dendritic cells act as rapid sensors of protozoan parasites.
PLoS Pathogens, v. 4, n. 11, p. e1000222, 2008.
OHL, L. et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state
conditions. Immunity, v.2, n.7, p. 279-288, 2004.
OLMOS, S. et al. Ectopic Activation of Mycobacterium tuberculosis-Specific CD4+ T Cells in
Lungs of CCR72/2 Mice. Journal of Immunology, v. 184, n.1, p. 895-901, 2009.
ORGANIZAÇÃO MUNDIAL DA SAÚDE. Leishmaniasis. [S. l.]: OMS, 2023. Disponível
em: https://www.who.int/news-room/fact-sheets/detail/leishmaniasis. Acesso em: 27 jan. 2024.
78
ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE. Leishmanioses. Informe
Epidemiológico das Américas, n. 10, OPAS, 2021. Disponível em:
https://iris.paho.org/handle/10665.2/55386. Acesso em: 27 jan. 2024.
PALUCH, E. K.; ASPALTER, I. M.; SIXT, M. Focal Adhesion–Independent Cell Migration.
Annual Review of Cell and Developmental Biology, v. 32, n. 1, 2016.
PETERS, N. C. et al. In Vivo Imaging Reveals an Essential Role for Neutrophils in
Leishmaniasis Transmitted by Sand Flies. Science, v. 321, n. 5891, p. 970-974 2008.
PETERS, Nathan C.; SACKS, David L. The impact of vector‐mediated neutrophil recruitment
on cutaneous leishmaniasis. Cellular Microbiology, v. 11, n. 9, p. 1290-1296, 2009.
PETRITUS, Patricia M. et al. Leishmania mexicana induces limited recruitment and activation
of monocytes and monocyte-derived dendritic cells early during infection. Plos Neglected
Tropical Diseases, v. 6, n. 10, 2012.
PINHEIRO, N. F. et al. Leishmania infection impairs beta 1-integrin function and chemokine
receptor expression in mononuclear phagocytes. Infection Immunity, v. 74, n. 7, 2006.
PLAYFORD, M. P.; SCHALLER, M. D. The interplay between Src and integrins in normal
and tumor biology. Oncogene, vol. 23, n. 48, p. 7928–7946, 18 Oct. 2004.
PODINOVSKAIA, M.; DESCOTEAUX, A. Leishmania and the macrophage: a multifaceted
interaction. Future Microbiology, vol. 10, no. 1, p. 111–129, 2015.
PONTE‐SUCRE, Alicia; HEISE, Dirk; MOLL, Heidrun. Leishmania major lipophosphoglycan
modulates the phenotype and inhibits migration of murine Langerhans cells. Immunology, v.
104, n. 4, p. 462-467, 2001.
PORTO, Victor Bertolo Gomes et al. Visceral leishmaniasis caused by Leishmania
(Leishmania) amazonensis associated with Hodgkin’s lymphoma. Revista do Instituto de
Medicina Tropical de São Paulo, v. 64, p. e51, 2022.
PRINA, Eric et al. Dendritic cells as host cells for the promastigote and amastigote stages of
Leishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation.
Journal of Cell Science, v. 117, n. 2, p. 315-325, 2004.
PUENTES, S. M. et al. Binding and release of C3 from Leishmania donovani promastigotes
during incubation in normal human serum. Journal of Immunology, v. 143, n. 11, p. 3743-
3749, 1989.
QUINONES, Marlon et al. Preformed membrane-associated stores of interleukin (IL)-12 are a
previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact
with an intracellular parasite. The Journal of Experimental Medicine, v. 192, n. 4, p. 507-
516, 2000.
QUINTELA-CARVALHO, Graziele et al. Leishmania infantum defective in
lipophosphoglycan biosynthesis interferes with activation of human neutrophils. Frontiers in
cellular and infection microbiology, v. 12, p. 788196, 2022.
79
QUINTELA-CARVALHO, Graziele et al. Leishmania infantum defective in
lipophosphoglycan biosynthesis interferes with activation of human neutrophils. Frontiers in
cellular and infection microbiology, v. 12, p. 788196, 2022.
RAFTOPOULO, M.; HALL. A. Cell migration: Rho GTPases lead the way.Developmental
Biology, v. 265, n. 1, 2004.
RAMOS-SANTOS, Carmen et al. Visceral leishmaniosis caused by Leishmania (L.) mexicana
in a Mexican patient with human immunodeficiency virus infection. Memorias do Instituto
Oswaldo Cruz, v. 95, p. 733-738, 2000.
REBOUÇAS, A. et al. Leishmania-Induced Dendritic Cell Migration and Its Potential
Contribution to Parasite Dissemination. Microoganisms, v. 9, n, 1268, 2021.
RIDLEY, A, J. Rho GTPase signalling in cell migration. Current Opinion in Cell Biology, v.
36, n. 1, 2015.
RIDLEY, A. J. et al. Cell Migration: Integrating Signals from Front to Back. Science, v. 302,
n. 5651, 2003.
RIDLEY, A. J.; HALL, A. Distinct patterns of actin organization regulated by the small GTPbinding proteins Rac and Rho. In: Cold Spring Harbor symposia on quantitative biology. Cold
Spring Harbor Laboratory Press, 1992. p. 661-671.
RITTER, Uwe et al. CD8α‐and Langerin‐negative dendritic cells, but not Langerhans cells, act
as principal antigen‐presenting cells in leishmaniasis. European journal of immunology, v.
34, n. 6, p. 1542-1550, 2004.
ROCHA, M. I. et al. Leishmania infantum Enhances Migration of Macrophages via a
Phosphoinositide 3-Kinase γ-Dependent Pathway. ACS Infectious Diseases, v. 6, n. 7, 2020.
RODRÍGUEZ-GONZÁLEZ, Jorge; WILKINS-RODRÍGUEZ, Arturo A.; GUTIÉRREZKOBEH, Laila. Human Dendritic Cell Maturation Is Modulated by Leishmania mexicana
through Akt Signaling Pathway. Tropical Medicine and Infectious Disease, v. 9, n. 5, p. 118,
2024.
ROGERS, et al. Type 1 and type 2 responses to Leishmania major. Microbiology Letters, v.
209, n. 1, p. 1-7, 2002
ROGERS, M. E.; CHANCE, M. L.; BATES, P. A. The role of promastigote secretory gel in
the origin and transmission of the infective stage of Leishmania mexicana by the sandfly
Lutzomyia longipalpis. Parasitology, v. 124, n. 5, p. 495-507, 2002.
ROMER, L. H.; BIRUKOV, K. G.; GARCIA, J. G. N. Focal adhesions: Paradigm for a
signaling nexus. Circulation Research, vol. 98, no. 5, p. 606–616, 2006.
SACKS, D. L.; PERKINS, P. V. Development of infective stage Leishmania promastigotes
within phlebotomine sand flies. The American Journal of Tropical Medicine and Hygiene,
v. 34, n. 3, p. 456-459, 1985.
80
SACKS, David L. et al. Developmental modification of the lipophosphoglycan from
Leishmania major promastigotes during metacyclogenesis. Molecular and biochemical
parasitology, v. 42, n. 2, p. 225-233, 1990.
SACKS, David L. et al. Stage-specific binding of Leishmania donovani to the sand fly vector
midgut is regulated by conformational changes in the abundant surface lipophosphoglycan. The
Journal of Experimental Medicine, v. 181, n. 2, p. 685-697, 1995.
SÁNCHEZ-BARINAS, Christian David et al. Mycobacterium tuberculosis H37Rv LpqG
protein peptides can inhibit mycobacterial entry through specific interactions. Molecules, v. 23,
n. 3, p. 526, 2018.
SANDER, E. E.; TEN KLOOSTER, J. P.; VAN DELFT, S.; VAN DER KAMMEN, R. A.;
COLLARD, J. G. Rac downregulates Rho activity: Reciprocal balance between both GTPases
determines cellular morphology and migratory behavior. Journal of Cell Biology, vol. 147, no.
5, p. 1009–1021, 1999.
SCHLEICHER, Ulrike et al. NK cell activation in visceral leishmaniasis requires TLR9,
myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. The Journal of
Experimental Medicine, v. 204, n. 4, p. 893-906, 2007.
SILACCI, P.; MAZZOLAI, L.; GAUCI, C.; STERGIOPULOS, N.; YIN, H. L.; HAYOZ, D.
Gelsolin superfamily proteins: Key regulators of cellular functions. Cellular and Molecular Life
Sciences, vol. 61, no. 19–20, p. 2614–2623, Oct. 2004.
SINGARAVELU, Pavithra et al. Yersinia effector protein (YopO)-mediated phosphorylation
of host gelsolin causes calcium-independent activation leading to disruption of actin
dynamics. Journal of Biological Chemistry, v. 292, n. 19, p. 8092-8100, 2017.
SOUSA, Caetano Reis; SHER, Alan; KAYE, Paul. The role of dendritic cells in the induction
and regulation of immunity to microbial infection. Current Opinion in Immunology, v. 11,
n. 4, p. 392-399, 1999.
SPATH, Gerald F. et al. Persistence without pathology in phosphoglycan-deficient Leishmania
major. Science, v. 301, n. 5637, p. 1241-1243, 2003b.
SPÄTH, Gerald F. et al. The role (s) of lipophosphoglycan (LPG) in the establishment of
Leishmania major infections in mammalian hosts. Proceedings of the National Academy of
Sciences, v. 100, n. 16, p. 9536-9541, 2003a.
SPIERING, D.; HODGSON, L. Dynamics of the rho-family small GTPases in actin regulation
and motility. Cell Adhesion and Migration, vol. 5, no. 2, p. 170–180, 2011.
STANLEY, Amanda C. et al. VCAM-1 and VLA-4 modulate dendritic cell IL-12p40
production in experimental visceral leishmaniasis. PLoS Pathogens, v. 4, n. 9, p. e1000158,
2008.
SUNDQUIST, Malin; RYDSTRÖM, Anna; WICK, Mary Jo. Immunity to Salmonella from a
dendritic point of view. Cellular microbiology, v. 6, n. 1, p. 1-11, 2004.
81
TAN, Jonathan KH; O'NEILL, Helen C. Maturation requirements for dendritic cells in T cell
stimulation leading to tolerance versus immunity. Journal of Leukocyte Biology, v. 78, n. 2,
p. 319-324, 2005.
TARONE, G. et al. Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete
protrusions of the ventral membrane called podosomes, Exp. Cell Res, v.159, n.1, p. 141–157,
1985.
TREPAT, X.; CHEN, Z.; JACABSON, K. Cell migration. Comprehensive Physiology, v. 2,
n. 4, 2012.
TROMBETTA, E. Sergio et al. Activation of lysosomal function during dendritic cell
maturation. Science, v. 299, n. 5611, p. 1400-1403, 2003.
TURCO, Salvatore J.; DESCOTEAUX, Albert. The lipophosphoglycan of Leishmania
parasites. Annual Review of Microbiology, v. 46, n. 1, p. 65-92, 1992.
TURCO, Salvatore J.; SPÄTH, Gerald F.; BEVERLEY, Stephen M. Is lipophosphoglycan a
virulence factor? A surprising diversity between Leishmania species. Trends in parasitology,
v. 17, n. 5, p. 223-226, 2001.
TURNER, C. E. Paxillin and focal adhesion signalling. Nature Cell Biology, vol. 2, no. 12,
2000.
VAN GRIENSVEN, J. et al. Leishmaniasis in immunosuppressed individuals. Clinical
Microbiology and Infection, v. 20, n. 4, p. 286-299, 2014.
VAN GRIENSVEN, J; DIRO, Ermias. Visceral leishmaniasis. Infectious Disease Clinics, v.
26, n. 2, p. 309-322, 2012.
VARGAS-INCHAUSTEGUI, Diego A. et al. Distinct roles for MyD88 and Toll-like receptor
2 during Leishmania braziliensis infection in mice. Infection and Immunity, v. 77, n. 7, p.
2948-2956, 2009.
VERAS, P.; BEZERRA DE MENEZES, J. Using Proteomics to Understand How Leishmania
Parasites Survive inside the Host and Establish Infection. International Journal of Molecular
Sciences, vol. 17, no. 8, p. 1270, 19 Aug. 2016.
VINET, Adrien F. et al. The Leishmania donovani lipophosphoglycan excludes the vesicular
proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V. PLoS
pathogens, v. 5, n. 10, p. e1000628, 2009.
VON STEBUT, Esther et al. Uptake of Leishmania major amastigotes results in activation and
interleukin 12 release from murine skin–derived dendritic cells: implications for the initiation
of anti-Leishmania immunity. The Journal of Experimental Medicine, v. 188, n. 8, p. 1547-
1552, 1998.
WEBER, Kathrin et al. The circle of life: Phases of podosome formation, turnover and
reemergence. European journal of cell biology, v. 101, n. 2, p. 151218, 2022.
82
WEINKOPFF, Tiffany et al. Role of Toll-like receptor 9 signaling in experimental Leishmania
braziliensis infection. Infection and Immunity, v. 81, n. 5, p. 1575-1584, 2013.
WENZEL, Ulf Alexander et al. Leishmania major parasite stage‐dependent host cell invasion
and immune evasion. The FASEB Journal, v. 26, n. 1, p. 29-39, 2012.
WHEELER, Ann P. et al. Rac1 and Rac2 regulate macrophage morphology but are not essential
for migration. Journal of cell science, v. 119, n. 13, p. 2749-2757, 2006.
WHO. Control of the leishmaniases. Geneva: World Health Organization, 2010.
WOZNIAK, M. A.; MODZELEWSKA, K.; KWONG, L.; KEELY, P. J. Focal adhesion
regulation of cell behavior. Biochimica et Biophysica Acta - Molecular Cell Research, vol.
1692, no. 2–3, p. 103–119, 2004.
ZAMIR, E.; GEIGER, B. Components of cell-matrix adhesions. Journal of Cell Science, vol.
114, no. 20, 2001.
ZHAN, Yifan et al. Resident and monocyte-derived dendritic cells become dominant IL-12
producers under different conditions and signaling pathways. The Journal of Immunology, v.
185, n. 4, p. 2125-2133, 2010.
ZHAO, Y. et al. The MAPK signaling pathways as a novel way in regulation and treatment of
parasitic diseases. Diseases, v. 7, n. 1, p. 9, 2019.
ZIJLSTRA, E. E. et al. Kala-azar in displaced people from southern Sudan: epidemiological,
clinical and therapeutic findings. Transactions of the Royal Society of Tropical Medicine
and Hygiene, v. 85, n. 3, p. 365–369, 1991.
ZORGATI, H. et al. The role of gelsolin domain 3 in familial amyloidosis (Finnish type).
Proceedings of the National Academy of Sciences,v. 116, n. 28, 2019. | pt_BR |
