| dc.relation.references | 1. Abbas, A.K.; Lichtman, A.H.; Pillai, S. Imunologia Celular e Molecular. 9ᵃ
Edição. Elsevier, 2019.
2. Agência Nacional de Vigilância Sanitária – ANVISA.
https://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2022/acesse-as-bulasdas-vacinas-contra-a-covid-19.
3. Agrawal A, Agrawal S, Gupta S. Dendritic cells in human aging. Exp Gerontol.
2007;42:421–6.
4. Agrawal A, Agrawal S, Tay J, Gupta S. Biology of dendritic cells in aging. J Clin
Immunol. 2008;28:14–20.
5. Aggarwa A, Shrivastava A, Kumar A, Ali A. Clinical and epidemiological
features of SARS-CoV-2 patients in SARI ward of a tertiary care centre in New
Delhi. J Assoc Physicians India. 2020;68(7):19–26.
6. Akinbo BD, Atere AD, Fatunade HB, Iyabor NO. Hematological índices and
absolute CD4 counts of an apparently healthy population in Ondo State, Nigeria.
Br J Med Med Res. 2015;8(8):717-23.
7. Akunuru S, Geiger H. Aging, clonality and rejuvenation of hematopoietic stem
cells. Trends Mol Med 2016;22:701–12.
8. Al-Mawali A, Pinto AD, Al Busaidi R, Al-Zakwani I. Lymphocyte subsets:
reference ranges in an age- and gender-balanced population of Omani healthy
adults. Cytometry A. 2013;83(8):739-44.
9. Arientová S, Matúšková K, Bartoš O, Holub M, Beran O. Specific immune
responses after BNT162b2 mRNA vaccination and COVID-19 infection. Front
Immunol [Internet]. 2023 Oct 17 [cited 2023 Dec 6];14:1271353. Available from:
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1271353/full
10. Ansari A, Sachan S, Jit BP, Sharma A, Coshic P, Sette A, et al. An efficient
immunoassay for the B cell help function of SARS-CoV-2-specific memory CD4+
T cells. Cell Rep Methods [Internet]. 2022 Jun [cited 2023 Dec 6];2(6):100224.
Available from: https://linkinghub.elsevier.com/retrieve/pii/S266723752200087X
101
11. Azkur AK, Akdis M, Azkur D, Sokolowska M, Van De Veen W, Brüggen MC,
O'Mahony L, Gao Y, Nadeau K, Akdis CA. Immune response to SARS-CoV-2
and mechanisms of immunopathological changes in COVID-19. Allergy. 2020
Jul;75(7):1564-1581. doi: 10.1111/all.14364. PMID: 32396996; PMCID:
PMC7272948.
12. Bailey LC, Razzaghi H, Burrows EK, Bunnell HT, Camacho PE, Christakis
DA, Forrest CB. Assessment of pediatric patients tested for severe acute
respiratory syndrome coronavirus 2 across the United States. JAMA Pediatr.
2021;175(2):176–84.
13. Bakhiet M, Taurin S. SARS-CoV-2: Targeted managements and vaccine
development. Cytokine Growth Factor Rev. 2021 Apr;58:16-29. doi:
10.1016/j.cytogfr.2020.11.001. Epub 2020 Dec 1. PMID: 33293238; PMCID:
PMC7706592.
14. Barbosa, M.D.S.; Croda, M.G.; Simionatto, S. Vaccination against COVID-19
in the Brazilian indigenous population: Has science been defeated by fake news?
Rev. Soc. Bras. Med. Trop. 2021, 54, e0272-2021.
15. Benites E, Gisloti LJ, De Oliveira Roque F. Brazil: Boost COVID-19 vaccine
uptake in Indigenous people. Nature [Internet]. 2021 Mar 18 [cited 2023 Nov
9];591(7850):369–369. Available from: https://www.nature.com/articles/d41586-
021-00689-6
16. Bernardeau-Serra, L.; Nguyen-Huynh, A.; Sponagel, L.; Sernizon Guimarães,
N.; Teixeira De Aguiar, R.A.; Soriano Marcolino, M. The COVID-19 Vaccination
Strategy in Brazil—A Case Study. Epidemiologia 2021, 2, 338–359.
17. Blair SN. Physical inactivity: The biggest public health problem of the 21st
century. Br J Sports Med. 2009;43(1):1–2.
18. Booth FW, Roberts CK, Thyfault JP, Ruegsegger GN, Toedebusch RG. Role
of inactivity in chronic diseases: Evolutionary insight and pathophysiological
mechanisms. Physiol Rev. 2017;97(4):1351–402.
102
19. Bohner P, Chevalier MF, Cesson V, Rodrigues-Dias SC, Dartiguenave F,
Burruni R, et al. Double Positive CD4+CD8+ T Cells Are Enriched in Urological
Cancers and Favor T Helper-2 Polarization. Front Immunol. 2019;10:622.
20. Bolsewicz KT, Steffens MS, Bullivant B, King C, Beard F. “To Protect Myself,
My Friends, Family, Workmates and Patients …and to Play My Part”: COVID-19
Vaccination Perceptions among Health and Aged Care Workers in New South
Wales, Australia. Int J Environ Res Public Health [Internet]. 2021 Aug 25 [cited
2023 Dec 12];18(17):8954. Available from: https://www.mdpi.com/1660-
4601/18/17/8954
21. Brazil. Brasil. Censo Demográfico 2022: Indígenas - Primeiros resultados do
Universo. Brasil: IBGE 2022.
22. Brasil. Ministério da Saúde. Secretaria de Atenção Especializada `a Saúde.
Departamento de Atenção Hospitalar, Domiciliar e de Urgência. Protocolo de
manejo clínico da Covid-19 na Atenção Especializada [recurso eletrônico]/
Ministério da Saúde, Secretaria de Atenção Especializada `a Saúde,
Departamento de Atenção Hospitalar, Domiciliar e de Urgência. – 1. ed. rev. –
Brasília: Ministério da Saúde, 2020. 48 p. : il. Nota: 1a edição revisada da obra
Protocolo de Manejo Clínico para o Novo Coronavírus (2019-nCoV). Modo de
acesso: World Wide Web:
https://bvsms.saude.gov.br/bvs/publicacoes/manejo_clinico_covid-19_atencao_
especializada.pdf. ISBN 978-85-334-2766-2’. [Online]. Available: https://bvsms.
saude.gov.br/bvs/publicacoes/manejo_clinico_covid19_atencao_especializada.
pdf.
23. British Dietetic Association. BDA critical care specialist group COVID-19 best
practice guidance: Feeding patients on critical care units in the prone position
(awake and dated). London: BDA; 2020.Available from: https://www.
bda.uk.com/resource/best-practice-guidance-enteral-feed-ing-in-prone
position.html.
24. Bronchoalveolar lavage constituents in healthy individuals, idiopathic
pulmonary fibrosis, and selected comparison groups. The BAL Cooperative
103
Group Steering Committee. Am Rev Respir Dis. 1990;141(5 Pt 2):S169-
202.Review.
25. Brümmer, L.E.; Katzenschlager, S.; Gaeddert, M.; Erdmann, C.; Schmitz, S.;
Bota, M.; Grilli, M.; Larmann, J.; Weigand, M.A.; Pollock, N.R.; et al. Accuracy of
novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and
meta-analysis. PLoS Med. 2021, 18, e1003735.
26. Burke WM, Roberts CM, Bryant DH, Cairns D, Yeates M, Morgan GW, et al.
Smoking-induced changes in epithelial lining fluid volume, cell density and
protein. Eur Respir J. 1992;5(7):780-4.
27. Busà R, Sorrentino MC, Russelli G, Amico G, Miceli V, Miele M, et al. Specific
Anti-SARS-CoV-2 Humoral and Cellular Immune Responses After Booster Dose
of BNT162b2 Pfizer-BioNTech mRNA-Based Vaccine: Integrated Study of
Adaptive Immune System Components. Front Immunol [Internet]. 2022 Mar 24
[cited 2023 Dec 6];13:856657. Available from:
https://www.frontiersin.org/articles/10.3389/fimmu.2022.856657/full
28. B. Cao, D. Zhang, C. Wang, A trial of Lopinavir-Ritonavir in Covid-19. Reply,
N. Engl. J. Med. 382 (21) (2020) e68. Channappanavar R, Fehr AR, Zheng J,
Wohlford-Lenane C, Abrahante JE, Mack M, Perlman S. IFN-I response timing
relative to virus replication determines MERS coronavirus infection outcomes. J
Clin Invest. 2019;129(9):3625–39.
29. Cevik M, Kuppalli K, Kindrachuk J, Peiris M. Virology, transmission, and
pathogenesis of SARS-CoV-2. BMJ. 2020 Oct 23;371:m3862. doi:
10.1136/bmj.m3862. PMID: 33097561.
30. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei
Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of
99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive
study. Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-
6736(20)30211-7. Epub 2020 Jan 30. PMID: 32007143; PMCID: PMC7135076.
104
31. Chen, N, et al. Epidemiological and clinical characteristics of 99 cases of 2019
novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet 395
(10223) (2020) 507–513.
32. Chen L, Liu HG, Liu W, Liu J, Liu K, Shang J, Wei S. Analysis of clinical
features of 29 patients with 2019 novel coronavirus pneumonia. Zhonghua Jie He
He Hu Xi Za Zhi. 2020;43(0): E005 (in Chinese).
33. Chen, S.; Guan, F.; Candotti, F.; Benlagha, K.; Camara, N.O.S.; Herrada,
A.A.; James, L.K.; Lei, J.; Miller, H.; Kubo, M.; et al. The role of B cells in COVID19 infection and vaccination. Front. Immunol. 2022, 13, 988536.
33. Cheung CY, Poon LL, Ng IH, LukW, Sia SF,Wu MH, Peiris JS. Cytokine
responses in severe acute respiratory syndrome coronavirus-infected
macrophages in vitro: Possible relevance to pathogenesis. J Virol.
2005;79(12):7819–26.
34. Chowdhury, M.A.; Hossain, N.; Kashem, M.A.; Shahid, M.A.; Alam, A.
Immune response in COVID-19: A review. J. Infect. Public Health 2020, 13,
1619–1629.
35. Chng WJ, Tan GB, Kuperan P. Establishment of adult peripheral blood
lymphocyte subset reference range for an Asian population by single-platform
flow cytometry: influence of age, sex, and race and comparison with other
published studies. Clin Diagn Lab Immunol. 2004;11(1):168-73.
36. Ciabattini A, Nardini C, Santoro F, Garagnani P, Franceschi C, Medaglini D.
Vaccination in the elderly: The challenge of immune changes with aging. Semin
Immunol. 2018;40:83–94.
37. Cleemput S, Dumon W, Fonseca V, Abdool Karim W, Giovanetti M, Alcantara
LC, De Oliveira T. Genome detective coronavirus typing tool for rapid
identification and characterization of novel coronavirus genomes. Bioinformatics.
2020;36(11):3552–5.
38. Codd, Amy et al. Neutrophilia, lymphopenia and myeloid dysfunction: a living
review of the quantitative changes to innate and adaptive immune cells which
define COVID-19 pathology. Oxf Open Immunol. v. 2, n. 1. 2021.
105
39. Cohen CA, Li APY, Hachim A, Hui DSC, Kwan MYW, Tsang OTY, et al.
SARS-CoV-2 specific T cell responses are lower in children and increase with
age and time after infection. Nat Commun [Internet]. 2021 Jul 29 [cited 2024 Mar
7];12(1):4678. Available from: https://www.nature.com/articles/s41467-021-
24938-4
40. Collie S, Champion J, Moultrie H, Bekker LG, Gray G. Effectiveness of
BNT162b2 Vaccine against Omicron Variant in South Africa. N Engl J Med
[Internet]. 2022 Feb 3 [cited 2024 Mar 7];386(5):494–6. Available from:
http://www.nejm.org/doi/10.1056/NEJMc2119270
41. Cook, I.F. Best vaccination practice and medically attended injection site
events following deltoid intramuscular injection. Hum. Vaccines Immunother.
2015, 11, 1184–1191.
42. Costa, P.R.; Correia, C.A.; Marmorato, M.P.; Dias, J.Z.D.C.; Thomazella,
M.V.; Da Silva, A.C.; Oliveira, A.C.S.D.; Gusmão, A.F.; Ferrari, L.; Freitas, A.C.;
et al. Humoral and cellular immune responses to CoronaVac assessed up to one
year after vaccination. MedRxiv 2022.
43. Costabel U, Guzman J. Effect of smoking on bronchoalveolar lavage
constituents. Eur Respir J. 1992;5(7):776-9.
44. Costabel U, Bross KJ, Reuter C, Rühle KH, Matthys H. Alterations in
immunoregulatory T-cell subsets in cigarette smokers. A phenotypic analysis of
bronchoalveolar and blood lymphocytes. Chest. 1986;90(1):39-44.
45. Crotty S. A Brief History of T Cell Help to B Cells. Nat Rev Immunol
(2015)15:185. doi: 10.1038/NRI3803
46. Croda, J.; Oliveira, W.K.d.; Frutuoso, R.L.; Mandetta, L.H.; Baia-da-Silva,
D.C.; Brito-Sousa, J.D.; Monteiro, W.M.; Lacerda, M.V.G. COVID-19 in Brazil:
Advantages of a socialized unified health system and preparation to contain
cases. Rev. Soc. Bras. Med. Trop. 2020, 53, e20200167.
47. Cumbane V, Imbach M, Chissumba RM, Macicame I, Eller LA, Lawlor J, et
al. Determining hematological, biochemical and immunological reference values
106
in healthy adults with high-risk for HIV acquisition in Mozambique. PLoS One.
2020;15(4):e0232018.
48. Davidson S, Maini MK, Wack A. Disease-promoting effects of type I
interferons in viral, bacterial and coinfections. J Interf Cytokine Res.
2015;35(4):252–64.
49. De Faria, E.; Guedes, A.R.; Oliveira, M.S.; De Godoy Moreira, M.V.; Maia,
F.L.; Dos Santos Barboza, A.; Leme, M.D.; Letaif, L.S.H.; Miethke-Morais, A.;
Bonfá, E.; et al. Performance of vaccination with CoronaVac in a cohort of
healthcare workers (HCW)—Preliminary report. MedRxiv 2021.
50. De la Fuente M, Miquel J. An update of the oxidation-in-flammation theory of
aging: The Involvement of the immune system in oxiinflammaging. Curr Pharm
Des. 2009;15:3003–26.
51. De Oliveira E, Macedo LFR, De Beltrão ICSL, Dos Santos NAT, Fernandes
MNM, Neto MLR. Impact of COVID-19 and its variants on indigenous Brazilian
children. J Pediatr Nurs [Internet]. 2022 May [cited 2024 Mar 1];64:178–9.
Available from: https://linkinghub.elsevier.com/retrieve/pii/S0882596322000161
52. De Oliveira LA, De Morais IRB, Barbosa MDS, Beutinger Marchioro S, Leite
Machado LOC, Ferreira Marques M, et al. Immune Response to an Inactivated
Vaccine of SARS-CoV-2 (CoronaVac) in an Indigenous Brazilian Population: A
Cohort Study. Vaccines [Internet]. 2024 Apr 10 [cited 2024 May 17];12(4):402.
Available from: https://www.mdpi.com/2076-393X/12/4/402
53. Diamond MS, Kanneganti TD. Innate immunity: the first line of defense
against SARS-CoV-2. Nat Immunol. 2022 Feb;23(2):165-176. doi:
10.1038/s41590-021-01091-0. Epub 2022 Feb 1. PMID: 35105981; PMCID:
PMC8935980.
54. Doremalen, N. Van et al.ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2
pneumonia in rhesus macaques, Nature 586 (7830) (2020) 578–582.
55. Drent M, Mansour K, Linssen C. Bronchoalveolar lavage in sarcoidosis.
Semin Respir Crit Care Med. 2007;28(5):486-95.
107
56. Drosten C., Gunther S, Preister W, Van Der Werf S. et. al. Identification of a
novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J.
Med. 2003. 348:1967–1976.
57. Du L, Tai W, Yang Y, Zhao G, Zhu Q, Sun S, Liu C, Tao X, Tseng CK, Perlman
S, Jiang S, Zhou Y, Li F. Introduction of neutralizing immunogenicity index to the
rational design of MERS coronavirus subunit vaccines. Nat Commun. 2016 Nov
22; 7:13473. doi: 10.1038/ncomms13473. PMID: 27874853; PMCID:
PMC5121417.
58. Dunstan DW, Salmon J, Owen N, Armstrong T, Zimmet PZ, Welborn TA,
Shaw JE. Associations of TV viewing and physical activity with the metabolic
syndrome in Australian adults. Diabetologia. 2005;48(11):2254–61.
59. Farhadi S, Ovchinnikov RS. The relationship between nutrition and infectious
diseases: A review. Biomed Biotechnol Res J. 2018;8 (3):168–72.
60. Feng Z, Diao B, Wang R, Wang G, Wang C, Tan Y, Liu L, Wang C, Liu Y, Liu
Y, Yuan Z, Ren L, Wu Y, Chen Y. The novel severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) directly decimates human spleens and lymph
nodes [Preprint]. Available from:
https://www.medrxiv.org/content/10.1101/2020.03.27.20045427v1.
61. Formisano E, Di Maio P, Ivaldi C, Sferrazzo E, Arieta L, Bongiovanni S,
Demontis S. Nutritional therapy for patients with coronavirus disease 2019
(COVID-19): Practical protocol from a single center highly affected by an outbreak
of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection. Nutrition. 2021;82:111048.
62. Gallichotte, E.N.; Nehring, M.; Stromberg, S.; Young, M.C.; Snell, A.; Daniels,
J.; Pabilonia, K.L.; VandeWoude, S.; Ehrhart, N.; Ebel, G.D. Impact of Prior
Infection on SARS-CoV-2 Antibody Responses in Vaccinated Long-Term Care
Facility Staff. Sphere 2022, 7, e00169-22.
63. Gálvez, N.M.; Pacheco, G.A.; Schultz, B.M.; Melo-González, F.; Soto, J.A.;
Duarte, L.F.; González, L.A.; Rivera-Pérez, D.; Ríos, M.; Berrios, R.V.; et al.
Differences in the immune response elicited by two immunization schedules with
108
an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial. eLife
2022, 11, e81477.
64. García-Arriaza, J.; Garaigorta, U.; Pérez, P.; Lázaro-Frías, A.; Zamora, C.;
Gastaminza, P.; Del Fresno, C.; Casasnovas, J.M.; S. Sorzano, C.Ó.; Sancho,
D.; et al. COVID-19 Vaccine Candidates Based on Modified Vaccinia Virus
Ankara Expressing the SARS-CoV-2 Spike Protein Induce Robust T- and B-Cell
Immune Responses and Full Efficacy in Mice. J. Virol. 2021, 95, e02260-20.
65. García-Sastre A, Biron CA. Type 1 interferons and the virus-host relationship:
A lesson in détente. Science. 2006;12;312(5775):879–82.
66. George MR. Hemophagocytic lymphohistiocytosis: Review of etiologies and
management. J Blood Med. 2014;5:69–86.
67. Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory
syndrome-related coronavirus: the species and its viruses - a statement of the
Coronavirus Study Group. bioRxiv 2020; published online Feb 11.
DOI:10.1101/2020.02.07.937862.
68. Gordon S, Martinez FO. Alternative activation of macrophages: mechanism
and functions. Immunity, v. 32, n. 5, p. 593-604, May 2010. ISSN 1097-4180.
69. Grasselli G, ZangrilloA, ZanellaA. Baseline characteristics and outcomes of
1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy
Region, Italy. JAMA. 2020;323(16):1574–81.
70. Grifoni A, Weiskopf D, Ramirez SI, Mateus J, Dan JM, Moderbacher CR,
Sette A. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with
COVID-19 disease and unexposed individuals. Cell. 2020;181(7):1489–501.
71. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Zhong NS. Clinical
characteristics of coronavirus disease 2019 in China. N Eng J Med.
2020;382(18):1708–20.
72. Guaraldi G, Zona S, Silva AR, Menozzi M, Dolci G, Milic J, et al. The dynamic
association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV.
PLoS One. 2019;14(2):e0212283.
109
73. Guo, L.; Wang, G.; Wang, Y.; Zhang, Q.; Ren, L.; Gu, X.; Huang, T.; Zhong,
J.; Wang, Y.; Wang, X.; et al. SARS-CoV-2-specific antibody and T-cell
responses 1 year after infection in people recovered from COVID-19: A
longitudinal cohort study. Lancet Microbe 2022, 3, e348–e356.
74. Hadj Hassine I. Covid-19 vaccines and variants of concern: A review. Rev
Med Virol. 2022 Jul;32(4):e2313. doi: 10.1002/rmv.2313. Epub 2021 Nov 9.
PMID: 34755408; PMCID: PMC8646685.
75. Handu D, Moloney L, Rozga M, Cheng FW. Malnutrition care during the
COVID-19 pandemic: Considerations for registered dietitian nutritionists. J Acad
Nutr Diet. 2021;121(5):979–87.
76. Hallal PC, Hartwig FP, Horta BL, Silveira MF, Struchiner CJ, Vidaletti LP, et
al. SARS-CoV-2 antibody prevalence in Brazil: results from two successive
nationwide serological household surveys. Lancet Glob Health. 2020
Nov;8(11):e1390–8.
77. Hansen CB, Jarlhelt I, Pérez-Alós L, Hummelshøj Landsy L, Loftager M,
Rosbjerg A, et al. SARS-CoV-2 Antibody Responses Are Correlated to Disease
Severity in COVID-19 Convalescent Individuals. J Immunol (2021) 206:109–17.
doi: 10.4049/JIMMUNOL.2000898
78. Hartenian E, Nandakumar D, Lari A, Ly M, Tucker JM, Glaunsinger BA. The
molecular virology of coronaviruses. J Biol Chem. 2020 Sep 11;295(37):12910-
12934. doi: 10.1074/jbc.REV 120.013930. Epub 2020 Jul 13. PMID: 32661197;
PMCID: PMC7489918.
79. He R, Lu Z, Zhang L, Fan T, Xiong R, Shen X, Geng Q. The clinical course
and its correlated immune status in COVID-19 pneumonia. J Clin Virol.
2020;127:104361.
80. Heald-Sargent T, Muller WJ, Zheng X, Rippe J, Patel AB, Kociolek LK. Agerelated differences in nasopharyngeal severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) levels in patients with mild to moderate coronavirus
disease 2019 (COVID-19). JAMA Pediatr. 2020;174(9):902–3.
110
81. Hearps AC, Martin GE, Angelovich TA, Cheng WJ, Maisa A, Landay AL,
Crowe SM. Aging is associated with chronic innate immune activation and
dysregulation of monocyte phenotype and function. Aging Cell. 2012;11(5):867–
75.
82. Heron M, Slieker WA, Zanen P, van Lochem EG, Hooijkaas H, van den Bosch
JM, et al. Evaluation of CD103 as a cellular marker for the diagnosis of pulmonary
sarcoidosis. Clin Immunol. 2008;126(3):338-44.
83. Hitchings, M.D.T.; Ranzani, O.T.; Torres, M.S.S.; De Oliveira, S.B.; Almiron,
M.; Said, R.; Borg, R.; Schulz, W.L.; De Oliveira, R.D.; Da Silva, P.V.; et al.
Effectiveness of CoronaVac among healthcare workers in the setting of high
SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative
case-control study. Lancet Reg. Health-Am. 2021, 1, 100025.
84. Hoffmann M, Kleine-Weber H, Schroeder, Krüger N, Herrler T, Erichsen S,
Pöhlmann S. SARS-CoV-2 cell entry depends onACE2 and TMPRSS2 and is
blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–80.
85. Hu, Jianhua & Wang, Yanggan. The Clinical Characteristics and Risk Factors
of Severe COVID-19. Gerontology. v. 67, n. 3, p. 255-266. 2021.
86. Hu, Ben; Guo, Hua; Zhou, Peng; Shi, Zheng-Li. Characteristics of SARSCoV-2 and COVID-19. Nat Rev Microbiol. v. 19, n. 3, p. 141-154, 2021.
87. Huang, C et al. Clinical features of patients infected with 2019 novel
coronavirus in Wuhan, China, Lancet 395 (10223) (2020) 497–506.
88. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X,
Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H,
Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features
of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020
Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020
Jan 24. Erratum in: Lancet. 2020 Jan 30; : PMID: 31986264; PMCID:
PMC7159299.
111
89. Huang C, WangY, Li X, Ren L, Zhao J, HuY, Cao B. Clinical features of
patients infected with 2019 novel coronavirus inWuhan, China. Lancet.
2020;395(10223):497–506.
90. Hurme A, Jalkanen P, Heroum J, Liedes O, Vara S, Melin M, et al. LongLasting T Cell Responses in BNT162b2 COVID-19 mRNA Vaccinees and
COVID-19 Convalescent Patients. Front Immunol [Internet]. 2022 Apr 22 [cited
2023 Dec 6];13:869990. Available from:
https://www.frontiersin.org/articles/10.3389/fimmu.2022.869990/full
91. Instituto Brasileiro de Geografia e Estatıstica (IBGE). Os indıgenas no Censo
Demografico 2010: primeiras considerações com base no quesito cor ou raça.
Rio de Janeiro: IBGE; 2012. 31 pp.
92. Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nat Rev
Immunol. 2014;14(1):36–49.
93. Janeway CA, Jr Travers P, Walport M, Schlomchik MJ. Immunobiology: The
immune system in health and disease. 5th ed. New York: Garland Science; 2001.
Available from: https://www.ncbi.nlm.nih.gov/books/NBK10757/.
94. Jentsch-Ullrich K, Koenigsmann M, Mohren M, Franke A. Lymphocyte
subsets’ reference ranges in an age- and gender-balanced population of 100
healthy adults-a monocentric German study. Clin Immunol. 2005;116(2):192-7.
95. Jiang Y, Xu J, Zhou C, Wu Z, Zhong S, Liu J, Deng P. Characterization of
cytokine/chemokine profiles of severe acute respiratory syndrome. Am J Respir
Crit Care Med. 2005;171(8):850–7.
96. Jiang W, Kang L, Lu HZ, Pan X, Lin Q, Pan Q, et al. Normal values for CD4
and CD8 lymphocyte subsets in healthy Chinese adults from Shanghai. Clin
Diagn Lab Immunol. 2004;11(4):811-3.
97. Jiang, C.; Chen, Q.; Xie, M. Smoking increases the risk of infectious diseases:
A narrative review. Tob. Induc. Dis. 2020, 18, 60.
112
98. Jiang W, Kang L, Lu HZ, Pan X, Lin Q, Pan Q, et al. Normal values for CD4
and CD8 lymphocyte subsets in healthy Chinese adults from Shanghai. Clin
Diagn Lab Immunol. 2004;11(4):811-3.
99. Jiang, C.; Chen, Q.; Xie, M. Smoking increases the risk of infectious diseases:
A narrative review. Tob. Induc. Dis. 2020, 18, 60.
100. Jonjić S, Babić M, Polić B, Krmpotić A. Immune Evasion of Natural Killer
Cells by Viruses. Curr Opin Immunol (2008) 20:30–8. doi: 10.1016/
J.COI.2007.11.002
101. Karacin, C.; Eren, T.; Zeynelgil, E.; Imamoglu, G.I.; Altinbas, M.; Karadag,
I.; Basal, F.B.; Bilgetekin, I.; Sutcuoglu, O.; Yazici, O.et al. Immunogenicity and
safety of the CoronaVac vaccine in patients with cancer receiving active systemic
therapy. Future Oncol. 2021, 17, 4447–4456.
102. Kellam P, Barclay W. The dynamics of humoral immune responses following
SARS-CoV-2 infection and the potential for reinfection. J Gen Virol.
2020;101(8):791.
103. Khatib R, Glowacki N, Lauffenburger J, Siddiqi A. Race/ethnic differences in
atherosclerotic cardiovascular disease risk factors among patients with
hypertension: analysis from 143 primary care clinics. Am J Hypertens. 2021;
34(9):948-55.
104. Kim ES, Choe PG, Park WB, Oh HS, Kim EJ, Nam EY, Oh MD. Clinical
progression and cytokine profiles of Middle East respiratory syndrome
coronavirus infection. J Korean Med Sci. 2016;31(11):1717–25.
105. Kolopp-Sarda MN, Kohler C, De March AK, Béné MC, Faure G.
Discriminative immunophenotype of bronchoalveolar lavage CD4 lymphocytes in
sarcoidosis. Lab Invest. 2000;80(7):1065-9.
106. KSIAZEK TG, ERDMAN D, GOLDSMITH CS, et al. and the SARS Working
Group. A novel coronavirus associated with severe acute respiratory syndrome.
2003. N. Engl. J. Med. 348:1953–1966.
113
107. Kuller LH. Ethnic differences in atherosclerosis, cardiovascular disease and
lipid metabolism. Curr Opin Lipidol. 2004;15(2):109-13. Review.
108. Langers I, Renoux VM, Thiry M, Delvenne P, Jacobs N. Natural killer cells:
role in local tumor growth and metastasis. Biologics. 2012;6:73-82. doi:
10.2147/BTT.S23976. Epub 2012 Apr 5. PMID: 22532775; PMCID:
PMC3333822.
109. Langmore SE, Terpenning MS, Schork A, Chen Y, Murray JT, Lopatin D,
Loesche WJ. Predictors of aspiration pneumonia: How important is dysphagia?
Dysphagia. 1998;13(2):69–81.
110. Lau SK, Lau CC, Chan KH, Li CP, Chen H, Jin DY, Yuen, KY. Delayed
induction of proinflammatory cytokines and suppression of innate antiviral
response by the novel Middle East respiratory syndrome coronavirus:
Implications for pathogenesis and treatment. J Gen Virol. 2013;94(12):2679–90.
111. Law HK, Cheung CY, Ng HY, Sia SF, Chan YO, Luk W, Lau YL. Chemokine
up-regulation in SARS-coronavirus infected, monocyte-derived human dendritic
cells. Blood. 2005;106(7):2366–74.
112. Lee S, Kim T, Lee E, Lee C, Kim H, Rhee H, Kim TH. Clinical course and
molecular viral shedding among asymptomatic and symptomatic patients with
SARS-CoV-2 infection in a community treatment center in the Republic of Korea.
JAMA Intern Med. 2020;180(11):1447–52.
113. Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, Wu J. Coronavirus infections and
immune responses. J Med Virol. 2020;92(4):424–32.
114. Lima FR, Croda MG, Muniz DA, Gomes IT, Soares KR, Cardoso MR, et al.
Evaluation of the traditional and revised World Health Organization classifications
of dengue cases in Brazil. Clinics (São Paulo). 2013;68(10): 1299-304.
115. Lopera TJ, Chvatal-Medina M, Flórez-Álvarez L, Zapata-Cardona MI,
Taborda NA, Rugeles MT, Hernandez JC. Humoral Response to BNT162b2
Vaccine Against SARS-CoV-2 Variants Decays After Six Months. Front Immunol.
2022 May 2; 13:879036. doi: 10.3389/fimmu.2022.879036. PMID: 35585980;
PMCID: PMC9108166.
114
116. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The
hallmarks of aging. Cell. 2013;153(6): 1194–217.
117. LI, YOUJIANG et al. Clinical characteristics, cause analysis and infectivity
of COVID‐19 nucleic acid repositive patients: A literature review. Journalof
Medical Virology, v. 93, n. 3, p. 1288–1295. 2021.
118. Machado, F.C.G.; Ferron, M.M.; Barddal, M.T.D.M.; Nascimento, L.A.;
Rosalen, J.; Avelino-Silva, V.I. COVID-19 vaccination, incidence, and mortality
rates among indigenous populations compared to the general population in
Brazil: Describing trends over time. Lancet Reg. Health-Am. 2022, 13, 100319.
119. Md Khairi, L.N.H.; Fahrni, M.L.; Lazzarino, A.I. The Race for Global
Equitable Access to COVID-19 Vaccines. Vaccines 2022, 10,1306.
120. Majumder J, Minko T. Recent Developments on Therapeutic and Diagnostic
Approaches for COVID-19. AAPS J. 2021 Jan 5;23(1):14. doi: 10.1208/s12248-
020-00532-2. PMID: 33400058; PMCID: PMC7784226.
121. Malik ys, Kumar N, Sircar S, Kaushik R, Bhat S, Dhama K, Gupta P, Goyal
K, Singh MP, Ghoshal U, El Zowalaty Me, Orv, Yatoo Mi, Tiwari R, Pathak M,
Patel SK, Sah R, Rodriguez-Morales AJ, Ganesh B, Kumar P, Singh RK.
Coronavirus Disease Pandemic (COVID-19): Challenges and a Global
Perspective. Pathogens. 2020 Jun 28;9(7):519. doi: 10.3390/pathogens9070519.
PMID: 32605194; PMCID: PMC7400054.
122. Marchingo JM, Sinclair LV, Howden AJM, Cantrell DA. Quantitative analysis
of how Myc controls T cell proteomes and metabolic pathways during T cell
activation. eLife. 2020;5(9):e53725.
123. Martindale R, Patel JJ, Taylor B, Warren M, McClave SA. Nutrition therapy
in the patient with COVID-19 disease requiring ICU care [updated March 30,
2020]. Available from: https://www.sccm.org/getattachment/disaster/NutritionTherapy-COVID-19-SCCM-ASPEN.
124. Maruggi, G., et al. mRNA as a transformative technology for vaccine
development to control infectious diseases, Mol. Ther. 27 (4) (2019) 757–772.
115
125. Medeiros-Ribeiro, A.C.; Aikawa, N.E.; Saad, C.G.S.; Yuki, E.F.N.; Pedrosa,
T.; Fusco, S.R.G.; Rojo, P.T.; Pereira, R.M.R.; Shinjo, S.K.; Andrade, D.C.O.; et
al. Immunogenicity and safety of the CoronaVac inactivated vaccine in patients
with autoimmune rheumatic diseases: A phase 4 trial. Nat. Med. 2021, 27, 1744–
1751.
126. McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B.
Guidelines for the provision and assessment of nutrition support therapy in the
adult critically ill patients: Society of critical care medicine (SCCM) and American
society for parenteral and enteral nutrition (ASPEN). JPEN J Parenter Enteral
Nutr. 2009; 3(3):277–316.
127. McGonagle D, Sharif K, O’Regan A, Bridgewood C. The role of cytokines
including interleukin-6 in COVID-19 induced pneumonia and macrophage
activation syndrome-like disease. Autoimmun Rev. 2020;19(6):102537.
128. McNab F, Mayer-Barber K, Sher A, Wack A, O'Garra A. Type I interferons
in infectious disease. Nat Rev Immunol. 2015 Feb;15(2):87-103. doi:
10.1038/nri3787. PMID: 25614319; PMCID: PMC7162685.
129. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ.
COVID-19: Consider cytokine storm syndromes and immunosuppression.
Lancet. 2020;395(10229):1033–4.
130. Melenottea C, Silvina A, Goubeta AG. Immune responses during COVID-19
infection. Oncoimmunology. 2020;9(1):1807836.
131. Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, Vellas B,
Nourhashemi F. Proinflammatory cytokines, aging, and age-related diseases. J
Am Med Dir Assoc. 2013;14(12):877–82.
133. Min CK, Cheon S, Ha NY, Sohn KM, Kim Y, Aigerim A, Kim YS. Comparative
and kinetic analysis of viral shedding and immunological responses in MERS
patients representing a broad spectrum of disease severity. Sci Rep.
2016;6(1):25359.
116
134. Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, Vellas B,
Nourhashemi F. Proinflammatory cytokines, aging, and age-related diseases. J
Am Med Dir Assoc. 2013;14(12):877–82.
135. Mishra SK, Tripathi T. One year update on the COVID-19 pandemic: Where
are we now? Acta Trop. 2021 Feb; 214:105778. doi:
10.1016/j.actatropica.2020.105778. Epub 2020 Nov 28. PMID: 33253656;
PMCID: PMC7695590.
136. Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. Causes,
consequences and reversal of immune system aging. J Clin Invest.
2013;123:958–65.
137. Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CG, Doering
TA, Artis D. Innate lymphoid cells promote lung-tissue homeostasis after infection
with influenza virus. Nat Immunol. 2011;12(11):1045–54.
138. Narici M, Vito GD, Franchi M, Paoli A, Moro T, Marcolin G, Maganaris C.
Impact of sedentarism due to the COVID-19 home confinement on
neuromuscular, cardiovascular and metabolic health: Physiological and
pathophysiological implications and recommendations for physical and nutritional
countermeasures. Eur J Sport Sci. 2021;21(4):614–35.
139. Neves M, Marinho-Dias J, Ribeiro J, Sousa H. Epstein-Barr virus strains and
variations: geographic or disease-specific variants? J Med Virol. 2017; 89(3):373-
87.
140. News Medical Life Scince. https://www.newsmedical.net/news/20201102/Global-collaboration-provides-a-COVID-19diseasemap.aspx
141. Ng DL, Hosani F, Keating MK, Gerber SI, Jones TL, Metcalfe MG, Zaki SR.
Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal
case of Middle East respiratory syndrome coronavirus infection in the United Arab
Emirates, April 2014. Am J Pathol. 2016;186(3):652–8.
117
142. Ngowi BJ, Mfinanga SG, Bruun JN, Morkve O. Immunohaematological
reference values in human immunodeficiency virus-negative adolescent and
adults in rural northern Tanzania. BMC Infect Dis. 2009;9(1):1.
143. Nikolich-Žugich J. The twilight of immunity: Emerging concepts in aging of
the immune system. Nat Immunol. 2018;19(1):10–9.
144. Nikolich-Zugich J, Knox KS, Rios CT, Natt B, Bhattacharya D, Fain MJ.
SARS-CoV-2 and COVID-19 in older adults: What we may expect regarding
pathogenesis, immune responses, and outcomes. Geroscience.
2020;42(2):505–14.
145. Nuwarda, R.F.; Ramzan, I.; Weekes, L.; Kayser, V. Vaccine Hesitancy:
Contemporary Issues and Historical Background. Vaccines 2022, 10, 1595.
146. Nyugen J, Agrawal S, Gollapudi S, Gupta S. Impaired functions of peripheral
bloodmonocyte subpopulations in aged humans. J Clin Immunol. 2010;30:806–
13.
147. Ong SM, Hadadi E, Dang TM, Yeap WH, Tan CTY, Ng TP,Wong SC. The
pro-inflammatory phenotype of the human non-classical monocyte subset is
attributed to senescence. Cell Death Dis. 2018;9(3):226.
148. Paliot EM. Na mata do sabia: contribuicões sobre a presença indígena no
Ceará. Fortaleza: Secult/ Museu do Ceará/ IMOPEC; 2009. 461 p.
149. Palmer DB. The effect of age on thymic function. Front Immunol.
2013;4:316.
150. Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M,
Bernard GR. Acute respiratory distress syndrome clinical trials network lower tidal
volume ventilation and plasma cytokine markers of inflammation in patients with
acute lung injury. Crit Care Med. 2005;33(1):1–6.
151. Paul S, Mishra CM. Do we need to vaccinate every child against COVID-19:
What evidence suggests—A systematic review of opinions. Front Public Health
[Internet]. 2022 Nov 8 [cited 2023 Dec 12];10:1002992. Available from:
https://www.frontiersin.org/articles/10.3389/fpubh.2022.1002992/full
118
152. Peiris JSM, Lai ST, Poon LLM, Guan Y et al. and Members of the SARS
Study Group. Coronavirus as a possible cause of severe acute respiratory
syndrome. 2003. Lancet 361:1319–1325.
153. Pence BD, Yarbro JR. Aging impairs mitochondrial respiratory capacity in
classical monocytes. Exp Gerontol. 2018;108:112–7.
154. Phelan AL, Katz R, Gostin LO. The novel coronavirus originating in Wuhan,
China: challenges for global health governance. JAMA 2020; published online
Jan 30. DOI:10.1001/jama.2020.1097.
155. Pérez-Rodríguez P, de Bustamante MD, Mollá SA, Are-nas MC, JiménezArmero S, Esclapez PL, Boixareu CB. Functional, cognitive, and nutritional
decline in 435 elderly nursing home residents after the first wave of the COVID19 pandemic. Eur Geriatr Med. 2021:1–9. Epu 2021 Jun 24.PMID: 34165775.
PMCID: PMC8222945.
156. Pescarini, J.M.; Cardoso, A.M.; Santos, R.V.; Scaff, P.F.; Paixao, E.S.;
Ranzani, O.T.; Cerqueira-Silva, T.; Boaventura, V.S.; Bertoldo-Junior, J.; De
Oliveira, V.A.; et al. Vaccine coverage and effectiveness against laboratoryconfirmed symptomatic and severe Covid-19 in indigenous people in Brazil: A
cohort study. BMC Public Health 2023, 23, 1267.
157. Petrone, L.; Sette, A.; De Vries, R.D.; Goletti, D. The Importance of
Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic.
Pathogens 2023, 12, 862.
158. Pinti M, Appay V, Campisi J, Frasca D. Aging of the immune system: Focus
on inflammation and vaccination. Eur J Immunol. 2016;46:2286–301.
159. Price AM, Olson SM, Newhams MM, Halasa NB, Boom JA, Sahni LC, et al.
BNT162b2 Protection against the Omicron Variant in Children and Adolescents.
N Engl J Med [Internet]. 2022 May 19 [cited 2024 Mar 7];386(20):1899–909.
Available from: http://www.nejm.org/doi/10.1056/NEJMoa2202826
160. Primorac D, Vrdoljak K, Brlek P, Pavelić E, Molnar V, Matišić V, Erceg
Ivkošić I, Parčina M. Adaptive Immune Responses and Immunity to SARS-CoV-
119
2. Front Immunol. 2022 May 4;13:848582. doi: 10.3389/fimmu.2022.848582.
PMID: 35603211; PMCID: PMC9114812.
161. Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, Tian DS. Dysregulation of
immune response in patients with coronavirus 2019 (COVID-19) in Wuhan,
China. Clin Infect Dis. 2020;71(15):762–8.
162. Qing Ye, Bili W, Jianhua M. The pathogenesis and treatment of the ‘cytokine
storm’ in COVID-19. J Infect. 2020;80(6):607–13.
163. Rahimi A, Mirzazadeh A, Tavakolpour S. Genetics and genomics of SARSCoV-2: A review of the literature with the special focus on genetic diversity and
SARS-CoV-2 genome detection. Genomics. 2021 Jan;113(1 Pt 2):1221-1232.
doi: 10.1016/j.ygeno.2020.09.059. Epub 2020 Sep 30. PMID: 33007398; PMCID:
PMC7525243.
163. Ramos-Casals M, Brito-Zerón P, López-Guillermo A, Khamashta MA, Bosch
X. Adult haemophagocytic syndrome. Lancet. 2014;383(9927):1503–16.
164. Ranzani, O.T.; Hitchings, M.D.T.; Dorion, M.; D’Agostini, T.L.; De Paula,
R.C.; De Paula, O.F.P.; Villela, E.F.D.M.; Torres, M.S.S.; De Oliveira, S.B.;
Schulz,W.; et al. Effectiveness of the CoronaVac vaccine in older adults during a
gamma variant associated epidemic of covid-19 in Brazil: Test negative casecontrol study. BMJ 2021, 374, n2015.
165. Reinscheid M, Luxenburger H, Karl V, Graeser A, Giese S, Ciminski K, et
al. COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell
responses while conserving the memory pool for subsequent reactivation. Nat
Commun [Internet]. 2022 Aug 8 [cited 2023 Dec 6];13(1):4631. Available from:
https://www.nature.com/articles/s41467-022-32324-x
166. Reis BY, Barda N, Leshchinsky M, Kepten E, Hernán MA, Lipsitch M, et al.
Effectiveness of BNT162b2 Vaccine against Delta Variant in Adolescents. N Engl
J Med [Internet]. 2021 Nov 25 [cited 2024 Mar 7];385(22):2101–3. Available from:
http://www.nejm.org/doi/10.1056/NEJMc2114290
167. Reis-Goes FS, Silva NN, Gondim TM, Figueiredo RG, Evangelista GAO,
Marchioro SB, Costa RS, Torres AJL, Meyer RJ, Trindade SC, Fortuna V.
120
Exploring dysregulated immune response genes and endothelial dysfunction
biomarkers as predictors of severe COVID-19. Int Immunopharmacol. 2023
Sep;122:110610. doi: 10.1016/j.intimp.2023.110610. Epub 2023 Jul 5. PMID:
37453154.
168. Ribeiro, A.A.; Rossi, L.A. COVID-19 pandemic and the motivations for
demanding health service in indigenous villages. Rev.Bras. Enferm. 2020, 73,
e20200312.
169. Ricardo CA, Ricardo FP. Povos indígenas no Brasil: 2006-2010. São Paulo:
Instituto Socioambiental; 2011. 435-94 pp.
170. Rijhsinghani AG, Thompson K, Bhatia SK, Waldschmidt TJ. Estrogen blocks
early T cell development in the thymus. Am J Reprod Immunol. 1996;36(5):269-
77.
171. Ritchie AI, Singanayagam A. Immunosuppression for hyperinflammation in
COVID-19: A double-edged sword? Lancet. 2020;395(10230):1111.
172. Rivas-Rodríguez E, Amezcua L. Ethnic considerations and multiple
sclerosis disease variability in the United States. Neurol Clin. 2018;36(1):151-62.
173. Rodrigues DA. Epidemiological Invisibility Characterizes Brazilian Native
Indians’ Health. Rev Paul Pediatr. 2018;36(2):122.
174. Rothenberg E. Coronavirus disease 19 from the perspective of ageing with
focus on nutritional status and nutrition management—a narrative review.
Nutrients. 202;13(4):1294.
175. Ruan Q,Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality
due to COVID-19 based on an analysis of data of 150 patients from Wuhan,
China. 2020. doi: 10.1007/S00134-020-05991-X.
176. Sacramento RH, Carvalho Araújo FM, Lima DM, Alencar CC, Martins VE,
Araújo LV, et al. Dengue Fever and Aedes aegypti in indigenous Brazilians:
seroprevalence, risk factors, knowledge and practices. Trop Med Int Health.
2018;23(6):596-604.
121
177. Saadati Z, Haghshenas MR, Rezaeifard S, Heidari F, Erfani N. Reference
Ranges of Lymphocyte Subsets in Healthy Individuals from Southern Iran. Clin
Lab. 2022;68(10).
178. Sadeghi HM, Schnelle JF, Thomas JK, Nishanian P, Fahey JL. Phenotypic
and functional characteristics of circulating monocytes of elderly persons. Exp
Gerontol. 1999;34(8):959–70.
179. Saare M, Tserel L, Haljasmägi L, Taalberg E, Peet N, Eimre M, Peterson P.
Monocytes present age-related changes in phospholipid concentration and
decreased energy metabolism. Aging Cell. 2020;19(4):e13127.
180. Saini S.K., Hersby D.S., Tamhane T., H.R. Povlsen, S.P.A. Hernandez, M.
Nielsen, A.O. GANG, S.R. HADRUP. SARS-CoV-2 genome-wide T cell epitope
mapping reveals immunodominance and substantial CD8+ T cell activation in
COVID-19 patients. Sci. Immunol. 6 (2021),
https://doi.org/10.1126/sciimmunol.abf7550.
181. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and
immune tolerance. Cell. 2008;133(5):775–87.
182. Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T
cells in the human immune system. Nat Rev Immunol. 2010;10(7):490–500.
183. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of
memory T lymphocytes with distinct homing potentials and effector functions.
Nature.1999;401(6754):708–12.
184. Samanovic MI, Cornelius AR, Gray-Gaillard SL, Allen JR, Karmacharya T,
Wilson JP, et al. Robust immune responses after one dose of BNT162b2 mRNA
vaccine dose in SARS-CoV-2 experienced individuals [Internet]. Infectious
Diseases (except HIV/AIDS); 2021 Feb [cited 2023 Dec 6]. Available from:
http://medrxiv.org/lookup/doi/10.1101/2021.02.07.21251311
185. Schultz, B.M.; Melo-González, F.; Duarte, L.F.; Gálvez, N.M.S.; Pacheco,
G.A.; Soto, J.A.; Berríos-Rojas, R.V.; González, L.A.; Moreno-Tapia, D.; RiveraPérez, D.; et al. A Booster Dose of CoronaVac Increases Neutralizing Antibodies
122
and T Cells that Recognize Delta and Omicron Variants of Concern. mBio 2022,
13, e01423-22.
186. Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F. Agedependent alterations of monocyte subsets and monocyte-related chemokine
pathways in healthy adults. BMC Immunol. 2010;11:30.
187. Sellami M, Gasmi M, Denham J, Hayes LD, Stratton D, Padulo J, Bragazzi
N. Effects of acute and chronic exercise on immunological parameters in the
elderly aged: Can physical activity counteract the effects of aging? Front
Immunol. 2018;9:2187.
188. Sekine T, Perez-Potti A, Rivera-Ballesteros O, Strålin K, Gorin J-B, Olsson
A, S. Llewellyn-Lacey, H. Kamal, G. Bogdanovic, S. Muschiol, D.J. Wullimann, T.
Kammann, J. Emgård, T. parrot, E. Folkesson, O. Rooyackers, L.I. Eriksson, J.-
I. Henter, A. S¨Onnerborg, T. Allander, J. Albert, M. Nielsen, J. Klingstr¨OM, S.
Gredmark-Russ, N.K. BJ¨Orkstr¨OM, J.K. Sandberg, D.A. Price, H.-G. Ljunggren,
S. Aleman, M. Buggert. Robust T cell immunity in convalescent individuals with
asymptomatic or mild COVID-19. Cell 183 (2020) 158–168,
https://doi.org/10.1016/j.cell.2020.08.017, e14.
189. Sette, A.; Crotty, S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell
2021, 184, 861–880.
190. Shakya G, Dumre SP, Malla S, Sharma M, Kc KP, Chhetri DB, et al. Values
of lymphocyte subsets in Nepalese healthy adult population. JNMA J Nepal Med
Assoc. 2012;52(185):6-13.
191. Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone CC, Dauphin A. Innate
lymphoid cells and disease tolerance in SARS-CoV-2 infection [Preprint];
available from
https://www.medrxiv.org/content/10.1101/2021.01.14.21249839v2.
192. Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A, Porter JD,
Johnston SL. Corticosteroid suppression of antiviral immunity increases bacterial
loads and mucus production in COPD exacerbations. Nat Commun.
2018;9(1):2229.
123
193. Smits SL, De Lang A, Van Den Brand JM, Leijten LM, Van Ijcken WF,
Eijkemans MJ, Van Amerongen G, Kuiken T, Andeweg AC, Osterhaus AD,
Haagmans BL. Exacerbated innate host response to SARS-CoV in aged nonhuman primates. PLoS Pathog. 2010;6(2):e1000756.
194. Qing Ye, Bili W, Jianhua M. The pathogenesis and treatment of the ‘cytokine
storm’ in COVID-19. J Infect. 2020;80(6):607–13.
195. Snijder, EJ, Bredenbeek PJ, Dobbe JC et al. Unique and conserved features
of genome and proteome of SARS-coronavirus, an early split-off from the
coronavirus group 2 lineage. J. Mol. Biol. 2003. 331:991–1004.
196. Sorrenti V, Marenda B, Fortinguerra S, Cecchetto C, Quartesan R, Zorzi G,
et al. Reference values for a panel of cytokinetic and regulatory lymphocyte
subpopulations. Immune Netw. 2016;16(6):344-57.
197. Soysal, A.; Bilazer, C.; Gönüllü, E.; Barın, E.; Çivilibal, M. Cord blood
antibody following maternal SARS-CoV-2 inactive vaccine (CoronaVac)
administration during the pregnancy. Hum. Vaccines Immunother. 2021, 17,
3484–3486.
198. Su S, Wong G, Shi W, Liu J, Lai ACK, Zhou J, Liu W, Bi Y, Gao GF.
Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses.
Trends Microbiol. 2016 Jun;24(6):490-502. doi: 10.1016/j.tim.2016.03.003. Epub
2016 Mar 21. PMID: 27012512; PMCID: PMC7125511.
199. Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, Yi F, Yang HC, Fogo AB,
Nie X, Zhang C. Renal histopathological analysis of 26 postmortem findings of
patients with COVID-19 in China. Kidney Int. 2020 Jul;98(1):219-227. doi:
10.1016/j.kint.2020.04.003. Epub 2020 Apr 9. PMID: 32327202; PMCID:
PMC7194105.
200. Sun JC, Lanier LL. NK Cell Development, Homeostasis and Function:
Parallels With CD8+ T Cells. Nat Rev Immunol (2011) 11:645. doi:
10.1038/NRI3044
124
201. Sunagar, R.; Singh, A.; Kumar, S. SARS-CoV-2: Immunity, Challenges with
Current Vaccines, and a Novel Perspective on Mucosal Vaccines. Vaccines
2023, 11, 849.
202. Suryawanshi, Y.N.; Biswas, D.A. Herd Immunity to Fight Against COVID-19:
A Narrative Review. Cureus 2023, 15, e33575.
203. Tanriover, M.D.; Do ˘ganay, H.L.; Akova, M.; Güner, H.R.; Azap, A.; Akhan,
S.; Köse, ¸S.; Erdinç, F. ¸S.; Akalın, E.H.; Tabak, Ö.F.; et al. Efficacy and safety
of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): Interim results
of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey. Lancet
2021, 398, 213–222.
204. Terpos, Evangelos et al. Hematological findings and complications of
COVID-19. Am J Hematol. v.95, n. 7, p. 834-847. 2020.
205. Thakar MR, Abraham PR, Arora S, Balakrishnan P, Bandyopadhyay B,
Joshi AA, et al. Establishment of reference CD4+ T cell values for adult Indian
population. AIDS Res Ther. 2011;8(1):35.
206. Thomas BJ, Porritt RA, Hertzog PJ, Bardin PG, Tate MD.
Glucocorticosteroids enhance replication of respiratory viruses: Effect of adjuvant
interferon. Sci Rep. 2014;4:7176.
207. Tollerud DJ, Clark JW, Brown LM, Neuland CY, Pankiw-Trost LK, Blattner
WA, et al. The influence of age, race, and gender on peripheral blood
mononuclear-cell subsets in healthy nonsmokers. J Clin Immunol. 1989;9(3):214-
22.
208. Toh ZQ, Anderson J, Mazarakis N, Neeland M, Higgins RA, Rautenbacher
K, et al. Comparison of Seroconversion in Children and Adults With Mild COVID19. JAMA Netw Open [Internet]. 2022 Mar 9 [cited 2024 Mar 1];5(3):e221313.
Available from:
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789845
209. Torres AJ, Angelo AL, Silva MO, Bastos MC, Souza DF, Inocêncio LA, et al.
Establishing the reference range for T lymphocytes subpopulations in adults
125
and children from Brazil. Rev Inst Med Trop São Paulo. 2013;55(5):323-8.
210. Torres AJL, Marchioro SB, Ribeiro MB, DE Morais IRB, Freire SM,
Nascimento RJM. Severe Cases of COVID-19 and High Association with Causes
of Immune Dysregulation: A Systematic Review. Crit Rev Immunol.
2021;41(3):15-25. doi: 10.1615/CritRevImmunol.2021039675. PMID: 35378008.
211. Tosif S, Neeland MR, Sutton P, Licciardi PV, Sarkar S, Selva KJ, et al.
Immune responses to SARS-CoV-2 in three children of parents with symptomatic
COVID-19. Nat Commun [Internet]. 2020 Nov 11 [cited 2024 Mar 7];11(1):5703.
Available from: https://www.nature.com/articles/s41467-020-19545-8
212. Touil N, Hadef R, Lemnouer A, Zrara A, Sbai AI, Belfquih B, et al. Rangereference determination of lymphocyte subsets in Moroccan blood donors. Afr
Health Sci. 2012;12(3):334-8.
213. Tregoning, J.S.; Flight, K.E.; Higham, S.L.;Wang, Z.; Pierce, B.F. Progress
of the COVID-19 vaccine effort: Viruses, vaccines and variants versus efficacy,
effectiveness and escape. Nat. Rev. Immunol. 2021, 21, 626–636.
214. Tufan A, Aslihan AG, Matucci-Cerinic M. COVID-19, immune system
response, hyperinflammation and repurposing antirheumatic drugs. Turk J Med
Sci. 2020;50(SI-1):620–32.
215. Tynell J, Westenius V, Rönkkö E, Munster VJ, Melén K, Österlund P,
Julkunen I. Middle East respiratory syndrome coronavirus shows poor replication
but significant induction of antiviral responses in human monocyte-derived
macrophages and dendritic cells. J Gen Virol. 2016;97(2):344–55.
216. Van Beek AA, Van den Bossche J, Mastroberardino PG, DeWinther MP,
Leenen PJ. Metabolic alterations in aging macrophages: Ingredients for
inflammaging? Trends Immunol. 2019;40(2):113–27.
217. Van Den Hoek L, Pyr K, Jebbink MF, Vermeulen-oost W et al. Identification
of a new human coronavirus. Nat. Med. 2004. 10:368–373.
218. Van Deursen JM. The role of senescent cells in ageing. Nature.
2014;509:439–46.
126
219. Van der Ploeg HP, Chey T, Korda RJ, Banks E, Bauman A. Sitting time and
all-cause mortality risk in 222,497 Australian adults. Arch Intern Med.
2012;172(6):494–500.
220. Verdeccia P, Cavallini C, Spanevello A, Angeli F. The pivotal link between
ACE2 deficiency and SARS-CoV-2 infection. Eur J Intern Med. 2020;76:14–20.
221. Xia Y, Liu A, Li W, Liu Y, Zhang G, Ye S, et al. Reference range of naïve T
and T memory lymphocyte subsets in peripheral blood of healthy adult. Clin Exp
Immunol. 2022;207(2):208-17.
222. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Wang FS. Pathological
findings of COVID-19 associated with acute respiratory distress syndrome.
Lancet Respir Med. 2020;8(4):420–2.
223. Wall TL, Luczak SE, Hiller-Sturmhöfel S. Biology, genetics, and
environment: underlying factors influencing alcohol metabolism. Alcohol Res.
2016; 38(1):59-68.
224. Wan S, Yi Q, Fan S, Lv J, Zhang X, Guo L, Chen Y. Characteristics of
lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients
with 2019 novel coronavirus pneumonia (NCP) [Preprint]. Available from:
https://www.medrxiv.org/content/10.1101/2020.02.10.20021832v1.
225. Wang D, Bo H, Chang H. Clinical characteristics of 138 hospitalized patients
with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA.
2020;323(11):1061–9.
226. Wang F, Nie J, Wang H, Zhao Q, Xiong Y, Deng L, Zhang Y. Characteristics
of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis.
2020;221(11):1762–9.
227. Wang H, Ma S. The cytokine storm and factors determining the sequence
and severity of organ dysfunction in multiple organ dysfunction syndrome. Am J
Emerg Med. 2008;26(6):711–5.
228. Wang X, Tan L, Wang X, Liu W, Lu Y, Cheng L, Sun Z. Comparison of
nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 detection in 353
127
patients received tests with both specimens simultaneously. Int J Infect Dis. 2020
May; 94:107-109. doi: 10.1016/j.ijid.2020.04.023. Epub 2020 Apr 18. PMID:
32315809; PMCID: PMC7166099.
229. Wang K, et al., SARS-CoV-2 invades host cells via a novel route: CD147-
spike protein, bioRxiv (2020), p. 2020.03.14.988345.
230. Wang Z, et al., Clinical features of 69 cases with coronavirus disease 2019
in Wuhan, China, Clin. Infect. Dis. (2020).
231. Watad A, Bragazzi NL, Adawi M, Amital H, Toubi E, Porat BS, ShoenfeldY.
Autoimmunity in the elderly: Insights from basic science and clinics – A minireview. Gerontology. 2017;63(6):515–23.
232. Who. SAGE Who Value Model for Allocating and Prioritizing COVID-19
Vaccination. 14 September 2020. Available online:
https://iris.paho.org/bitstream/handle/10665.2/52797/OPASWBRAPHECOVID1920116_por.pdf?sequence=1&isAllowed=y (accessed on 14 December 2023).
233. Wong WS, Lo AW, Siu LP, Leung JN, Tu SP, Tai SW, et al. Reference
ranges for lymphocyte subsets among healthy Hong Kong Chinese adults by
single-platform flow cytometry. Clin Vaccine Immunol. 2013;20(4):602-6.
234. Woo PCY, Lau SKP, Chu CM et al. Characterization and complete genome
sequence of a novel coronavirus HKU-1 from patients with pneumonia. J. Virol.
2005. 79:884–895.
235. World Health Organization (2020) Transmission of SARS-CoV-2:
implications for infection prevention precautions: scientific brief, 09 July 2020.
World Health Organization, Geneva.
236. World Health Organization (WHO). Coronavirus disease (COVID-2019)
situation reports. 2021 March 16; no. 46; Accessed 9 April 2021. Available from:
https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situationreports.
237. World Health Organization. Weekly Epidemiological Record Relevé
Épidémiologique Hebdomadaire. 2023. Available online:
128
https://iris.who.int/bitstream/handle/10665/373831/WER9844-eng-fre.pdf
(accessed on 14 December 2023).
238. Yalçın, T.Y.; Topçu, D.˙I.; Do ˘gan, Ö.; Aydın, S.; Sarı, N.; Erol, Ç.; Kulo ˘glu,
Z.E.; Azap, Ö.K.; Can, F.; Arslan, H. Immunogenicity after two doses of
inactivated virus vaccine in healthcare workers with and without previous COVID19 infection: Prospective observational study. J. Med. Virol. 2022, 94, 279–286.
239. Yang Y, Shen C, Li J, Yuan J, Yang M, Wang F, Liu Y. Exuberant elevation
of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with
disease severity and fatal outcome [Preprint]. Available from:
https://www.medrxiv.org/content/10.1101/2020.03.02.200299 75v1.
240. Yang L, Liu S, Liu J, Zhang Z, Wan X, Huang B, Chen Y, Zhang Y. COVID19: immunopathogenesis and Immunotherapeutics. Signal Transduct Target
Ther. 2020 Jul 25;5(1):128. doi: 10.1038/s41392-020-00243-2. PMID: 32712629;
PMCID: PMC7381863.
241. Yang L, Liu S, Liu J, Zhang Z, Wan X, Huang B, Chen Y, Zhang Y. COVID19: immunopathogenesis and Immunotherapeutics. Signal Transduct Target
Ther. 2020 Jul 25;5(1):128. doi: 10.1038/s41392-020-00243-2. PMID: 32712629;
PMCID: PMC7381863.
242. Yang H, Xie Y, Li C. Understanding the mechanisms for COVID-19 vaccine's
protection against infection and severe disease. Expert Rev Vaccines. 2023 JanDec;22(1):186-192. doi: 10.1080/14760584.2023.2174529. PMID: 36715150.
243. Yan X, Chen G, Jin Z, Zhang Z, Zhang B, He J, et al. Anti-SARS-CoV-2 IgG
Levels in Relation to Disease Severity of COVID-19. J Med Virol (2022)
94:380–3. doi: 10.1002/JMV.27274
244. Yang X, Yu Y, Xu J, Shu H, Liu H, Wu Y, Zhang L. Clinical course and
outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China:
A single centered, retrospective observational study. Lancet Respir Med.
2020;8(5):475–81.
129
245. Yarbro JR, Pence BD. Classical monocytes from older adults maintain
capacity for metabolic compensation during glucose deprivation and
lipopolysaccharide stimulation. Mech Ageing Dev. 2019;83:111146.
246. Yasmon A, Ibrahim F, Bela B, Sjahrurachman A. Potential cross-reactivity
of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)
nucleocapsid (N)-based IgG ELISA assay for plasma samples from HIV-1
positive intravenous drug users (IDUs). Acta Med Indones. 2012;44:193–8.
247. Yu ED, Wang H, Silva Antunes R, Tian Y, Tippalagama R, Alahakoon SU,
et al. A Population of CD4+CD8+ Double-Positive T Cells Associated with Risk
of Plasma Leakage in Dengue Viral Infection. Viruses. 2022;14(1):90.
248. Yvan J, Thomas H, Alexandre B. Should we stimulate or suppress immune
responses in COVID-19? Cytokine and anti-cytokine interventions. Autoimmun
Rev. 2020;19(7):102567.
249. Zhang J., Dong X., Liu G., Gao Y. Risk and Protective Factors for COVID19 Morbidity, Severity, and Mortality. Clin. Rev. Allergy Immunol. 64 (1) (Jan.
2022) 90–107, https://doi.org/10.1007/s12016-022-08921-5.
250. Zervou FN, Louie P, Stachel A, Zacharioudakis IM, Ortiz-Mendez Y, Thomas
K, et al. SARS-CoV-2 Antibodies: IgA Correlates With Severity of Disease in Early
COVID-19 Infection. J Med Virol (2021) 93:5409–15. doi: 10.1002/JMV.27058
251. Zhang D, Guo R, Lei L, Liu H, Wang Y, Wang Y, Hu, J. COVID-19 infection
induces readily detectable morphologic and inflammation-related phenotypic
changes in peripheral blood monocytes. J Leukoc Biol. 2020; 109(1):13–22.
252. Zhang L, et al., Crystal structure of SARS-CoV-2 main protease provides a
basis for design of improved α-ketoamide inhibitors, Science 368 (6489) (2020)
409–412.
253. Zhao T, Huang X, Shu Y. Comparing the immune response and protective
effect of COVID-19 vaccine under different vaccination strategies. Hum Vaccin
Immunother. 2023 Dec 15;19(3):2273155. doi:
10.1080/21645515.2023.2273155. Epub 2023 Dec 19. PMID: 38111370;
PMCID: PMC10732654.
130
254. Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y, Zuo W. Single cell RNA expression
profiling of ACE2, the receptor of SARS-CoV-2. Am J Respir Crit Care Med.
2020;202(5):756–9.
255. Zhou P. A Pneumonia outbreak associated with a new coronavirus of
probable bat origin. Nature. 2020; 579(7798):270–3.
256. Zhou J, Chu H, Li C, Wong BHY, Cheng ZS, Poon VKM, Yuen KY. Active
replication of Middle East respiratory syndrome coronavirus and aberrant
induction of inflammatory cytokines and chemokines in human macrophages:
Implications for pathogenesis. J Infect Dis. 2014;209(9):1331–42. 44.
257. Zhu N, Zhang D,Wang C, Li , Yang B. A novel coronavirus from patients with
pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–33.
258. Ziegler-Heitbrock, L. et al.. "Nomenclature of monocytes and dendritic cells
in blood". Blood. (2010)116 (16):e74–e80. doi:10.1182/blood-2010-02-258558.
PMID 20628149. | pt_BR |
