Caracterização morfológica e clínica do Carcinoma em Tumor Misto grau I “atípico” da mama de cadelas e sua correlação com a sobrevida

Abstract

Carcinoma in a mixed tumor is the most frequent malignant mammary neoplasia in female dogs, and some characteristics give it a greater potential for malignancy, such as areas with a micropapillary proliferative pattern or the highest histological grade. Thus, the objective of this study was to carry out the clinical, epidemiological and anatomo-histopathological characterization of carcinomas in mixed tumors, determining which morphological characteristics contribute to the “atypical” behavior of Grade I CMT with nodal metastasis. compare with CMT grade II and correlate with survival rates. We selected 100 cases of carcinomas in mixed tumors (CMT) subdivided based on histological grading and regional lymph node involvement [(48 CMT I (-), 16 CMT I (+), 23 CMT (-), 13 CMT (+) Clinical, epidemiological and histopathological information regarding the mammary and regional lymph node tumor was reevaluated. It was found that in CMT I and CMT II, the size of the tumor and the time of detection reflect on the patients' prognosis, CTM I (+) present a low survival rate and histopathological characteristics similar to CMT II (+), such as myxoid matrix associated with mature tissue, papillary arrangement, lymphohistioplasmocytic inflammation, greater desmoplasia and lesser number of peri and intratumoral vessels. , unlike most cases, of primary tumors. It is concluded that for the reliable evaluation of carcinomas in mixed tumors, in addition to the histopathological degree, it is necessary to study the myopithelial cells and possible adaptations in the grading system, adding morphological characteristics that may be related to greater tumor aggressiveness such as extracellular matrix, desmoplasia, presence and type of inflammation, angiogenesis and invasion. This study contributes to the identification of predictive characteristics of metastases in bitches with low-grade but highly aggressive CMT.