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Campo DCValorIdioma
dc.creatorBorges, Tiago Silva-
dc.date.accessioned2024-10-29T13:33:44Z-
dc.date.available2025-03-06-
dc.date.available2024-10-29T13:33:44Z-
dc.date.issued2024-03-06-
dc.identifier.citationBORGES, Tiago Silva. Compostos bioativos, potencial antioxidante, antimicrobiano, citotóxico e neuroprotetor de própolis verde comercial e in natura. 2024. 126 f. Dissertação (Mestrado em Bioquímica e Biologia Molecular) - Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, 2024.pt_BR
dc.identifier.urihttps://repositorio.ufba.br/handle/ri/40515-
dc.description.abstractDifferent types of propolis are popular in various regions of Brazil, containing complex chemical components, mainly flavonoids and polyphenols, which vary according to geographical location, plant species, and the season in which they are produced. For example, green propolis is produced by Apis mellifera bees that use Baccharis dracunculifolia, a common species found in the Brazilian savannah. This study aims to evaluate Brazilian green propolis, both in nature and commercial, regarding its antioxidant, antimicrobial, cytotoxic, and neuroprotective potential, correlating these aspects with its chemical profile. To achieve this, propolis extracts in nature were used to prepare ethanolic, aqueous, and ethyl acetate extracts. The commercial aqueous and ethanolic extracts were obtained from Favo de Ouro Company, a laboratory partner. Phytochemical screening, a colorimetric and qualitative method, was used to characterize the extracts, assessing the presence of secondary metabolites. The crude extracts of green propolis and the aqueous and ethanolic solutions of commercial green propolis showed similarities in the presence of secondary metabolites. On the other hand, the aqueous and ethanolic extracts of green propolis in nature stood out due to the presence of saponins. Antimicrobial activity was evaluated by broth dilution. The crude extracts in ethanol and ethyl acetate proved effective against Staphylococcus aureus at concentrations of 125 and 250 μgmL-1, respectively. The commercial aqueous solution was also effective against Escherichia coli. Cytotoxic and neuroprotective evaluation in PC12 cells for 48 hours showed that most extracts were not toxic, except for the commercial ethanolic solution, which exhibited toxicity. Regarding neuroprotective activity, the aqueous and ethyl acetate crude extracts, at concentrations of 11 and 5.5 μgmL-1, respectively, showed promising results. Propolis analysis by GC-MS enabled the identification of a variety of compounds, such as terpenes, phenols, acids, aldehydes, and fatty acids, depending on the specific composition of the sample. This technique is essential for a detailed characterization of the chemical constituents present in propolis, providing valuable insights into its chemical composition.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal da Bahiapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectFlavonoidespt_BR
dc.subjectPerfil químicopt_BR
dc.subjectMedicina tradicionalpt_BR
dc.subject.otherFlavonoidspt_BR
dc.subject.otherMetabolomic profilept_BR
dc.subject.otherTraditional medicinept_BR
dc.titleCompostos bioativos, potencial antioxidante, antimicrobiano, citotóxico e neuroprotetor de própolis verde comercial e in naturapt_BR
dc.title.alternativeBioactive compounds, antioxidant, antimicrobial, cytotoxic and neuroprotective potential of commercial and fresh green propolispt_BR
dc.typeDissertaçãopt_BR
dc.publisher.programPrograma de Pós-Graduação Multicêntrico em Bioquímica e Biologia Molecular (PMBqBM) pt_BR
dc.publisher.initialsUFBApt_BR
dc.publisher.countryBrasilpt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICApt_BR
dc.contributor.advisor1Fernandez, Luzimar Gonzaga-
dc.contributor.advisor1IDhttps://orcid.org/0000-0003-0837-6101pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/5869970809916591pt_BR
dc.contributor.referee1Fernandez, Luzimar Gonzaga-
dc.contributor.referee1IDhttps://orcid.org/0000-0003-0837-6101pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/5869970809916591pt_BR
dc.contributor.referee2Rabbani, Allívia Rouse Carregosa-
dc.contributor.referee2IDhttps://orcid.org/0000-0003-0564-7113pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/9716789774090901pt_BR
dc.contributor.referee3Paiva, Patrícia Maria Guedes-
dc.contributor.referee3IDhttps://orcid.org/0000-0003-3467-708Xpt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/2885145995086459pt_BR
dc.creator.Latteshttps://lattes.cnpq.br/4256554480083930pt_BR
dc.description.resumoOs diferentes tipos de própolis são populares em diversas regiões do Brasil, contendo componentes químicos complexos, principalmente flavonoides e polifenóis, que variam de acordo com a localização geográfica, as espécies vegetais e a estação do ano em que são produzidos. A própolis verde, por exemplo, é produzida por abelhas Apis mellifera que utilizam Baccharis dracunculifolia, uma espécie comum encontrada no cerrado brasileiro. Este estudo visa avaliar a própolis verde brasileira, tanto in natura quanto comercial, em relação ao seu potencial antioxidante, antimicrobiano, citotóxico e neuroprotetor, correlacionando esses aspectos com seu perfil químico. Para isso, foram utilizados extratos de própolis in natura para preparar extratos etanólico, aquoso e em acetato de etila. Os extratos comerciais aquoso e etanólico foram obtidos através da Empresa Favo de Ouro. A triagem fitoquímica, um método colorimétrico e qualitativo, foi utilizado para caracterizar os extratos, avaliando a presença de gupos químicos. Os extratos brutos de própolis verde e as soluções aquosas e etanólicas de própolis verde comercial apresentaram semelhanças quanto aos grupos químics presentes. Por outro lado, os extratos aquoso e etanólico de própolis verde in natura se distinguiram dos demais devido à presença de saponinas. A atividade antimicrobiana foi avaliada por diluição em caldo. Os extratos brutos em etanol e acetato de etila mostraram-se eficazes contra Staphylococcus aureus em concentrações de 125 e 250 μgmL-1, respectivamente. O extrato comercial em solução aquosa também foi eficaz contra Escherichia coli. A avaliação citotóxica e neuroprotetora em células PC12 durante 48 horas mostrou que a maioria dos extratos não foi tóxica, exceto o extrato comercial em solução etanólica, que apresentou toxicidade. Quanto à atividade neuroprotetora, os extratos brutos aquoso e em acetato de etila, nas concentrações de 11 e 5,5 μgmL-1, respectivamente, mostraram resultados promissores. A análise de própolis por GC-MS possibilitou a identificação de uma variedade de compostos, como terpenos, fenóis, ácidos, aldeídos e ácidos graxos, dependendo da composição específica da amostra. Essa técnica é essencial para uma caracterização detalhada dos constituintes químicos presentes na própolis, oferecendo insights valiosos sobre sua composição química.pt_BR
dc.publisher.departmentInstituto de Ciências da Saúde - ICSpt_BR
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