Relação entre resposta inflamatória sistêmica e carga pró-viral com doença periodontal associada ao HTLV-1

Abstract

Introduction: HTLV-1 is associated with the occurrence of periodontitis. The reason why the Individuals infected with HTLV-1 develop periodontal disease is not known. Objectives: To evaluate the association between proviral load, inflammatory cytokines and disease periodontal disease in individuals carrying HTLV-1. Materials and Methods: Cutting study cross-sectional study carried out at the Multidisciplinary HTLV-1 Outpatient Clinic of the Hospital Complex University Professor Edgard Santos. The periodontium of 80 patients infected by HTLV-1 with and without periodontal disease was assessed by probing. Spontaneous production of cytokines and pro-viral load were used for the most recent analysis registered in the database data from the Immunology Service. Results: Eighty individuals infected with HTLV-1 were included, 40 with periodontal disease and 40 without periodontal disease. A median proviral load and interquartile range in individuals without and with disease periodontal was 14915.0 (IQ 1333.750 - 47195.900) and 18863.5 (IQ 1348.750 - 68631.250), respectively, with p>0.5. TNF production in infected patients by HTLV-1 without periodontal disease was 17.0 pg/ml and in patients infected by HTLV-1 with periodontal disease was 43.0 pg/ml with p>0.5. IFN production was 362.5 pg/ml and 885.0 pg/ml, respectively, p>0.5. There was no difference regarding the production of IL-10 and occurrence of periodontal disease, with p>0.5. Not observed difference between proviral load, IFN, TNF and IL-10 in relation to the severity of periodontitis. Conclusion: The lack of relationship between systemic inflammatory response and proviral load with HTLV-1-associated periodontal disease indicates that other factors in addition to proviral load and the immune response are involved in the migration of HTLV-1 to the periodontium.