1. Universidade Federal da Bahia
  2. Instituto de Ciências da Saúde (ICS)
  3. Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas (PPGPIOS)
  4. Dissertação (PPGPIOS)
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/39038
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Campo DCValorIdioma
dc.creatorAzevedo, Juliana Santos de Jesus-
dc.date.accessioned2024-02-19T15:59:17Z-
dc.date.available2024-02-19T15:59:17Z-
dc.date.issued2023-12-20-
dc.identifier.citationAZEVEDO, Juliana Santos de Jesus. Influência do infiltrado inflamatório subepitelial nas características do tecido epitelial das lesões de líquen plano oral: estudo morfológico. 2023. 80 f. Dissertação (Mestrado) - Universidade Federal da Bahia, Instituto de Ciências da Saúde, Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Salvador, 2023.pt_BR
dc.identifier.urihttps://repositorio.ufba.br/handle/ri/39038-
dc.description.abstractIntroduction: Oral lichen planus (OLP) is a chronic inflammatory disease, considered a potentially malignant oral disorder, which immunological mechanisms are associated with its development. It is believed that the pathogenesis of OLP is related to an intense subepithelial inflammatory infiltrate, that plays an important role in the damage suffered by the epithelial tissue. Chronic inflammation has also been strongly associated with the malignancy of this condition. Objective: To verify the association between the severity of the inflammatory infiltrate and epithelial characteristics observed in OLP lesions. Materials and methods: This is a retrospective cross-sectional study, with a sample comprising a total of 41 histological sections of OLP stained with Hematoxylin-Eosin, belonging to the Oral Pathology Laboratories of two higher education institutions in Bahia. Histological analyzes were performed using a light optical microscope with 10x and 40x objectives. The morphological aspects evaluated were: the presence and count of Civatte bodies, lymphocytic exocytosis, degeneration of the basal layer and the degree of tissue inflammation. Results: In the studied sample, there was a prevalence of severe tissue inflammation (85.4%). The prevalence of exocytosis, degeneration of the basal layer and civatte bodies were 72.5%, 82.9% and 76.3%, respectively. There was no significant association between the degree of tissue inflammation and the presence of exocytosis, degeneration of the basal layer and Civatte bodies (p>0.05). It wasn’t observed a significant difference in the amount of Civatte bodies between the different degrees of concentration (p>0.05) and there was no significant association between the presence of exocytosis and the presence of degeneration of the basal layer and Civatte bodies (p>0 .05). The number of Civatte bodies did not differ significantly between samples with absence or presence of exocytosis (p>0.05). Conclusion: In this study, no significant associations were found between the severity of the subepithelial inflammatory infiltrate and the characteristics confirmed in the epithelial tissue of OLP cases.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal da Bahiapt_BR
dc.rightsCC0 1.0 Universal*
dc.subjectLíquen plano bucalpt_BR
dc.subjectAchados morfológicos e microscópicospt_BR
dc.subjectEpitéliopt_BR
dc.subjectTecido conjuntivopt_BR
dc.subjectInflamaçãopt_BR
dc.subject.otherLichen Planus, Oralpt_BR
dc.subject.otherMorphological and Microscopic Findingspt_BR
dc.subject.otherEpitheliumpt_BR
dc.subject.otherConnective Tissuept_BR
dc.subject.otherInflammationpt_BR
dc.titleInfluência do infiltrado inflamatório subepitelial nas características do tecido epitelial das lesões de líquen plano oral: estudo morfológicopt_BR
dc.title.alternativeInfluence of subepithelial inflammatory infiltrate on epithelial tissue characteristics in oral lichen planus lesions: a morphological studypt_BR
dc.typeDissertaçãopt_BR
dc.publisher.programPrograma de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas (PPGORGSISTEM) pt_BR
dc.publisher.initialsUFBApt_BR
dc.publisher.countryBrasilpt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.contributor.advisor1Martins, Gabriela Botelho-
dc.contributor.advisor1IDhttps://orcid.org/0000-0002-0917-4598pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/0714029268066739pt_BR
dc.contributor.referee1Reis, Silvia Regina de Almeida-
dc.contributor.referee1IDhttps://orcid.org/0000-0003-1195-0485pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/8303067207035877pt_BR
dc.contributor.referee2Martins, Gabriela Botelho-
dc.contributor.referee2IDhttps://orcid.org/0000-0002-0917-4598pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/0714029268066739pt_BR
dc.contributor.referee3Medrado, Alena Ribeiro Alves Peixoto-
dc.contributor.referee3IDhttps://orcid.org/0000-0003-4074-4680pt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/5438084603507436pt_BR
dc.creator.IDhttps://orcid.org/0000-0003-1322-6001pt_BR
dc.creator.Latteshttps://lattes.cnpq.br/9414806464710385pt_BR
dc.description.resumoIntrodução: O líquen plano oral (LPO) é uma doença inflamatória crônica, considerada uma desordem oral potencialmente maligna, cujos mecanismos imunológicos estão associados a seu desenvolvimento. Acredita-se que a patogênese do LPO esteja relacionada a um intenso infiltrado inflamatório subepitelial, que desempenha um papel importante na lesão sofrida pelo tecido epitelial. A inflamação crônica tem sido ainda fortemente associada à malignização dessa condição. Objetivo: Verificar a associação entre a severidade do infiltrado inflamatório e as características epiteliais observadas nas lesões de LPO. Materiais e métodos: Trata-se de um estudo transversal retrospectivo, cuja amostra contemplou um total de 41 secções histológicas de LPO coradas com Hematoxilina-Eosina, pertencentes aos Laboratórios de Patologia Oral de duas instituições de ensino superior da Bahia. Análises histológicas foram realizadas com o auxílio de um microscópio óptico de luz, em objetivas de 10x e 40x. Os aspectos morfológicos avaliados foram: presença e contagem dos corpos de Civatte, exocitose linfocítica, degeneração da camada basal e grau de inflamação do tecido. Resultados: Na amostra estudada, houve prevalência de grau severo de inflamação do tecido (85,4%). As prevalências de exocitose, degeneração da camada basal e de corpos de Civatte foram de 72,5%, 82,9% e 76,3%, respectivamente. Não houve associação significativa entre o grau de inflamação do tecido e a presença de exocitose, a degeneração da camada basal e os corpos de Civatte (p>0,05). Não se observou diferença significativa na quantidade de corpos de Civatte entre os diferentes graus de inflamação (p>0,05), e não houve associação significativa entre a presença de exocitose e a presença de degeneração da camada basal e de corpos de Civatte (p>0,05). A quantidade de corpos de Civatte não diferiu significativamente entre as amostras com ausência ou presença de exocitose (p>0,05). Conclusão: Neste estudo, não foram encontradas associações significativas entre a severidade do infiltrado inflamatório subepitelial e as características analisadas no tecido epitelial dos casos de LPO.pt_BR
dc.publisher.departmentInstituto de Ciências da Saúde - ICSpt_BR
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