Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/39035
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dc.creatorLima, Sarah Souza-
dc.date.accessioned2024-02-19T14:11:42Z-
dc.date.available2024-02-19T14:11:42Z-
dc.date.issued2023-12-15-
dc.identifier.citationLIMA, Sarah Souza. Influência da ozonioterapia sobre o infiltrado inflamatório monomorfonuclear e mastócitos no reparo tecidual cutâneo - estudo experimental in vivo. 2023. 65 f. Dissertação (Mestrado) - Universidade Federal da Bahia, Instituto de Ciências da Saúde, Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Salvador, 2023.pt_BR
dc.identifier.urihttps://repositorio.ufba.br/handle/ri/39035-
dc.description.abstractTissue repair is a complex event requiring different cell mobilization to restore the injured tissue. Ozone therapy has been used to contribute to faster resolution of the repair. The objective of the present study was to analyze the effects of ozone, as gas and as ozonated oil, on the characterization of the monomorphonuclear inflammatory infiltrate and mast cells. This was an in vivo experimental study in which Wistar rats were subjected to ozone therapy as a therapeutic approach for a standardized skin wound. The specimens were randomly allocated into three experimental groups: Control (CG), treated with ozone gas (GGO), and treated with Ozonated Oil (GOO) after cutaneous surgery, for three consecutive days. The animals were sacrificed on the 5th and 10th days. Histomorphometric analysis was performed on tissue sections stained with HE and Toluidine Blue, for semiquantitative analysis of the monomorphonuclear inflammatory infiltrate and histomorphometric analysis of mast cells, respectively. It was observed that there was no statistically significant difference regarding monomorphonuclear inflammatory infiltrate between the groups in both study periods (p>0.05). There was an increase in the number of intact and degranulated mast cells in the treated groups in comparison to the control (GGO P=0.0003; GOO p=0.004). The results confirm the participation of mast cells in the late stages of repair, thus suggesting an apparent modulation of the functional activity of these cells.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal da Bahiapt_BR
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectCicatrizaçãopt_BR
dc.subjectInflamaçãopt_BR
dc.subjectOzôniopt_BR
dc.subjectMastócitospt_BR
dc.subject.otherWound Healingpt_BR
dc.subject.otherInflammationpt_BR
dc.subject.otherOzonept_BR
dc.subject.otherMast Cellspt_BR
dc.titleInfluência da ozonioterapia sobre o infiltrado inflamatório monomorfonuclear e mastócitos no reparo tecidual cutâneo - estudo experimental in vivopt_BR
dc.title.alternativeInfluence of ozone therapy on the infiltrate monomorphonuclear inflammatory and mast cells in repair skin tissue - in vivo experimental studypt_BR
dc.typeDissertaçãopt_BR
dc.publisher.programPrograma de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas (PPGORGSISTEM) pt_BR
dc.publisher.initialsUFBApt_BR
dc.publisher.countryBrasilpt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.contributor.advisor1Medrado, Alena Ribeiro Alves Peixoto-
dc.contributor.advisor1IDhttps://orcid.org/0000-0003-4074-4680pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/5438084603507436pt_BR
dc.contributor.referee1Medrado, Alena Ribeiro Alves Peixoto-
dc.contributor.referee1IDhttps://orcid.org/0000-0003-4074-4680pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/5438084603507436pt_BR
dc.contributor.referee2Martins, Gabriela Botelho-
dc.contributor.referee2IDhttps://orcid.org/0000-0002-0917-4598pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/0714029268066739pt_BR
dc.contributor.referee3Ramos, Tércio Carneiro-
dc.contributor.referee3Latteshttp://lattes.cnpq.br/1042029457990187pt_BR
dc.creator.IDhttps://orcid.org/0000-0001-5217-342Xpt_BR
dc.creator.Latteshttp://lattes.cnpq.br/0403691995718433pt_BR
dc.description.resumoO reparo é um evento complexo que exige mobilização de diferentes células a fim de restaurar o tecido lesionado. A ozonioterapia tem sido utilizada a fim de contribuir para a resolução mais rápida do reparo. O objetivo do presente estudo foi analisar os efeitos do ozônio, sob a forma de gás e óleo, na caracterização do infiltrado inflamatório monomorfonuclear e quantitativo de mastócitos. Tratou-se de um estudo experimental in vivo no qual Ratos Wistar foram submetidos à ozonioterapia como abordagem terapêutica para um ferimento cutâneo padronizado. Os espécimes foram alocados randomicamente em três grupos experimentais: Controle (GC), tratado com Gás ozônio (GGO) e tratado com Óleo Ozonizado (GOO) após a cirurgia cutânea, por três dias consecutivos. Os animais foram sacrificados nos 5o e 10o dias. Foi realizada análise histomorfométrica em secções teciduais coradas com HE e Azul de Toluidina, para análise semiquantitativa do infiltrado inflamatório monomorfonuclear e histomorfométrica dos mastócitos, respectivamente. Foi observado que não houve diferença estatisticamente significativa no tocante ao infiltrado inflamatório monomorfonuclear entre os grupos em ambos os períodos do estudo (p>0,05). Houve crescente aumento do número de mastócitos, intactos e desgranulados nos grupos tratados em relação ao controle (GGO P=0,0003; GOO p=0,004). Os resultados apresentados ratificam que embora a ozonioterapia não tenha modulado o infiltrado inflamatório monomorfonuclear nos períodos avaliados, influenciou a participação dos mastócitos em atapas mais tardias do reparo, sugerindo assim uma aparente modulação da atividade funcional destas células.pt_BR
dc.publisher.departmentInstituto de Ciências da Saúde - ICSpt_BR
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