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https://repositorio.ufba.br/handle/ri/2877
Tipo: | Artigo de Periódico |
Título: | Outcome of children hospitalized with community-acquired pneumonia treated with aqueous penicillin G |
Título(s) alternativo(s): | Clinics |
Autor(es): | Simbalista, Raquel Araújo, Marcelo Carvalho, Cristiana Maria Costa Nascimento de |
Autor(es): | Simbalista, Raquel Araújo, Marcelo Carvalho, Cristiana Maria Costa Nascimento de |
Abstract: | OBJECTIVE: To describe the evolution and outcome of children hospitalized with community-acquired pneumonia receiving penicillin. METHODS: A search was carried out for all hospitalized community-acquired pneumonia cases in a 37-month period. Inclusion criteria comprised age >2 months, intravenous penicillin G use at 200,000 IU/kg/day for >48 h and chest x-ray results. Confounders leading to exclusion included underlying debilitating or chronic pulmonary illnesses, nosocomial pneumonia or transference to another hospital. Pneumonia was confirmed if a pulmonary infiltrate or pleural effusion was described by an independent radiologist blind to the clinical information. Data on admission and evolution were entered on a standardized form. RESULTS: Of 154 studied cases, 123 (80%) and 40 (26%) had pulmonary infiltrate or pleural effusion, respectively. Penicilli was substituted by other antibiotics in 28 (18%) patients, in whom the sole significant decrease was in the frequency of tachypnea from the first to the second day of treatment (86% vs. 50%, p = 0.008). Among patients treated exclusively with penicillin G, fever (46% vs. 26%, p = 0.002), tachypnea (74% vs. 59%, p = 0.003), chest indrawing (29% vs. 13%, p<0.001) and nasal flaring (10% vs. 1.6%, p = 0.001) frequencies significantly decreased from admission to the first day of treatment. Patients treated with other antimicrobial agents stayed longer in the hospital than those treated solely with penicillin G (16±6 vs. 8±4 days, p<0.001, mean difference (95% confidence interval) 8 (6–10)). None of the studied patients died. CONCLUSION: Penicillin G successf |
Palavras-chave: | Acute respiratory infection Antibiotic Beta-lactams Lower respiratory tract infection Treatment success |
Editora / Evento / Instituição: | Faculdade de Medicina / USP |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/2877 |
Data do documento: | 2011 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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