Please use this identifier to cite or link to this item:
metadata.dc.type: Artigo de Periódico
Title: Renal involvement in prolonged salmonella bacteremia: the role of schistosomal glomerulopathy
Other Titles: Revista do Instituto de Medicina Tropical de São Paulo
Authors: Martinelli, Reinaldo
Pereira, Luis Jose Cardoso
Brito, Edilson
Rocha, Heonir
metadata.dc.creator: Martinelli, Reinaldo
Pereira, Luis Jose Cardoso
Brito, Edilson
Rocha, Heonir
Abstract: Renal involvement has been well documented in patients with hepatosplenic schistosomiasis and in patients with prolonged salmonella bacteremia (PSB). Whether there is a specific renal lesion related to PSB or the chronic bacterial infection aggravates a pre-existing schistosomal glomerulopathy has been a matter of controversy. To analyze the clinical manifestations and histopathological findings of the renal involvement, 8 patients with hepatosplenic schistosomiasis and PSB (group I) were compared with 8 patients with schistosomal glomerulopathy (group II) matched by sex and glomerular disease. The mean age in group I was 17.7 years. All patients presented with hematuria, in 4 cases associated with non-nephrotic proteinuria. In group II the mean age was 23 years; nephrotic syndrome was the clinical presentation in 7 of the 8 patients in the group. All patients in group I experienced remission of the clinical and laboratory abnormalities as the salmonella infection was cured; in group II the patients had persistent, steroid-resistant, nephrotic syndrome. On histological examination, no difference was noted between the two groups, except for pronounced glomerular hypercellularity and interstitial mononuclear cell infiltration in group I. These observations strongly suggest that PSB exacerbates a pre-existing sub-clinical schistosomal glomerulopathy by the addition of active lesions directly related to the prolonged bacteremia.
Keywords: Schistosomiasis mansoni
Prolonged salmonella bacteremia
Clinical manifestations
Issue Date: 1992
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

Files in This Item:
File Description SizeFormat 
a02v34n3.pdf584,59 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.