Campo DC | Valor | Idioma |
dc.contributor.author | Araujo, Maria Ilma Andrade Santos | - |
dc.contributor.author | Hoppe, Bradford | - |
dc.contributor.author | Medeiros Junior, Manoel | - |
dc.contributor.author | Alcântara, Leda Maria | - |
dc.contributor.author | Almeida, Maria Cecilia Freitas de | - |
dc.contributor.author | Schriefer, Nicolaus Albert Borges | - |
dc.contributor.author | Oliveira, Ricardo Riccio | - |
dc.contributor.author | Kruschewsky, Ramon de Almeida | - |
dc.contributor.author | Figueiredo, Joanemile Pacheco de | - |
dc.contributor.author | Cruz Filho, Álvaro Augusto Souza da | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Araujo, Maria Ilma Andrade Santos | - |
dc.creator | Hoppe, Bradford | - |
dc.creator | Medeiros Junior, Manoel | - |
dc.creator | Alcântara, Leda Maria | - |
dc.creator | Almeida, Maria Cecilia Freitas de | - |
dc.creator | Schriefer, Nicolaus Albert Borges | - |
dc.creator | Oliveira, Ricardo Riccio | - |
dc.creator | Kruschewsky, Ramon de Almeida | - |
dc.creator | Figueiredo, Joanemile Pacheco de | - |
dc.creator | Cruz Filho, Álvaro Augusto Souza da | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2015-06-02T14:12:06Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/17845 | - |
dc.description | Texto completo: acesso restrito. p. 1797-1803 | pt_BR |
dc.description.abstract | Helminthic infections have been shown to inhibit allergy skin-prick tests and to modify the course of asthma. We evaluated Dermatophagoides pteronyssinus-specific immune responses in patients with asthma by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoni-infected patients with asthma living in an area of polyhelminthic endemicity produced lower levels of interleukin (IL)-5 and IL-4 in response to D. pteronyssinus antigen (Ag) 1 than did PBMCs from helminth-free patients with asthma. In contrast, D. pteronyssinus Ag 1-specific production of IL-10 was higher in helminth-infected patients than in helminth-free patients. The addition of recombinant human IL-10 to D. pteronyssinus Ag 1-stimulated cultures of PBMCs from helminth-free patients led to downmodulation of production of IL-5. After helminth-infected patients with asthma received antihelminthic treatment, there was down-modulation of D. pteronyssinus Ag 1-specific production of IL-10 in vitro. S. mansoni-infected patients with asthma produce lower levels of Th2 cytokines than do helminth-free patients with asthma, and this modulation is likely done by IL-10. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1086/425017 | pt_BR |
dc.subject | Asthma | pt_BR |
dc.subject | Interleukin-4 | pt_BR |
dc.subject | Interleukin-5 | pt_BR |
dc.subject | Asma | pt_BR |
dc.subject | Interleucina-4 | pt_BR |
dc.subject | Th2 Cells | pt_BR |
dc.subject | Interleucina-5 | pt_BR |
dc.subject | Células TH2 | pt_BR |
dc.title | Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma | pt_BR |
dc.title.alternative | Journal of Infectious Diseases | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 190, n. 10 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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