https://repositorio.ufba.br/handle/ri/17651
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Bahia, Fabianna Márcia Maranhão | - |
dc.contributor.author | Novais, Vinicius | - |
dc.contributor.author | Evans, Jennifer | - |
dc.contributor.author | Marchand, Chloe Le | - |
dc.contributor.author | Martins Netto, Eduardo | - |
dc.contributor.author | Page, Kimberly | - |
dc.contributor.author | Alves, Carlos Roberto Brites | - |
dc.creator | Bahia, Fabianna Márcia Maranhão | - |
dc.creator | Novais, Vinicius | - |
dc.creator | Evans, Jennifer | - |
dc.creator | Marchand, Chloe Le | - |
dc.creator | Martins Netto, Eduardo | - |
dc.creator | Page, Kimberly | - |
dc.creator | Alves, Carlos Roberto Brites | - |
dc.date.accessioned | 2015-05-11T14:35:23Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1525-4135 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/17651 | - |
dc.description | Texto completo: acesso restrito. p. 202-207 | pt_BR |
dc.description.abstract | Background: HIV, hepatitis C (HCV), and human T-cell lymphotropic virus I (HTLV-1) are associated with high global burdens of disease, notably in resource-poor locales. They share similar routes of transmission and cause chronic infections with associated morbidity. We performed a cross-sectional study to assess the impact of HTLV-1 infection on clinical outcomes in HIV/HCV-coinfected patients. Methods: We enrolled 102 (72.3%) with HIV/HCV coinfection (Group 1) and 39 (27.7%) triply infected with HIV, HCV, and HTLV-1 (Group 2). We reviewed medical records of two groups of patients followed in two outpatients services in Salvador, Brazil. We collected and compared demographic, behavioral-related information, immunologic, virologic, and histologic parameters for HIV-1 and HCV infection. Results: Demographics, virologic, and immunologic characteristics were similar in the two groups; a higher proportion of triply infected patients (Group 2) reported any history of injection drug use compared with dually infected (Group 1) patients (75% vs 45.8%; P = 0.003). No differences were seen between groups in HIV clinical outcomes (CD4 count and viral load). Alanine aminotransferase levels were significantly higher in HIV/HCV-coinfected patients (P = 0.045). Liver fibrosis damage based on Metavir scores was similar between groups (0.97) but was worse with lower CD4 cell count (under 200 cells/mm3) (P = 0.01). Conclusions: HIV/HTLV-1 and HIV/HCV coinfections may worsen clinical related outcomes, but virologic and immunologic outcomes were similar in both groups. Hepatic measures were worse in patients with more severe immunosuppression. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.1097/QAI.0b013e31821e9a1e | pt_BR |
dc.subject | HIV-1 and HCV coinfection | pt_BR |
dc.subject | HIV-1 | pt_BR |
dc.subject | HCV | pt_BR |
dc.subject | HTLV-1 triple infection | pt_BR |
dc.title | The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus | pt_BR |
dc.title.alternative | JAIDS Journal of Acquired Immune Deficiency Syndromes | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 57, Supl. 3 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
dc.publisher.country | Brasil | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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