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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/16603
Tipo: Artigo de Periódico
Título: Clinical manifestations in individuals with recent diagnosis of HTLV type I infection
Título(s) alternativo(s): Journal of Clinical Virology
Autor(es): Poetker, Shelene K. W.
Porto, Maria Aurélia da Fonseca
Giozza, Silvana P.
Muniz, André Luís Nunes
Caskey, Marina F.
Carvalho Filho, Edgar Marcelino de
Glesby, Marshall J.
Autor(es): Poetker, Shelene K. W.
Porto, Maria Aurélia da Fonseca
Giozza, Silvana P.
Muniz, André Luís Nunes
Caskey, Marina F.
Carvalho Filho, Edgar Marcelino de
Glesby, Marshall J.
Abstract: Background: Human T-lymphotropic virus type 1 (HTLV-1) is known to cause HTLV-associated myelopathy (HAM)/tropical spastic paraparesis and adult T cell leukemia. A growing body of evidence links HTLV-1 infection with an increasing spectrum of disease, including uveitis, periodontal disease, arthropathy, sicca syndrome, and neurologic deficits. Objectives: Despite recent findings, the natural history of HTLV-1 infection remains poorly defined. This study was designed to better characterize initial clinical and neurological findings in individuals diagnosed with HTLV-1 infection. Study design: We conducted a cross-sectional study of 71 individuals recently diagnosed with HTLV-1 and 71 uninfected age- and sex-matched blood donors in Salvador, Brazil. Subjects were administered a standardized questionnaire and underwent physical exam. Results: HTLV-1 infected subjects were significantly more likely than controls to report complaints of hand and foot numbness (OR = 5.3; 95% CI: 1.8–15.3; p = 0.002 and OR = 4.0; 95% CI: 1.3–12; p = 0.013 respectively), difficulty running (OR = 4.0; 95% CI: 1.1–14.2; p = 0.032), nocturia (OR = 5.0; 95% CI: 1.1–22.8; p = 0.038), arthralgia (OR = 3.3; 95% CI: 1.4–7.7; p = 0.006), and photophobia (OR = 3.3; 95% CI: 1.4–7.7; p = 0.006). Conclusions: Neurologic, ocular and rheumatologic complaints may be the first manifestations of HTLV-1 infection. Therefore, all patients presenting with initial diagnosis should be rigorously screened for these symptoms.
Palavras-chave: HTLV-1
Neurologic manifestations
Clinical manifestations
Neuropathy
Natural history
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/16603
Data do documento: 2011
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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