https://repositorio.ufba.br/handle/ri/16602
Tipo: | Artigo de Periódico |
Título: | Antibodies to schistosoma mansoni in human cerebrospinal fluid |
Título(s) alternativo(s): | American Journal of Tropical Medicine and Hygiene |
Autor(es): | Lemaire, Denise Carneiro Santos, Isis F. Magalhães Andrade Filho, Antônio de Souza Queiroz, Aristides Cheto de Carvalho, Otavio Augusto Moreno de Carmo, Theomira Mauadie Azevedo Siqueira, Isadora C. Andrade, Débora M. Rego, Michely F. Guedes, Ana Paula T. Reis, Mitermayer Galvão dos |
Autor(es): | Lemaire, Denise Carneiro Santos, Isis F. Magalhães Andrade Filho, Antônio de Souza Queiroz, Aristides Cheto de Carvalho, Otavio Augusto Moreno de Carmo, Theomira Mauadie Azevedo Siqueira, Isadora C. Andrade, Débora M. Rego, Michely F. Guedes, Ana Paula T. Reis, Mitermayer Galvão dos |
Abstract: | Cerebrospinal fluid (CSF) and serum samples from patients suspected of having neuroschistosomiasis (NS) were evaluated by an enzyme-linked immunosorbent assay. Monoclonal antibodies of various immunoglobulin isotypes (IgM, IgA, IgE, total IgG, IgG1, IgG2, IgG3, and IgG4) were used to detect antibodies against Schistosoma mansoni soluble egg antigen (SEA) and soluble worm adult preparation (SWAP). Of the 83 CSF samples tested, 55% were reactive toSEA (26% were reactive only toSEA and 29% tobo th SEA and SWAP), 34% were reactive toSWAP (5% only to SWAP and 29% to both SEA and SWAP), and 40% were not reactive with any antigen. Cases that tested positive for SWAP in CSF and negative in serum were not found. Samples with high specific IgG antibody titers were selected for immunoglobulin isotype profiling. In the CSF samples, the antibodies against SEA and SWAP were mainly IgM, IgG1, and IgG4, although other immunoglobulins were also detected. Interestingly, nine patients had high levels of IgG1 only in the CSF. These results suggest that there is local synthesis of IgG1, and that this isotype could be an important immunologic marker in the diagnosis of NS. |
Palavras-chave: | Schistosoma mansoni Immunoglobulin Isotypes Neuroschistosomiasis |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16602 |
Data do documento: | 2003 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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DENISE C. LEMAIRE.pdf | 136,1 kB | Adobe PDF | Visualizar/Abrir |
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