Campo DC | Valor | Idioma |
dc.contributor.author | Lima, Luciane Mota | - |
dc.contributor.author | Santos, Silvane Maria Braga | - |
dc.contributor.author | Oliveira, Ricardo Riccio | - |
dc.contributor.author | Cardoso, Luciana Santos | - |
dc.contributor.author | Oliveira, Sérgio Costa | - |
dc.contributor.author | Góes, Alfredo Miranda | - |
dc.contributor.author | Loukas, Alex | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Araujo, Maria Ilma Andrade Santos | - |
dc.creator | Lima, Luciane Mota | - |
dc.creator | Santos, Silvane Maria Braga | - |
dc.creator | Oliveira, Ricardo Riccio | - |
dc.creator | Cardoso, Luciana Santos | - |
dc.creator | Oliveira, Sérgio Costa | - |
dc.creator | Góes, Alfredo Miranda | - |
dc.creator | Loukas, Alex | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Araujo, Maria Ilma Andrade Santos | - |
dc.date.accessioned | 2014-11-11T17:49:58Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1021-740 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16544 | - |
dc.description | Texto completo: acesso restrito. p. 233-238 | pt_BR |
dc.description.abstract | Human T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the immune response to HTLV-1 infection is polarized to the Th1-type, chronic helminth infections drive the Th2- and T regulatory-type, and are able to downregulate the inflammatory response in some autoimmune diseases. Objective: To evaluate whether Schistosoma spp. antigens alter the in vitro cytokine response in HTLV-1 infection. Methods: The recombinant Schistosoma antigens Sm29 and ShTSP2 (tetraspanin) and PIII, a fraction of the Schistosoma mansoni adult worm antigen were added to peripheral blood mononuclear cell (PBMC) cultures of HTLV-1-infected individuals and the levels of interferon (IFN)-γ and interleukin (IL)-10 in the supernatants were measured using the ELISA sandwich technique. Results: Compared to the levels of cytokine in nonstimulated cultures, the levels of IFN-γ were reduced in 50, 47 and 50% of patients by the presence of Sm29, ShTsp2 and PIII, respectively. The downregulation of IFN-γ production in the presence of Sm29 antigen was observed mainly in subjects who had lower basal levels of this cytokine. The levels of IL-10, however, increased by the addition of the three antigens in the cultures in 74, 62 and 44% of individuals, respectively. In addition, there was a decrease in the ratio of IFN-γ/IL-10 levels in cultures stimulated with Sm29 and ShTSP2 when compared to nonstimulated ones. Conclusions: The Schistosoma spp. antigens used in this study were able to downmodulate IFN-γ production in vitro in HTLV-1 infection. This may be associated with the increased levels of IL-10 induced by the antigens. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1159/000348700 | pt_BR |
dc.subject | Human T cell lymphotropic virus type 1 | pt_BR |
dc.subject | Schistosoma spp. antigens | pt_BR |
dc.subject | Interferon-γ | pt_BR |
dc.subject | Interleukin-10
| pt_BR |
dc.title | Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 | pt_BR |
dc.title.alternative | Neuroimmunomodulation | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 20, n. 4 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (FAR)
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