Skip navigation
Universidade Federal da Bahia |
Repositório Institucional da UFBA
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/16397
Tipo: Artigo de Periódico
Título: Towards a more precise serological diagnosis of human Tegumentary Leishmaniasis using Leishmania Recombinant Proteins
Título(s) alternativo(s): PLoS ONE
Autor(es): Souza, Ana Paula Almeida de
Soto, Manuel
Costa, Jackson M. L.
Boaventura, Viviane Sampaio
Oliveira, Camila Indiani de
Cristal, Juqueline Rocha
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Autor(es): Souza, Ana Paula Almeida de
Soto, Manuel
Costa, Jackson M. L.
Boaventura, Viviane Sampaio
Oliveira, Camila Indiani de
Cristal, Juqueline Rocha
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Abstract: Exposure to Leishmania induces a humoral immune response that can be used as a marker of parasite exposure. Methodology/Principal Findings: Herein, ELISA was used to screen sera from patients with Tegumentary Leishmaniasis (TL) against different L. infantum-chagasi-derived recombinant proteins (rHSP70, rH2A, rH2B, rH3, rH4 and rKMP11). Among the recombinant proteins, rHSP70 and rH2A showed the best reactivity against human sera obtained from endemic areas of TL. Receiver-Operator Characteristics (ROC) curve analysis was used to identify the effectiveness of these proteins for serodiagnosis of TL. ROC curves confirmed the superior performance of rHSP70 and rH2A, in comparison to the other tested recombinant proteins. Additionally, we evaluated the specificity of the response to rHSP70 and rH2A by testing sera obtained from patients with Chagas' disease, Tuberculosis, Leprosy or Systemic Lupus Erythematosus. In this case, rHSP70 displayed an increased ability to discriminate diseases, in comparison to SLA. Conclusion: Our results raise possibility of using rHSP70 for the serodiagnosis of TL
País: Brasil
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/16397
Data do documento: 2013
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
journal.pone.0066110.pdf2,14 MBAdobe PDFVisualizar/Abrir
Mostrar registro completo do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.