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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/16390
Tipo: Artigo de Periódico
Título: Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats
Título(s) alternativo(s): Journal of Cardiovascular Pharmacology
Autor(es): Veras, Robson Cavalcante
Rodrigues, Karoline Gomes
Fernandes, Maria do Carmo de Alustau
Gonçalves, Islania Giselia Albuquerque
Barros, André Luis Branco de
Alves, Ricardo José
Nakao, Lia Sumie
Braga, Valdir de Andrade
Vasconcelos, Darizy Flavia Silva Amorim de
Medeiros, Isac Almeida de
Autor(es): Veras, Robson Cavalcante
Rodrigues, Karoline Gomes
Fernandes, Maria do Carmo de Alustau
Gonçalves, Islania Giselia Albuquerque
Barros, André Luis Branco de
Alves, Ricardo José
Nakao, Lia Sumie
Braga, Valdir de Andrade
Vasconcelos, Darizy Flavia Silva Amorim de
Medeiros, Isac Almeida de
Abstract: For many years, nitric oxide (NO) has been studied as an important mediator in the control of vascular tone. Endothelial deficiencies that diminish NO production can result in the development of several future cardiovascular diseases, such as hypertension and arteriosclerosis. In this context, new drugs with potential ability to donate NO have been studied. In this study, 3 aromatic oximes [benzophenone oxime, 4-Cl-benzophenone oxime, and E-cinnamaldehyde oxime (E-CAOx)] induced vasorelaxation in endothelium-denuded and intact superior mesenteric rings precontracted with phenylephrine. E-CAOx demonstrated the most potent effect, and its mechanism of action was evaluated. Vascular reactivity experiments demonstrated that the effect of E-CAOx was reduced by the presence of 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, 1H[1,2,4,]oxadiazolo[4,3-a]quinoxalin-1-one, and (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate, suggesting the participation of NO/sGC/PKG pathway. NO donation seems to be mediated through nicatinamide adenine dinucleotide phosphate-dependent reductases because 7-ethoxyresorufin decreased the effect of E-CAOx on vascular reactivity and reduced NO formation as detected by flow cytometry using the NO indicator diaminofluorescein 4,5-diacetate. Further downstream of NO donation, K+ subtype channels were also shown to be involved in the E-CAOx vasorelaxant effect. The present study showed that E-CAOx acts like an NO donor, activating NO/sGC/PKG pathway and thus K+ channels.
Palavras-chave: Endothelium
NO donor
Oxime
Rat
Vasorelaxation
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/16390
Data do documento: 2013
Aparece nas coleções:Artigo Publicado em Periódico (FAR)

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