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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/16370
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dc.contributor.authorOliveira, Marília Gerhardt de-
dc.contributor.authorRamalho, Luciana Maria Pedreira-
dc.contributor.authorMelo, Lêonilson Gaião de-
dc.contributor.authorPozza, Daniel Humberto-
dc.contributor.authorMello, Ramon Andrade de-
dc.creatorOliveira, Marília Gerhardt de-
dc.creatorRamalho, Luciana Maria Pedreira-
dc.creatorMelo, Lêonilson Gaião de-
dc.creatorPozza, Daniel Humberto-
dc.creatorMello, Ramon Andrade de-
dc.date.accessioned2014-10-10T14:25:37Z-
dc.date.issued2012-
dc.identifier.issn1791-2997-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/16370-
dc.descriptionTexto completo: acesso restrito. p. 163-166pt_BR
dc.description.abstractThe retinoblastoma (Rb) and p53 genes play a fundamental role in cell cycle mechanisms, and their deregulation is related to many steps of oral cancer carcinogenesis. This study was conducted to evaluate the expression of the p53 and Rb proteins in malignant and pre-malignant oral cavity lesions. This retrospective study was conducted at the Federal University of Bahia, Salvador, Brazil, and the Molecular Biology Laboratory of the Otorhinolaryngology Department at the University of Heidelberg, Heidelberg, Germany. Excisional biopsy samples of oral cavities were collected from patients with suspected oral lesions. The samples were processed by immunohistochemistry to be classified by a semi-quantitative score: samples with a ≤10% positivity were considered to have weak/negative expression (-); those with 11-50% positivity, moderate expression (+); and those with >50% positivity, high expression (++). Seventy-one patients were studied (75% male; median age, 52 years; range, 24-84). Of the samples studied, 59.4% were oral squamous cell carcinoma (OSCC) and 40.6% were pre-neoplastic lesions (leukoplakia and actinic cheilitis). OSCC presented higher expression of Rb protein compared to pre-malignant lesions: 75 vs. 25% (p<0.001). Pre-neoplastic lesions presented higher expression of p53 protein compared to OSCC lesions: 55.2 vs. 44.8% (p=0.030). Despite the small number of samples, the expression of these cell cycle biomarkers (p53 and Rb protein) in excisional biopsies suggests that molecular lesion assessment can determine pre-malignant lesions, and that its use may improve the clinical and surgical treatment of early lesions. Thus, p53 protein expression may be related to the early steps of carcinogenesis in OSCC. Finally, a higher Rb expression was also observed in malignant lesions.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/10.3892/mmr.2012.876pt_BR
dc.titleRetinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinomapt_BR
dc.title.alternativeMolecular Medicine Reportspt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 6, n. 1pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Odontologia)

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