Campo DC | Valor | Idioma |
dc.contributor.author | Oliveira, Lucivalda P. M. | - |
dc.contributor.author | Jesus, Rosangela P. de | - |
dc.contributor.author | Boulhosa, Ramona Souza da Silva Baqueiro | - |
dc.contributor.author | Mendes, Carlos Maurício Cardeal | - |
dc.contributor.author | Gnoatto, Maria Cecilia | - |
dc.contributor.author | Lemaire, Denise Carneiro | - |
dc.contributor.author | Toralles, Maria Betânia Pereira | - |
dc.contributor.author | Cavalcante, Lourianne N. | - |
dc.contributor.author | Lyra, André Castro | - |
dc.contributor.author | Lyra, Luiz Guilherme Costa | pt_BR |
dc.creator | Oliveira, Lucivalda P. M. | - |
dc.creator | Jesus, Rosangela P. de | - |
dc.creator | Boulhosa, Ramona Souza da Silva Baqueiro | - |
dc.creator | Mendes, Carlos Maurício Cardeal | - |
dc.creator | Gnoatto, Maria Cecilia | - |
dc.creator | Lemaire, Denise Carneiro | - |
dc.creator | Toralles, Maria Betânia Pereira | - |
dc.creator | Cavalcante, Lourianne N. | - |
dc.creator | Lyra, André Castro | - |
dc.creator | Lyra, Luiz Guilherme Costa | - |
dc.date.accessioned | 2014-10-09T15:50:35Z | - |
dc.date.available | 2014-10-09T15:50:35Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16362 | - |
dc.description | p. 2203-2211 | pt_BR |
dc.description.abstract | AIM: To evaluate the effects of soy supplementation on insulin resistance, fatty liver and alanine aminotransferase (ALT) levels in non-diabetic patients with chronic hepatitis C (CHC). METHODS: In a prospective, randomized and single-blinded clinical trial, we compared patients with CHC who had casein as a supplement (n = 80) (control group), with patients who consumed a soy supplement diet (n = 80) [intervention group (IG)]. Both groups received 32 g/d of protein for 12 wk. RESULTS: Patients’ baseline features showed that 48.1% were overweight, 43.7% had abdominal fat accumulation, 34.7% had hepatic steatosis and 36.3% had an homeostasis model assessment index of insulin resistance (HOMA-IR) ≥ 3.0. Descriptive analysis showed that protein supplementation diet reduced hepatic steatosis in both groups; however, significant reductions in ALT levels occurred in the soy group. Multiple regression modeling indicated that in the presence of severe fibrosis (F3/F4), γ glutamyl transferase elevation and high density lipoprotein (HDL) reduction, the intervention group had 75% less chance of developing hepatic steatosis (OR= 0.25; 95% CI: 0.06-0.82) and 55% less chance of presenting with an ALT level ≥ 1.5 × the upper limit of normal (ULN) (OR = 0.45, 95% CI: 0.22-0.89). Soy treatment did not have any effect on insulin resistance (OR = 1.92; 95% CI: 0.80-4.83), which might be attributed to the fact that the HOMA-IR values at baseline in most of our patients were in the normal range. Advanced hepatic fibrosis, an ALT level > 1.5 × ULN and visceral fat were predictors of an HOMA-IR ≥ 3. The IG group had a reduced risk of an ALT level > 1.5 × ULN. An HOMA-IR ≥ 3.0 and HDL < 35 mg/dL were also risk factors for increased ALT. CONCLUSION: Soy supplementation decreased ALT levels and thus may improve liver inflammation in hepatitis C virus (HCV) patients; it also reduced hepatic steatosis in a subgroup of patients but did not change insulin resistance. It should be considered in the nutritional care of HCV patients. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.3748/wjg.v18.i18.2203 | pt_BR |
dc.subject | Chronic hepatitis C | pt_BR |
dc.subject | Soy supplementation | pt_BR |
dc.subject | Insulin resistance | pt_BR |
dc.subject | Hepatic steatosis | pt_BR |
dc.subject | Hepatitis C virus | pt_BR |
dc.title | Effect of soy protein supplementation in patients with chronic hepatitis C: A randomized clinical trial | pt_BR |
dc.title.alternative | World Journal of Gastroenterology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 18, n. 18 | pt_BR |
dc.publisher.country | Brasil | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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