Campo DC | Valor | Idioma |
dc.contributor.author | Sundberg, Michael A. | - |
dc.contributor.author | Costa, Davi | - |
dc.contributor.author | Orge, Gloria | - |
dc.contributor.author | Castro, Néviton Matos de | - |
dc.contributor.author | Muniz, André Luís Nunes | - |
dc.contributor.author | Glesby, Marshall J. | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Sundberg, Michael A. | - |
dc.creator | Costa, Davi | - |
dc.creator | Orge, Gloria | - |
dc.creator | Castro, Néviton Matos de | - |
dc.creator | Muniz, André Luís Nunes | - |
dc.creator | Glesby, Marshall J. | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2014-09-23T13:56:37Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1386-6532 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16145 | - |
dc.description | Texto completo: acesso restrito. p. 251–255 | pt_BR |
dc.description.abstract | Background Infection with the human T-cell lymphotropic virus, type 1 (HTLV-1) has been associated with an increased Th1 response. Interestingly, a higher prevalence of helminthic coinfection has been observed among infected individuals, and subsequent modulation of the immune response typically associated with helminths may influence clinical outcomes among HTLV-1 coinfected individuals. Objective This study was conducted to elucidate the association between helminthic coinfection and the development of clinically characterized neurologic disease that occurs in HTLV-1 infection. Study design In a cohort analysis, incidence of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was recorded. Incidence of clinical outcomes and disease-free survival of several neurologic outcomes associated with HTLV-1 were estimated using the Kaplan–Meier method with log-rank tests. The relationships between helminthic infection and risk of HTLV-1 neurologic outcomes were assessed by Cox proportional hazard modeling.
Results Seventy-four coinfected and 79 non-coinfected patients were followed, with 92 helminthic infections observed in the coinfected group. One patient per group developed HAM/TSP and the risk of progression to neurologic disease outcomes did not differ among those with and without helminthic coinfection (p > 0.45). A significant difference was noted in the prevalence of neurologic disease outcomes among all patients at the conclusion of the study (p < 0.01). Conclusions These data suggest that treated helminthic infection does not affect risk of development of neurologic disease in HTLV-1 infection, and reinforce that treatment of helminths does not adversely affect patients with HTLV-1. Importantly, among all patients, an overall progression of neurologic disease was observed. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.1016/j.jcv.2011.12.018 | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | HAM/TSP | pt_BR |
dc.subject | Neurologic disease | pt_BR |
dc.subject | Helminths | pt_BR |
dc.subject | Survival analysis | pt_BR |
dc.title | Helminthic infection and the risk of neurologic disease progression in HTLV-1 | pt_BR |
dc.title.alternative | Journal of Clinical Virology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 53, n. 3 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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