Campo DC | Valor | Idioma |
dc.contributor.author | Carvalho, Lain Carlos Pontes de | - |
dc.contributor.author | Passos, S. | - |
dc.contributor.author | Bacellar, Maria Olívia Amado Ramos | - |
dc.contributor.author | Lessa, M. | - |
dc.contributor.author | Almeida, Roque Pacheco de | - |
dc.contributor.author | Magalhães, A. | - |
dc.contributor.author | Dutra, Walderez Ornelas | - |
dc.contributor.author | Jesus, A. Ribeiro de | - |
dc.contributor.author | Gollob, K. J. | - |
dc.contributor.author | Machado, Paulo Roberto Lima | - |
dc.creator | Carvalho, Lain Carlos Pontes de | - |
dc.creator | Passos, S. | - |
dc.creator | Bacellar, Maria Olívia Amado Ramos | - |
dc.creator | Lessa, M. | - |
dc.creator | Almeida, Roque Pacheco de | - |
dc.creator | Magalhães, A. | - |
dc.creator | Dutra, Walderez Ornelas | - |
dc.creator | Jesus, A. Ribeiro de | - |
dc.creator | Gollob, K. J. | - |
dc.creator | Machado, Paulo Roberto Lima | - |
dc.date.accessioned | 2014-09-09T16:14:33Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0141-9838 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16012 | - |
dc.description | Texto completo: acesso restrito. p. 251-258 | pt_BR |
dc.description.abstract | Cutaneous (CL) and mucosal leishmaniasis (ML) are characterized by a predominant type 1 immune response (IFN-γ and TNF-α production) and strong inflammatory response in the lesions with few parasites. This exacerbated type 1 response is more evident in ML as compared to CL. Our main hypothesis is that a differential immune regulation of T cell activation leads to over reactive T cells in ML. In the present study, we investigated immunological factors that could explain the mechanisms behind it by comparing some immune regulatory mechanisms between ML and CL patients: frequency of cells expressing co-stimulatory molecules, apoptotic markers, T cell activation markers; and ability of neutralizing antibodies to IL-2, IL-12 and IL-15 do down-regulate IFN-γ production in leishmania antigen-stimulated peripheral blood mononuclear cells (PBMC). Interestingly, in CL anti-IL-2 and anti-IL-15 significantly suppressed antigen-specific IFN-γ production, while in ML only anti-IL-2 suppressed IFN-γ production. Finally, higher frequency of CD4+ T cells expressing CD28−, CD69+ and CD62Llow were observed in ML as compared to CL. These data indicate that an exacerbated type 1 response in ML is differentially regulated and not appropriately down modulated, with increased frequencies of activated effectors T cells, maintaining the persistent inflammatory response and tissue damage observed in ML. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1111/j.1365-3024.2007.00940.x | pt_BR |
dc.subject | Activated T cells | pt_BR |
dc.subject | Cutaneous leishmaniasis | pt_BR |
dc.subject | Cytokines | pt_BR |
dc.subject | Human leishmaniasis | pt_BR |
dc.subject | Mucosal leishmaniasis | pt_BR |
dc.title | Differential immune regulation of activated T cells between cutaneous and mucosal leishmaniasis as a model for pathogenesis | pt_BR |
dc.title.alternative | Parasite Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 29, n. 5 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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