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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/15961
Tipo: Artigo de Periódico
Título: Low frequency of the ΔF508 mutation of the CFTR gene in a highly admixed population in Bahia, Brazil
Título(s) alternativo(s): Human Biology
Autor(es): Costa, Fabiana Maia Moura
Santana, Maria Angélica Pinheiro Santos
Lemos, Antônio Carlos Moreira
Acosta, Angelina Xavier
Autor(es): Costa, Fabiana Maia Moura
Santana, Maria Angélica Pinheiro Santos
Lemos, Antônio Carlos Moreira
Acosta, Angelina Xavier
Abstract: Cystic fibrosis (CF) is the most common autosomal recessive disease in the European (Caucasian) population, with an incidence of 1:2,000 to 1:8,000. The F508 mutation (66%) is predominant among more than 1,300 different mutations of the CFTR gene. The population of the state of Bahia, in northeastern Brazil, is highly admixed (mainly African and Portuguese descendants), and so far, no study has been carried out to assess the molecular basis of CF in this population.We determined the F508 mutation frequency in 503 individuals from the general population of Salvador, the capital of the state of Bahia, and in 144 CF patients from several cities in Bahia. In the general population samples we found 4 individuals heterozygous for the F508 mutation (allele frequency of 0.4%). This frequency was lower than that found in the state of Rio de Janeiro, in southeastern Brazil, and similar to that reported for the state of Paraná, in the far south. In the CF patients we found 9 heterozygous individuals and 8 homozygous individuals (allele frequency of 8.68%) for the F508 mutation. This frequency is considerably lower than the average frequency of CF in the world population and in the Brazilian CF population of European ancestry (47%). These data could be explained by the intense admixture among the population in Bahia, and they suggest a heterogeneous molecular basis for CF in this area of Brazil.
Palavras-chave: Cystic fibrosis
F508 mutation
CFTR gene
Population genetics
Brasil
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/15961
Data do documento: 2007
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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