Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/15737
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dc.contributor.authorRossi, Andre L.-
dc.contributor.authorBarreto, Isabela Cerqueira-
dc.contributor.authorMaciel, William Q.-
dc.contributor.authorRosa, Fabiana Paim-
dc.contributor.authorLeão, Maria H. Rocha-
dc.contributor.authorWerckmann, Jacques-
dc.contributor.authorRossi, Alexandre Malta-
dc.contributor.authorBorojevic, Radovan-
dc.contributor.authorFarina, Marcos-
dc.creatorRossi, Andre L.-
dc.creatorBarreto, Isabela Cerqueira-
dc.creatorMaciel, William Q.-
dc.creatorRosa, Fabiana Paim-
dc.creatorLeão, Maria H. Rocha-
dc.creatorWerckmann, Jacques-
dc.creatorRossi, Alexandre Malta-
dc.creatorBorojevic, Radovan-
dc.creatorFarina, Marcos-
dc.date.accessioned2014-08-28T21:31:27Z-
dc.date.issued2012-
dc.identifier.issn8756-3282-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/15737-
dc.descriptionTexto completo: acesso restrito. p. 301–310pt_BR
dc.description.abstractWe report the ultrastructure of regenerated bone surrounding two types of biomaterials: hydroxyapatite–alginate composite and sintered hydroxyapatite. Critical defects in the calvaria of Wistar rats were filled with micrometer-sized spherical biomaterials and analyzed after 90 and 120 days of implantation by high-resolution transmission electron microscopy and Fourier transform infrared attenuated total reflectance microscopy, respectively. Infrared spectroscopy showed that hydroxyapatite of both biomaterials became more disordered after implantation in the rat calvaria, indicating that the biological environment induced modifications in biomaterials structure. We observed that the regenerated bone surrounding both biomaterials had a lamellar structure with type I collagen fibers alternating in adjacent lamella with angles of approximately 90°. In each lamella, plate-like apatite crystals were aligned in the c-axis direction, although a rotation around the c-axis could be present. Bone plate-like crystal dimensions were similar in regenerated bone around biomaterials and pre-existing bone in the rat calvaria. No epitaxial growth was observed around any of the biomaterials. A distinct mineralized layer was observed between new bone and hydroxyapatite–alginate biomaterial. This region presented a particular ultrastructure with crystallites smaller than those of the bulk of the biomaterial, and was possibly formed during the synthesis of alginate-containing composite or in the biological environment after implantation. Round nanoparticles were observed in regions of newly formed bone. The findings of this work contribute to a better understanding of the role of hydroxyapatite based biomaterials in bone regeneration processes at the nanoscale.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/ 10.1016/j.bone.2011.10.022pt_BR
dc.subjectBone implantpt_BR
dc.subjectHydroxyapatite–alginate compositept_BR
dc.subjectBone ultrastructurept_BR
dc.subjectBiomaterialspt_BR
dc.subjectBiomineralizationpt_BR
dc.subjectHRTEMpt_BR
dc.titleUltrastructure of regenerated bone mineral surrounding hydroxyapatite–alginate composite and sintered hydroxyapatitept_BR
dc.title.alternativeBonept_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 50, n. 1pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (ICS)

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