Campo DC | Valor | Idioma |
dc.contributor.author | Bastos, Maria de Lourdes Santos | - |
dc.contributor.author | Santos, Silvane Maria Braga | - |
dc.contributor.author | Souza, Anselmo de Santana | - |
dc.contributor.author | Finkmoore, Brooke | - |
dc.contributor.author | Bispo, Ohana | - |
dc.contributor.author | Barreto, Tasso | - |
dc.contributor.author | Cardoso, Ingrid | - |
dc.contributor.author | Bispo, Iana | - |
dc.contributor.author | Bastos, Flávia | - |
dc.contributor.author | Pereira, Daniele | - |
dc.contributor.author | Riley, Lee | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Bastos, Maria de Lourdes Santos | - |
dc.creator | Santos, Silvane Maria Braga | - |
dc.creator | Souza, Anselmo de Santana | - |
dc.creator | Finkmoore, Brooke | - |
dc.creator | Bispo, Ohana | - |
dc.creator | Barreto, Tasso | - |
dc.creator | Cardoso, Ingrid | - |
dc.creator | Bispo, Iana | - |
dc.creator | Bastos, Flávia | - |
dc.creator | Pereira, Daniele | - |
dc.creator | Riley, Lee | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2014-08-07T13:25:03Z | - |
dc.date.available | 2014-08-07T13:25:03Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/15504 | - |
dc.description | p. 1-8 | pt_BR |
dc.description.abstract | Background HTLV-1 is associated with increased susceptibility to Mycobacterium tuberculosis infection and severity of tuberculosis. Although previous studies have shown that HTLV-1 infected individuals have a low frequency of positive tuberculin skin test (TST) and decreasing in lymphoproliferative responses compared to HTLV-1 uninfected persons, these studies were not performed in individuals with history of tuberculosis or evidence of M. tuberculosis infection. Therefore the reasons why HTLV-1 infection increases susceptibility to infection and severity of tuberculosis are not understood.The aim of this study was to evaluate how HTLV-1 may influence the clinical, bacteriologic and immunologic presentation of tuberculosis.
Methods The study prospectively enrolled and followed 13 new cases of tuberculosis associated with HTLV-1 (cases) and 25 patients with tuberculosis without HTLV-1 infection (controls). Clinical findings, bacterial load in the sputum, x-rays, immunological response and death were compared in the two groups. Results There were no differences in the demographic, clinical and TST response between the two study groups. IFN-γ and TNF-α production was higher in unstimulated cultures of mononuclear cells of case than in control patients (p < 0.01). While there was no difference in IFN-γ production in PPD stimulated cultures, TNF-α levels were lower in cases than in controls (p = 0.01). There was no difference in the bacterial load among the groups but sputum smear microscopy results became negative faster in cases than in controls. Death only occurred in two co-infected patients. Conclusion
While the increased susceptibility for tuberculosis infection in HTLV-1 infected subjects may be related to impairment in TNF-α production, the severity of tuberculosis in co-infected patients may be due to the enhancement of the Th1 inflammatory response, rather than in their decreased ability to control bacterial growth. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.1186/1471-2334-12-199 | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | Tuberculosis | pt_BR |
dc.subject | Mycobacterium tuberculosis | pt_BR |
dc.title | Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis | pt_BR |
dc.title.alternative | BMC Infectious Diseases | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 12 | pt_BR |
dc.publisher.country | Brasil | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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